NADPH Oxidase 2

An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.

Also Known As:

Networked: 200 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carnevale, Roberto: 4 articles (01/2022 - 11/2011)
2.	Kowluru, Renu A: 4 articles (05/2021 - 05/2015)
3.	Li, Jing: 4 articles (01/2018 - 10/2015)
4.	Chatterjee, Shampa: 3 articles (10/2021 - 02/2014)
5.	Feinstein, Sheldon I: 3 articles (10/2021 - 02/2014)
6.	Fisher, Aron B: 3 articles (10/2021 - 02/2014)
7.	Li, Hui: 3 articles (01/2021 - 10/2012)
8.	Shah, Ajay M: 3 articles (02/2020 - 07/2015)
9.	Violi, Francesco: 3 articles (01/2019 - 11/2011)
10.	Brann, Darrell W: 3 articles (01/2018 - 01/2017)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice." 11/01/2023 - "The leukocyte NADPH oxidase 2 (NOX2) regulates inflammation independent of its antimicrobial activity. " 11/15/2022 - "Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice." 01/01/2021 - "Beyond the Extra Respiration of Phagocytosis: NADPH Oxidase 2 in Adaptive Immunity and Inflammation." 01/01/2019 - "NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow."
2.	Ischemia 01/01/2015 - "Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. " 05/01/2012 - "NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells." 01/15/2016 - "During ischemia/reperfusion (IR), increased activation of angiotensin AT1 receptors recruits NADPH oxidase 2 (NOX2) which contributes to oxidative stress. " 01/01/2016 - "Ischemia-reperfusion (IR) injury after lung transplantation, which affects both short- and long-term allograft survival, involves activation of NADPH oxidase 2 (NOX2) and activation of invariant natural killer T (iNKT) cells to produce IL-17. " 11/01/2023 - "Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia."
3.	Neuroinflammatory Diseases 01/01/2021 - "Activation of microglial NADPH oxidase 2 (NOX2) leads to oxidative stress and neuroinflammation, which may contribute to hypoxic damage in the developing brain. " 07/14/2022 - "We tested the hypothesis that ROS activity mediated by NADPH oxidase 2 (NOX2) contributes to acute brain injury but promotes functional recovery during the delayed phase, which is linked with neuroinflammation, autophagy, angiogenesis, and the PI3K/Akt signaling pathway. " 11/01/2023 - "Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia." 01/01/2021 - "The aim of this study was to explore the anti-inflammatory effects and neurological function improvement of LPA1 inhibition after intracerebral haemorrhage (ICH) in mice and to determine whether prostaglandin E2 (PGE2), E-type prostaglandin receptor 2 (EP2), and NADPH oxidase 2 (NOX2) signalling are involved in LPA1-mediated neuroinflammation. "
4.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2023 - "Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury." 01/01/2022 - "Inhibition of NADPH oxidase 2 (NOX2) reverses cognitive deficits by modulating excitability and excitatory transmission in the hippocampus after traumatic brain injury." 05/01/2020 - "An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury." 01/01/2018 - "NADPH oxidase 2 deletion enhances neurogenesis following traumatic brain injury." 12/01/2017 - "Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury."
5.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/2019 - "Ablation of ROS derived from phagocytic NADPH oxidase 2 is protective against autoimmune diabetes in non-obese diabetic (NOD) mice. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Antioxidants
4.	Caspase 3 (Caspase-3)
5.	Creatinine
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Nitrogen
8.	Myosin Light Chains (Myosin Essential Light Chain)
9.	Interleukin-10 (Interleukin 10)
10.	Urea (Carbamide)

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Lung Transplantation
4.	Ovariectomy (Oophorectomy)
5.	Drug Therapy (Chemotherapy)