Phosphoric Monoester Hydrolases (Phosphatases)

01/01/2004 - "In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance. "
01/01/2011 - "Expression and clinical role of protein of regenerating liver (PRL) phosphatases in ovarian carcinoma."
10/09/1989 - "Modulation of alkaline phosphatases in LoVo, a human colon carcinoma cell line."
10/01/1988 - "Discriminative value of serum phosphatases in patients with prostatic carcinoma."
01/01/1988 - "It is concluded that bone scintigraphy is far more sensitive than either radiographic survey or determination of prostatic acid phosphatases in the diagnosis of skeletal involvement in prostatic carcinoma, and should be the method of choice for this purpose."

05/01/1991 - "Records from 277 patients were reviewed retrospectively to determine the serum acid and alkaline phosphatases, the presence or absence of bone pain, and the results of bone scans and other radiographic studies at the time of initial diagnosis. "
05/01/2003 - "PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases."
05/01/2003 - "Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. "
05/01/1991 - "These results suggest that a routine bone scan to stage patients with newly diagnosed prostate cancer who have no bone pain and normal acid and alkaline phosphatases may not be warranted in all cases."
02/01/2001 - "Cyclic intravenous disodic pamidronate administration improved the clinical status (fracture incidence, pain, growth curve) and biological status (bone density, osseous alkaline phosphatases, urinary desoxypiridoline excretion), allowing a remarkable recovery. "

01/01/2015 - "Voltage sensitive phosphatases (VSPs), including engineered voltage sensitive PTEN, are excellent tools to rapidly and reversibly alter the phosphoinositide (PI) content of the plasma membrane in vivo and study the tumor suppressor PTEN. "
10/18/2002 - "This study also reveals that JNK phosphatases are potential targets for the development of novel cancer therapeutic agents."
12/01/1985 - "[Focusing into tumor and/or fetal-associated alkaline phosphatases and its translocation mechanism to blood stream--recent progress in studies on alkaline phosphatases]."
10/01/1973 - "The data from the present study strongly support the hypothesis that the tumor and the placental alkaline phosphatases are products of the same gene."
01/01/1963 - "[COMPARATIVE HISTOCHEMICAL STUDIES ON THE ACTIVITY OF PHOSPHATASES IN TRANSPLANTABLE TUMORS AND THEIR HOMOLOGOUS NORMAL TISSUES]."

05/01/2013 - "Taken together this study provides evidence for mycorrhizal alkaline phosphatases playing a role in P mobilisation from organic substrates under P starvation conditions."
12/01/2012 - "The study also indicated that overexpression of GbWRKY1 caused plants constitutively exhibited Pi starvation response including increased development of LR, relatively high level of total P and Pi, high expression level of some high-affinity Pi transporters and phosphatases as well as enhanced accumulation of acid phosphatases activity during Pi-sufficient. "
12/01/2014 - "The induction and secretion of acid phosphatases (APases) is a universal response of plants to phosphate (Pi) starvation. "
07/01/2012 - "In this work, an Arabidopsis mutant, hps4, was characterized that exhibits enhanced responses to Pi starvation, including increased inhibition of primary root growth, enhanced expression of Pi starvation-induced genes, and overproduction of root-associated acid phosphatases. "
06/01/2012 - "Response of alkaline phosphatases in the cyanobacterium Anabaena sp. FACHB 709 to inorganic phosphate starvation."

01/01/2009 - "Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes."
01/01/2005 - "Activation of stress kinases and phosphatases by this cytokine contribute to insulin resistance. "
01/01/2009 - "The results indicate that these lipid phosphatases possess different characteristics according to the time and preference of Akt isoform-dependent signaling in the negative regulation of the metabolic actions of insulin, whereas both inhibitions are effective in the amelioration of insulin resistance caused by TNF-alpha."
06/01/2002 - "This review covers the evidence suggesting that cytosolic accumulation of this active form of lipid in muscle can lead to impaired insulin signaling, impaired enzyme activity, and insulin resistance, either directly or by conversion to other lipid intermediates that alter the activity of key kinases and phosphatases. "
06/01/2006 - "Emerging evidence suggests that insulin resistance and its associated metabolic dyslipidemia result from perturbations in key molecules of the insulin signaling pathway, including overexpression of key phosphatases, downregulation and/or activation of key protein kinase cascades, leading to a state of mixed hepatic insulin resistance and sensitivity. "