Papillary Thyroid Cancer

An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.

Also Known As:

Thyroid Cancer, Papillary; Familial Nonmedullary Thyroid Cancer; Nonmedullary Thyroid Carcinoma; Papillary Carcinoma Of Thyroid; Papillary Thyroid Carcinoma; Thyroid Carcinoma, Papillary; Cancer, Papillary Thyroid; Cancers, Papillary Thyroid; Carcinoma, Nonmedullary Thyroid; Carcinoma, Papillary Thyroid; Carcinomas, Nonmedullary Thyroid; Carcinomas, Papillary Thyroid; Nonmedullary Thyroid Carcinomas; Papillary Thyroid Cancers; Papillary Thyroid Carcinomas; Thyroid Cancers, Papillary; Thyroid Carcinoma, Nonmedullary; Thyroid Carcinomas, Nonmedullary; Thyroid Carcinomas, Papillary

Networked: 6133 relevant articles (142 outcomes, 879 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Thyroid Neoplasms (Thyroid Cancer)
4.	Lymphatic Metastasis
5.	Thyroid Nodule (Nodule, Thyroid)

Experts

1.	Miyauchi, Akira: 60 articles (04/2024 - 01/2003)
2.	Zhang, Hao: 46 articles (04/2024 - 09/2012)
3.	Wang, Yu: 35 articles (04/2024 - 01/2013)
4.	Basolo, Fulvio: 33 articles (12/2023 - 02/2003)
5.	Dong, Wenwu: 33 articles (06/2023 - 09/2012)
6.	Ito, Yasuhiro: 32 articles (03/2022 - 04/2005)
7.	Wang, Zhihong: 30 articles (04/2024 - 01/2013)
8.	Zhu, Jingqiang: 30 articles (01/2024 - 04/2014)
9.	Tae, Kyung: 29 articles (01/2024 - 08/2011)
10.	Sun, Wei: 29 articles (06/2023 - 07/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Papillary Thyroid Cancer:

1.	IodineIBA 01/01/2024 - "Radioactive iodine administration is not associated with improved disease-specific survival in classic papillary thyroid carcinoma greater than 4 cm confined to the thyroid." 01/01/2020 - "A Phase II Multi-Center, Non-Randomized, Parallel Group, Non-Inferiority Study to Compare the Efficacy of No Radioactive Iodine Remnant Ablation to Remnant Ablation Treatment in Low- to Intermediate-Risk of Papillary Thyroid Cancer: The MOREthyroid Trial Protocol." 01/01/2023 - "Radioactive iodine is the first-line treatment for patients with metastatic Papillary Thyroid Cancer (PTC). " 06/01/2015 - "To assess the efficacy of radioactive iodine (RAI) for the treatment of residual papillary thyroid cancer (PTC) after surgery. " 10/01/2023 - "The study was to evaluate the effect of radioactive iodine (RAI) treatment application time and clinical, histopathological factors on ablation success in patients with operated papillary thyroid cancer (PTC) in low and intermediate-risk. "
2.	Thyroglobulin FDA Link 08/01/2007 - "A followup strategy emphasizing routine cervical ultrasonography and unstimulated thyroglobulin is effective in identifying patients with recurrent papillary thyroid cancer, and may minimize the indiscriminate use of therapeutic radioiodine for radiographically occult disease. " 03/01/2011 - "Immunohistochemical staining with TTF-1 and thyroglobulin is very useful in confirming the diagnosis of papillary thyroid carcinoma especially in metastatic sites. " 07/01/2011 - "This study was to evaluate the efficacy of the first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated thyroglobulin for evaluating efficacy of reoperation. " 01/01/2020 - "Needle biopsy of the mass in the right upper neck revealed positive results for thyroglobulin and TTF-1 on immunostaining, and a papillary thyroid carcinoma was observed with papillary and follicular patterns. " 11/01/2016 - "Papillary thyroid carcinomas with biochemical incomplete or indeterminate responses to initial treatment: repeat stimulated thyroglobulin assay to identify disease-free patients."
3.	Biomarkers (Surrogate Marker)IBA 06/14/2022 - "The purpose of this study was to identify promising biomarkers for improved diagnosis and prognosis of papillary thyroid cancer (PTC). " 12/01/2013 - "This study was designed to evaluate whether the periablative change in serum markers can predict biochemical remission in papillary thyroid cancer (PTC) patients. " 02/23/2018 - "Thyroid ultrasound and ultrasound-guided fine-needle aspiration (USG/FNA) biopsy are currently used for diagnosing papillary thyroid carcinoma (PTC), but their detection limit could be improved by combining other biomarkers. " 12/01/2013 - "Limited clinical value of periablative changes of serum markers in the prediction of biochemical remission in patients with papillary thyroid cancer." 04/27/2024 - "This study identifies biomarkers linked to SUMOylation in papillary thyroid carcinoma (PTC), aiming to advance therapeutic and prognostic strategies. "
4.	Ethanol (Ethyl Alcohol)IBA 04/01/2008 - "The purpose of this study was to retrospectively evaluate the efficacy of ultrasonography-guided percutaneous ethanol injection (PEI) for neck recurrence of papillary thyroid carcinoma (NR-PTC). " 01/01/2022 - "Long-Term Efficacy of Ethanol Ablation as Treatment of Metastatic Lymph Nodes From Papillary Thyroid Carcinoma." 09/01/2011 - "Efficacy of ultrasound-guided percutaneous ethanol injection treatment in patients with a limited number of metastatic cervical lymph nodes from papillary thyroid carcinoma." 04/01/2024 - "Percutaneous ethanol ablation may be a safe primary treatment modality for papillary thyroid carcinoma lateral neck nodal recurrence in selected patients with low-volume nodal disease." 04/01/2024 - "We conducted a retrospective study of patients with lateral neck papillary thyroid carcinoma treated with percutaneous ethanol ablation from 2013 to 2018. "
5.	Proteins (Proteins, Gene)FDA Link 01/01/2021 - "In this study, GPER1 gene and protein expression are described in non-malignant and in papillary thyroid cancer (PTC), as well as its association with clinical features of patients with PTC. " 01/01/2021 - "In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. " 06/01/2016 - "The purpose of this study was to evaluate the association between expression of cancer-associated fibroblast (CAF)-related proteins in papillary thyroid carcinoma (PTC) and clinicopathologic factors. " 01/01/2016 - "Thus, in the present study, the protein expression levels of FAM172A in human papillary thyroid carcinoma were investigated, and the effect of the FAM172A protein on the proliferation of IHH‑4 human papillary thyroid carcinoma cells, and its potential molecular underlying mechanisms were examined. " 09/01/2015 - "The BRAF (V600E) mutation is the most prevalent type of genetic alteration that has been identified in papillary thyroid carcinoma (PTC); in addition, previous immunohistochemical studies have revealed the overexpression of p53 protein in PTC. "
6.	Galectin 3 (LGALS3)IBA 02/01/2016 - "As reported in several studies, galectin-3 is associated with prognostic factor in papillary thyroid carcinoma, but its expression and prognostic role has not been evaluated in papillary microcarcinoma (PTMC). " 07/01/2006 - "Our study confirms the high diagnostic value of galectin-3 in papillary thyroid carcinoma and reveals the similar efficiency of CA50. " 08/01/2005 - "As reported in several studies, galectin-3 is highly expressed in papillary thyroid carcinoma, but its expression has not been investigated in papillary microcarcinoma, which is a variant of papillary thyroid carcinoma. " 04/01/2003 - "Our study suggests that the variable pattern of galectin-3 expression may reflect a difference in biologic behavior between HTT and papillary thyroid carcinoma." 04/01/2022 - "Diagnostic utility of CK19 and galectin-3 in differentiating papillary thyroid carcinoma from nonneoplastic lesions of thyroid."
7.	AntibodiesIBA 10/01/2017 - "The objective of this study is to comprehensively analyze the association between thyroid autoimmune antibodies and disease statuses of papillary thyroid carcinoma (PTC). " 11/01/2014 - "The goal of the present study was to investigate whether p53 antibodies (Abs) could be a relevant marker for papillary thyroid carcinoma (PTC). " 09/01/2023 - "An Autobiographical Case Report on Papillary Thyroid Carcinoma with Positive Antithyroid Antibodies: Coincidence or Correlated?" 11/05/2022 - "Papillary thyroid carcinoma was diagnosed in six patients and one of these patients was positive for thyroid antibodies. " 10/01/2017 - "Thyroid autoimmune antibodies in patients with papillary thyroid carcinoma: a double-edged sword?"
8.	Cyclin D1IBA 01/01/2007 - "This study addressed the immunohistochemical expression of MUC1 in papillary thyroid carcinoma (PTC) of different histotypes, sizes, and morphological features of aggressiveness, and its correlation with the overexpression of cyclin D1, a target molecule of the Wnt pathway. " 11/11/2023 - "Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma." 01/01/2023 - "Cyclin D1 is highly expressed in papillary thyroid carcinoma (PTC). " 01/01/2023 - "Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma." 01/01/2022 - "Mitochondrial Respiration Inhibition Suppresses Papillary Thyroid Carcinoma Via PI3K/Akt/FoxO1/Cyclin D1 Pathway."
9.	Iodine-131IBA 01/01/2020 - "These findings suggest that this BRAF mutation may be a predictor of the efficacy of iodine-131 treatment for papillary thyroid cancer." 08/01/2019 - "The aim of the present study was to predict the prognostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the metastatic lymph nodes (mLNs) of patients with papillary thyroid carcinoma (PTC) with a negative iodine-131 (131I) whole-body scan (WBS). " 12/31/2023 - "260 patients with papillary thyroid cancer (PTC) were retrospectively analyzed, including 166 patients treated with radioactive iodine-131 (131I) classified into the 131I group and 94 patients without 131I treatment classified into the control group. " 01/01/2020 - "Patient Findings: A 73-year-old man presenting with locally advanced papillary thyroid carcinoma containing a minor component of ATC was treated with surgery and iodine-131. " 01/01/2020 - "Objective: To investigate the correlation between the BRAF V600E gene mutation and clinicopathological features and thyroid function after iodine-131 treatment in patients with papillary thyroid cancer (PTC). "
10.	Thyrotropin Alfa FDA LinkGeneric 01/01/2009 - "In this study, we used an alternative protocol for TRA with the use of one kit of rhTSH in twenty patients diagnosed with low risk papillary thyroid carcinoma. " 01/01/2003 - "The authors describe a patient with papillary thyroid cancer in whom a 2-day rhTSH protocol was used for diagnosis and extended for therapeutic purposes. " 12/01/2019 - " retrospectively enrolled 177 patients with papillary thyroid cancer (mean age = 44 years; 50 males, 127 females) who received rhTSH before radioiodine therapy (RIT). " 09/01/2003 - "After primary treatments for papillary thyroid carcinoma, rhTSH testing under L-T4 therapy and neck US may be regarded as first-line evaluations. " 12/01/2004 - "The fold increase in the serum Tg after rhTSH treatment was highest in papillary thyroid carcinoma and lowest in Hurthle cell carcinoma. "

Therapies and Procedures

1.	Thyroidectomy 01/01/2024 - "Compared with lobectomy, total thyroidectomy was beneficial in reducing recurrence and disease-free survival and may be considered a more optimal approach for unilateral multifocal papillary thyroid carcinoma." 01/01/2021 - "Ambulatory thyroidectomy is safe and beneficial in papillary thyroid carcinoma: Randomized controlled trial." 01/01/2022 - "Overall survival is improved with total thyroidectomy and radiation for male patients and patients older than 55 with T2N0M0 Stage 1 classic papillary thyroid cancer." 06/01/2012 - "Although video-assisted (VA) thyroidectomy emerged as effective treatment for selected patients with papillary thyroid carcinoma (PTC), some concerns remain about obtaining adequate central neck node clearance. " 10/01/2020 - "Transoral robotic thyroidectomy is a safe and effective procedure and may be a feasible option for patients with papillary thyroid carcinomas larger than 1 cm."
2.	Therapeutics 05/01/2024 - "The main objective of our work was to identify the clinical and molecular markers that may help to predict RAI avidity and RAI therapy response of metastatic lesions in a cohort of papillary thyroid cancer (PTC) patients. " 08/01/2017 - "Ultrasound guided percutaneous RFA for cervical metastatic LNs from papillary thyroid carcinoma is a feasible, effective and safe therapy. " 10/01/2023 - "The aim of the present study was to investigate the factors influencing the short-term response to the initial radioiodine therapy (RT) course in patients with intermediate- and high-risk papillary thyroid carcinoma (PTC). " 03/01/2023 - "The role of BRAF V600E mutation in post-surgical 131I therapy in papillary thyroid carcinoma: a study based on SPECT-CT uptake analysis." 01/01/2022 - "Reminiscence therapy care program as a potential nursing intervention to relieve anxiety, depression, and quality of life in older papillary thyroid carcinoma patients: A randomized, controlled study."
3.	Neck Dissection (Radical Neck Dissection) 09/01/2020 - "Some studies have shown that prophylactic lateral neck dissection (pLND) may be beneficial for patients with papillary thyroid carcinoma (PTC); however, none of the Western guidelines currently recommends this procedure. " 06/01/2020 - "In small solitary papillary thyroid carcinomas (T1 and T2), prophylactic central neck dissection is not indicated as it does not bring benefits in terms of improved patient survival and at the same time significantly increases the risk of temporary and permanent postoperative complications. " 01/01/2002 - "Is a bilateral modified radical neck dissection beneficial for patients with papillary thyroid cancer?" 01/01/2023 - "Particularly in patients with papillary thyroid cancer, intraoperative FS can be effective in detecting extrathyroidal extension and can assist the surgeon in determining the extent of thyroid surgery and central neck dissection. " 03/01/2020 - "To evaluate the efficacy of prophylactic central neck dissection (pCND) in hemithyroidectomy for clinically node-negative papillary thyroid carcinoma (PTC). "
4.	Radiofrequency Ablation 01/01/2022 - "Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status." 01/01/2021 - "Ultrasonography-guided radiofrequency ablation (RFA) has been used to treat low-risk small papillary thyroid carcinoma (PTC) and yielded promising results. " 09/01/2019 - "The purpose of this study was to evaluate the longer-term efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) for treating locally recurrent papillary thyroid cancer (PTC). " 01/01/2021 - "To evaluate the safety and efficacy of radiofrequency ablation (RFA) for metastatic lymph nodes (LNs) in children and adolescents with papillary Thyroid Carcinoma (PTC). " 01/01/2023 - "Clinical outcomes of ultrasound-guided radiofrequency ablation for solitary T1N0M0 papillary thyroid carcinoma: A retrospective study with more than 5 years of follow-up."
5.	Lymph Node Excision (Lymph Node Dissection) 01/01/2022 - "The efficacy of prophylactic central compartment lymph node dissection for papillary thyroid carcinoma remains controversial. " 01/01/2024 - "Impact of prophylactic central lymph node dissection on the complications and recurrence rates in papillary thyroid carcinoma-An AFCE (French-speaking Association of Endocrine Surgery) multicentre study based on the EUROCRINE® national data." 04/01/2023 - "Evaluation of the role of prophylactic bilateral central neck lymph node dissection in patients with papillary thyroid carcinoma: a case controlled study." 06/01/2022 - "Long-Term Survival in Patients With Papillary Thyroid Cancer Who Did Not Undergo Prophylactic Central Lymph Node Dissection: A SEER-Based Study." 01/01/2021 - "Surgical Extent of Central Lymph Node Dissection for Papillary Thyroid Carcinoma Located in the Isthmus: A Propensity Scoring Matched Study."