Phosphatidylinositols (Phosphatidylinositol)

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.

Also Known As:

Networked: 1536 relevant articles (25 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dennis, Phillip A: 6 articles (07/2011 - 02/2003)
2.	Nussbaum, Robert L: 6 articles (03/2011 - 12/2002)
3.	Balu-Iyer, Sathy V: 5 articles (02/2015 - 09/2010)
4.	Takenawa, Tadaomi: 5 articles (04/2012 - 04/2004)
5.	Payrastre, Bernard: 5 articles (01/2012 - 10/2002)
6.	Elmendorf, Jeffrey S: 5 articles (09/2011 - 09/2004)
7.	Byrd, John C: 4 articles (05/2014 - 01/2009)
8.	Zhang, Wei: 4 articles (04/2014 - 01/2010)
9.	Balla, Tamas: 4 articles (02/2014 - 01/2009)
10.	Itoh, Toshiki: 4 articles (04/2012 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "In this study, we describe a novel cell lysis mechanism for fungal and tumor cells by the plant defensin NaD1 that acts via direct binding to the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). " 08/01/2007 - "To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking this key phosphatidylinositol 3'-kinase pathway regulator in their osteo-chondroprogenitors. " 01/01/2007 - "These studies demonstrate that activation of PI3K signaling by mutations in PTEN or PIK3CA can lead to activation of p53-mediated growth suppression in human cells, indicating that p53 can function as a brake on phosphatidylinositol (3,4,5)-triphosphate-induced mitogenesis during human cancer pathogenesis." 02/01/2015 - "In addition, the phosphatidylinositol 3‑kinase (PI3K)/Akt signaling pathway, which is closely associated with cellular metabolism, affects cancer biology. " 05/25/2014 - "Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation."
2.	Alzheimer Disease (Alzheimer's Disease) 05/01/2007 - "These results suggest that soybean-derived phosphatidylinositol may be effective in the treatment of Alzheimer's disease." 07/01/2003 - "The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease." 01/01/1995 - "The present article focuses on our studies on the metabolism of the inositol phospholipids in Alzheimer disease (AD). " 03/01/1994 - "The effect of Alzheimer's disease (AD) on the activity of the phosphoinositide second messenger system was studied by measuring the hydrolysis of [3H]phosphatidylinositol (PI) by membranes from postmortem human prefrontal cortex. " 11/01/1992 - "The cortical areas that are morphologically affected by Alzheimer's disease, i.e., frontal and temporal cortex and the hippocampus, showed elevated contents of lipid solvent-extractable phosphatidylinositol. "
3.	Infection 06/01/2015 - "In this chapter, we review the molecular strategies that major pathogens including Listeria, Mycobacterium, Shigella, Salmonella, Legionella and Yersinia use to hijack phosphoinositides during infection. " 03/01/2015 - "Phosphatidylinositol inhibits respiratory syncytial virus infection." 11/12/2014 - "Infection also required ER-associated PI4P phosphatase Sac1 and phosphatidylinositol (PI) transfer protein beta (PITPb) shunting PI between ER-Golgi. " 01/01/2014 - "Decreasing levels of phosphatidylinositol in cell membranes combined with the increased expression of genes related with T-cell signalling pathways revealed new interactions between dietary lipid composition and the immune response in fish during viral infection. " 09/01/2013 - "Together, our results support the hypothesis that Phytophthora species produce external PtdIns(3)P to aid in infection, such as to promote entry of RxLR effectors into host cells. "
4.	Bipolar Disorder (Mania) 01/01/2014 - "In addition, we identified in the French cohort one affected individual with a deletion at the PLCXD3 locus and another one carrying a missense variation in PLCXD3 (p.R93H), both supporting a role of the phosphatidylinositol pathway in early-onset bipolar disorder vulnerability. " 02/01/2007 - "Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS). " 03/24/1997 - "Abnormalities in the cellular phosphatidylinositol (PI) pathway have been proposed to be implicated in the pathophysiology of bipolar disorder. " 01/01/1997 - "Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients." 03/15/1996 - "Abnormal phosphatidylinositol (PI)-signalling in bipolar disorder."
5.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 11/01/1999 - "Inositol, an isomer of glucose and precursor in the phosphatidylinositol cycle, may be effective in a number of psychiatric disorders, including obsessive-compulsive disorder (OCD). " 07/01/2002 - "Inositol, a simple isomer of glucose, which serves as a precursor in the phosphatidyl-inositol (PI) second messenger cycle, was shown to be effective in double-blind, placebo-controlled studies of depression, panic and obsessive compulsive disorders as well as in bulimia. " 06/01/2001 - "myo-Inositol, a natural isomer of glucose and a precursor for the second-messenger phosphatidyl-inositol system, has previously been found superior to placebo in the treatment of depression, panic disorder, and obsessive-compulsive disorder (OCD), but a direct comparison with an established drug has never been performed. "

Related Drugs and Biologics

1.	Inositol (Myoinositol)
2.	Phosphotransferases (Kinase)
3.	Protein Kinase C
4.	Phosphatidylinositols (Phosphatidylinositol)
5.	Glucose (Dextrose)
6.	Protein Kinases (Protein Kinase)
7.	Proteins (Proteins, Gene)
8.	Phosphatidylinositol 3-Kinases
9.	Type C Phospholipases
10.	Desoxycorticosterone (DOCA)

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Therapeutics
5.	Aftercare (After-Treatment)