Thyrotropin Alfa

A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.

Also Known As:

Networked: 32 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rehm, Patrice K: 2 articles (06/2015 - 06/2014)
2.	Park, Anna: 2 articles (03/2013 - 03/2013)
3.	Bird, Julie J: 2 articles (03/2013 - 03/2013)
4.	Greene, Ben: 2 articles (03/2013 - 03/2013)
5.	Zarazinski, Christine: 2 articles (03/2013 - 03/2013)
6.	Qiu, Huawei: 2 articles (03/2013 - 03/2013)
7.	Pan, Clark Q: 2 articles (03/2013 - 03/2013)
8.	Kingsbury, Jonathan S: 2 articles (03/2013 - 03/2013)
9.	McPherson, John M: 2 articles (03/2013 - 03/2013)
10.	Honey, Denise M: 2 articles (03/2013 - 03/2013)

Related Diseases

1.	Thyroid Neoplasms (Thyroid Cancer) 11/01/2010 - "This study sought to assess the safety, efficacy, impact on hypothyroid symptoms, and pharmacokinetics of SKG-02 (rhTSH, thyrotropin alfa) in the diagnostic follow-up of Japanese patients with well-differentiated thyroid carcinoma (WDTC). " 05/03/2012 - "Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer." 08/01/2010 - "The use of thyrogen in the treatment of differentiated thyroid carcinoma: an intraindividual comparison of clinical effects and implications of daily life." 01/01/2010 - "We believe that the use of Thyrogen for radioiodine treatment of metastatic thyroid cancer may also provide a better option due to its rapid preparation time and safety. " 01/01/2010 - "Thyrogen-assisted diagnosis and radioiodine ablation of thyroid remnant provide a reliable tool in the management of thyroid cancer without sacrificing patient quality of life. "
2.	Neoplasms (Cancer) 09/01/2000 - "These guidelines advocate TSH-stimulated serum Tg measurements, done either during thyroid hormone withdrawal or stimulation with recombinant human TSH (rhTSH, Thyrogen), that often identify the presence of cancer well before diagnostic whole-body scanning or other imaging studies can spot the tumor, which offers the opportunity to treat recurrent disease at an early stage. " 03/01/2014 - "Few data exist on using thyrotropin alfa (recombinant human thyroid-stimulating hormone [rhTSH]) with radioiodine for thyroid remnant ablation of patients who have T4 primary tumors (invasion beyond the thyroid capsule). " 01/01/2000 - "Because iodine uptake by most thyroid carcinomas is quite low in the absence of high levels of ambient TSH, we used recombinant human TSH (rhTSH) (Thyrogen) to achieve a concentration of 131I activity in the tumor high enough for a significant cytotoxic effect. "
3.	Hypothyroidism 07/01/2003 - "The introduction of human recombinant thyrotropin (rhTSH/Thyrogen) into the diagnosis of thyroid cancer has substantially ameliorated the patient's quality of life through the avoidance of debilitating hypothyroidism. " 01/01/2001 - "This study tested the hypothesis that administration of human recombinant thyroid-stimulating hormone (rhTSH: Thyrogen, thyrotropin alpha) could promote iodine-131 ((131)I) uptake in the therapy for metastatic or locally invasive differentiated thyroid cancer (DTC), obviating L-thyroxine suppressive therapy (L-T4) withdrawal and hypothyroidism in patients with advanced disease. " 01/01/2009 - "Recombinant human TSH (rhTSH, thyrotropin alfa [Thyrogen(®)], Genzyme Corporation, Cambridge, MA, USA) was developed to provide TSH stimulation without withdrawal of thyroid hormone and clinical hypothyroidism. "
4.	Neoplasm Metastasis (Metastasis) 07/01/2003 - "Owo patients had a positive Tg and positive WBS with skull, lung and hepatic metastases and received 150 131I after preparation with Thyrogen. " 04/01/2011 - "Recombinant human TSH (rhTSH, Thyrogen(®)) has been used in the follow-up of patients with thyroid cancer to increase the sensitivity for detection of recurrence or metastasis. " 11/01/2003 - "The appearance of a focus of uptake near the lacrimal sac on Thyrogen scanning in a patient with a history of thyroid carcinoma may not be due to a new focus of metastasis and may indeed be due to pooling of 131I in the lacrimal sac due to nasolacrimal duct blockage." 11/01/2003 - "A recent recombinant human thyroid-stimulating hormone (Thyrogen) scan had shown a focus of uptake adjacent to the right eye that was initially thought to be a possible metastasis. " 07/01/2003 - "Furthermore, it appears that Thyrogen could be used in the treatment of metastases as an alternative to thyroid hormone withdrawal."
5.	Thyroid Diseases (Thyroid Disease) 12/01/2004 - "Current and future clinical uses of recombinant human thyroid-stimulating hormone (rhTSH; Thyrogen, Genzyme) in thyroid diseases are discussed in the review published in this issue of Expert Opinion on Pharmacotherapy [2]. "

Related Drugs and Biologics

1.	Thyrotropin (Thyroid-Stimulating Hormone)
2.	Hormones
3.	Thyrotropin Alfa
4.	Thyroxine (Levothyroxine)
5.	Thyroglobulin
6.	Iodine
7.	Carbon Monoxide

Related Therapies and Procedures

1.	Thyroidectomy
2.	Drug Therapy (Chemotherapy)