Gliadin

Simple protein, one of the prolamines, derived from the gluten of wheat, rye, etc. May be separated into 4 discrete electrophoretic fractions. It is the toxic factor associated with CELIAC DISEASE.

Also Known As:

Networked: 1291 relevant articles (47 outcomes, 136 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Troncone, Riccardo: 26 articles (02/2022 - 03/2003)
2.	Auricchio, Salvatore: 24 articles (02/2022 - 03/2003)
3.	Fasano, Alessio: 19 articles (12/2021 - 01/2006)
4.	Morita, Eishin: 18 articles (04/2021 - 03/2004)
5.	Gianfrani, Carmen: 16 articles (12/2021 - 03/2003)
6.	Matsuo, Hiroaki: 16 articles (04/2021 - 03/2004)
7.	Barone, Maria Vittoria: 15 articles (05/2022 - 06/2004)
8.	Mazzarella, Giuseppe: 14 articles (07/2021 - 03/2003)
9.	Auricchio, Renata: 13 articles (02/2022 - 03/2003)
10.	Murray, Joseph A: 12 articles (01/2019 - 04/2008)

Related Diseases

1.	Celiac Disease (Celiac Sprue) 01/01/2020 - "In summary, this study provides a new, more accurate and sensitive, as well as less expensive system to detect anti-gliadin for the improved diagnosis of celiac disease." 04/01/2008 - "Deamidated gliadin antibody is a better diagnostic test for celiac disease than the conventional gliadin antibody testing; although histopathology remains the gold standard test for diagnosis of celiac patients." 11/11/1990 - "According to these results the authors conclude that the efficacy of this test is less sensitive in the newly diagnosed celiac patients, which means that it is not suitable for screening purpose, but useful for detecting gliadin sensitivity during the diagnostic period of celiac disease (e. " 01/01/2022 - "Moreover, these CD8+ T cells efficiently eliminated pathogenic gliadin-specific CD4+ T cells from the leukocytes of celiac disease patients in vitro. " 01/01/2020 - "Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. "
2.	Atrophy 08/01/1994 - "The disease is traditionally characterized by villous atrophy responsive to gliadin. " 02/01/1993 - "We have retrospectively assessed the value of the anti-gliadin antibody test in detecting villous atrophy of the small bowel. " 02/01/1993 - "It is suggested that TcR alpha beta+ but not TcR gamma delta+ IEL are sensitised to gliadin in coeliac disease, and that only the former cells play a direct part in the pathogenesis of the villous atrophy. " 01/01/1986 - "Strong staining in the main gliadin area (bands from 31 to 38 kd) indicated severely damaged intestinal mucosa whereas the serum of DH patients with partial villous atrophy or normal mucosa showed usually weaker staining. " 10/01/1985 - "Increased gliadin antibody levels were found more frequently in patients with subtotal villous atrophy (9 out of 17 patients, or 53%; p less than 0.05) than in patients with partial villous atrophy (2 out of 13 patients, or 15%) or normal villous appearance (2 out of 10 patients, or 20%). "
3.	Diarrhea 10/30/2017 - "The number of subjects with positivity to apple, orange, gluten, and gliadin in the diarrhea subgroup, and egg white, pineapple, soybean, lettuce, and leek in the non-diarrhea subgroup was significantly higher compared with controls. " 04/01/1998 - "A 28-year-old man presented with selective immunoglobulin A deficiency and severe diarrhea responding to a gliadin-free diet. " 10/01/2004 - "Wheat gliadin is known mainly as the causative substance for enteropathy accompanied by diarrhea (celiac disease) and food-dependent exercise-induced anaphylaxis. " 04/19/2010 - "Six rhesus macaques were selected for study from a pool of 500, including two healthy controls and four gluten-sensitive animals with elevated anti-gliadin or anti-TG2 antibodies as well as history of non-infectious chronic diarrhea. " 10/30/2017 - "IgG4 titers to wheat, gluten and gliadin in the diarrhea subgroup, and lettuce, leek and taro in the non-diarrhea subgroup tended to be higher compared with controls. "
4.	Cerebellar Ataxia (Dysmetria) 02/04/2011 - "Selective loss of Purkinje cells in a patient with anti-gliadin-antibody-positive autoimmune cerebellar ataxia." 01/01/2016 - "As regards the association of HIV infection and autoimmune cerebellar ataxia, a previous report suggested that anti-gliadin antibody was detected in about 30% of HIV-infected children, though there is no reference to an association with cerebellar ataxia. " 01/01/2009 - "[A case of anti-gliadin-antibody-positive cerebellar ataxia effectively treated with intravenous immunoglobulin in which voxel-based morphometry and FineSRT were diagnostically useful]." 04/01/2013 - "Anti-Yo, -Zic, -CARPVIII, -Tr, -Ri, -Hu, -Ma, -CRMP-5, -ANNA-3, -PCA-2, -VGCC, and -mGluR antibodies (Abs) are found in paraneoplastic cerebellar ataxia, whereas anti-GAD, -thyroid, and -gliadin Abs are found in non-paraneoplastic cerebellar ataxia. " 01/01/2016 - "Seven of the 12 anti-gliadin antibody-positive patients, three of the four anti-GAD antibody-positive patients, and three of the six anti-thyroid antibody-positive patients responded well to immunotherapy, indicating that 59% of patients with ataxia-associated antibody-positive cerebellar ataxia undergoing immunotherapy responded well. "
5.	Multiple System Atrophy 01/01/2009 - "Treatment was effective in four cerebellar cortical atrophy patients (two anti-GAD antibody-positive and two anti-gliadin antibody-positive) and in one anti-thyroid antibody-positive spinocerebellar ataxia type 3 (SCA3) patient, but not in two multiple system atrophy (MSA) patients. " 10/01/2014 - "We measured anti-deamidated gliadin peptide (DGP) antibody levels in 49 patients with cerebellar ataxia, excluding those with multiple system atrophy, hereditary spinocerebellar ataxia, or cancer, as well as those who were receiving oral administration of phenytoin. " 01/01/2016 - "We measured the level of autoantibodies (including anti-gliadin antibody, anti-glutamic acid decarboxylase (GAD) antibody, and anti-thyroid antibody) in 58 Japanese patients with cerebellar ataxia, excluding those with multiple system atrophy, hereditary spinocerebellar ataxia, cancer, or those who were receiving phenytoin, and the efficacy of immunotherapy was assessed. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Antibodies
3.	Glutens (Glutelin)
4.	Immunoglobulin A (IgA)
5.	Immunoglobulin G (IgG)
6.	Protein Glutamine gamma Glutamyltransferase 2
7.	Transglutaminases
8.	Epitopes
9.	Proteins (Proteins, Gene)
10.	Enzymes

Related Therapies and Procedures

1.	Gluten-Free Diet
2.	Immunotherapy
3.	Enema (Enemas)
4.	Phototherapy (Light Therapy)
5.	Complementary Therapies (Alternative Medicine)