Inositol Polyphosphate 5-Phosphatases

Phosphoinositide phosphatases that catalyze the removal of the 5' phosphate from INOSITOL 1,4,5-TRISPHOSPHATE or myo-inositol 1,3,4,5-tetrakisphosphate, resulting in inositol 1,4-bisphosphate and phosphate. They have important functions in the metabolism of INOSITOL PHOSPHATES and inositol 1,4,5-trisphosphate signaling pathways such as CALCIUM SIGNALING.

Also Known As:

1,4,5-Triphosphate-1,2,4,5-Tetrakisphosphate 5-Phosphatase; Inositol 5-Phosphatase; Inositol Polyphosphate 5-Phosphatase; Inositol Triphosphate 5-Phosphatase; Inositol-1,4,5-Trisphosphate 5'-Phosphatase; Inositol-1,4,5-Trisphosphate 5-Phosphatase; Inositol-Polyphosphate 5-Phosphatase; Ins(1,4,5)P3 5'-Phosphatase; Inositol 5 Phosphatase; Inositol Polyphosphate 5 Phosphatase; Inositol Polyphosphate 5 Phosphatases; Inositol Triphosphate 5 Phosphatase

Networked: 93 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Phosphoinositide Phosphatases: 50
        Inositol Polyphosphate 5-Phosphatases: 93
        human INPP5A protein
        human INPP5F protein
        mouse Inpp5a protein
        mouse Inpp5f protein
        zebrafish inpp5ka protein
        zebrafish inpp5kb protein

Experts

1.	Lowe, Martin: 10 articles (11/2021 - 08/2006)
2.	De Camilli, Pietro: 8 articles (01/2019 - 09/2007)
3.	Mitchell, Christina A: 7 articles (02/2016 - 01/2007)
4.	Ye, Yan: 5 articles (03/2020 - 01/2013)
5.	Jücker, Manfred: 4 articles (01/2022 - 11/2012)
6.	Luo, Na: 4 articles (10/2017 - 12/2012)
7.	Sun, Yang: 4 articles (10/2017 - 12/2012)
8.	Zhang, Lin Jie: 4 articles (01/2017 - 01/2013)
9.	Xu, Jiegou: 3 articles (03/2020 - 03/2016)
10.	Pirruccello, Michelle: 3 articles (01/2019 - 02/2010)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) gene is associated with arthrosclerosis, gastric cancer and diabetes. " 03/13/2020 - "Previous studies have shown reduced expression of Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) and its tumor-suppressive role in gastric cancer (GC). " 01/22/2017 - "Past studies have shown that the Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is commonly downregulated in gastric cancer, which contributes to elevated activation of PI3K/Akt signaling, proliferation and tumorigenesis of gastric cancer cells. "
2.	Oculocerebrorenal Syndrome (Lowe Syndrome) 11/02/2021 - "We show here that SdhA binds and blocks the action of OCRL (OculoCerebroRenal syndrome of Lowe), an inositol 5-phosphatase pivotal for controlling endosomal dynamics. " 01/01/2021 - "OCRL gene, which encodes an inositol polyphosphate 5-phosphatase, is associated with Lowe syndrome when mutated. " 01/01/2020 - "Lowe syndrome and Dent-2 disease are caused by mutations in the OCRL gene, which encodes for an inositol 5-phosphatase. " 01/01/2020 - "Complete oculocerebrorenal phenotype of Lowe syndrome in a female patient with half reduction of inositol polyphosphate 5-phosphatase." 10/15/2017 - "Mutations in OCRL, an inositol polyphosphate 5-phosphatase that dephosphorylates PI(4,5)P2, cause Lowe syndrome. "
3.	Neoplasms (Cancer) 01/01/2023 - "The PI3K/AKT/mTOR pathway is frequently upregulated in cancer cells and the SH2-containing inositol 5-phosphatase SHIP1 can act as a negative regulator of the PI3K/AKT pathway. " 01/01/2022 - "Here, the functional role of the tumor suppressor SHIP1 (SH2 domain containing inositol-5 phosphatase 1) in the pathogenesis of MPNs was investigated. " 11/01/2019 - "The AKT pathway is a frequently upregulated pathway in most cancer cells and the SH2-containing inositol 5-phosphatase SHIP1 is a negative regulator of the AKT pathway. " 09/01/2018 - "The inositol 5-phosphatase SHIP1 acts as negative regulator of intracellular signaling in myeloid cells and is a tumor suppressor in myeloid leukemogenesis. " 03/01/2016 - "The Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is implicated in diabetes, arthrosclerosis, and cancer. "
4.	Melanoma (Melanoma, Malignant) 01/01/2013 - "Here we report that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase, has a tumour suppressive role in melanoma. " 08/01/2013 - "Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. " 02/01/2016 - "The roles that 5-phosphatases play in suppressing cell proliferation and transformation are slow to emerge; however, the 5-phosphatase PIPP [proline-rich inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase (INPP5J)] has recently been identified as a putative tumour suppressor in melanoma and breast cancer and SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase 1] inhibits haematopoietic cell proliferation. "
5.	Carcinogenesis 01/22/2017 - "Past studies have shown that the Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is commonly downregulated in gastric cancer, which contributes to elevated activation of PI3K/Akt signaling, proliferation and tumorigenesis of gastric cancer cells. " 01/07/2022 - "Increasing evidence has suggested inositol polyphosphate 5-phosphatase family contributes to tumorigenesis and tumor progression. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphatidylinositols (Phosphatidylinositol)
3.	Enzymes
4.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
5.	Amino Acids
6.	Phosphoric Monoester Hydrolases (Phosphatases)
7.	Lipids
8.	Insulin (Novolin)
9.	Phosphotransferases (Kinase)
10.	Inositol Polyphosphate 5-Phosphatases