Abstract | BACKGROUND: METHODS: In this parallel-group randomized controlled trial, we assessed 101 patients aged 20 to 70 years with small/noninvasive papillary thyroid carcinoma and no clinical metastases or history of cervical surgery/radiation exposure. Randomization ran from April 2015 to November 2017. Data were collected between April 2015 and October 2020. Of the 101 enrolled patients, 50 underwent total thyroidectomy (TTx group) and 51 underwent total thyroidectomy as well as prophylactic central compartment lymph node dissection (TTx+pCND group). Surgical completeness, local recurrence, successful ablation, postoperative complication, and papillary thyroid carcinoma upstaging were compared between the 2 groups. RESULTS: No patient showed structural recurrence after 46.6 ± 9.1 months of follow-up. Both groups had similar rates of surgical completeness and successful ablation. There was no difference in the incidence of complications. More patients were upstaged to pN1a in the TTx+pCND group compared to those in the TTx group (P < .05). CONCLUSIONS:
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Authors | Jong-Hyuk Ahn, Jung Hak Kwak, Sang Gab Yoon, Jin Wook Yi, Hyeong Won Yu, Hyungju Kwon, Su-Jin Kim, Kyu Eun Lee |
Journal | Surgery
(Surgery)
Vol. 171
Issue 1
Pg. 182-189
(01 2022)
ISSN: 1532-7361 [Electronic] United States |
PMID | 34391573
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2021. Published by Elsevier Inc. |
Topics |
- Adult
- Aged
- Female
- Humans
- Incidence
- Lymph Node Excision
(adverse effects, statistics & numerical data)
- Lymph Nodes
(pathology, surgery)
- Lymphatic Metastasis
(prevention & control)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(epidemiology, prevention & control)
- Postoperative Complications
(epidemiology, etiology)
- Prophylactic Surgical Procedures
(adverse effects, statistics & numerical data)
- Prospective Studies
- Thyroid Cancer, Papillary
(mortality, pathology, surgery)
- Thyroid Neoplasms
(mortality, pathology, surgery)
- Young Adult
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