Chondrocalcinosis 2

A hereditary autosomal dominant form of chondrocalcinosis that is caused by mutations in the ANKH gene. OMIM: 118600

Also Known As:

CCAL2; CPPDD; CPPDD Calcium Pyrophosphate Dihydrate Deposition Disease; Calcium Gout; Calcium Pyrophosphate Arthropathy; Calcium Pyrophosphate Dihydrate Deposition Disease; Chondrocalcinosis, Familial Articular

Networked: 30 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Joint Diseases: 6509
  - Arthritis: 33467
    - Chondrocalcinosis: 664
      - Chondrocalcinosis 2: 30
  - Crystal Arthropathies: 176
    - Chondrocalcinosis: 664
      - Chondrocalcinosis 2: 30

Related Diseases

1.	Chondrocalcinosis (Pseudogout)
2.	Crystal Arthropathies
3.	Osteoarthritis
4.	Synovitis
5.	Joint Diseases (Joint Disease)

Experts

1.	Filippucci, Emilio: 2 articles (07/2017 - 11/2013)
2.	Grassi, Walter: 2 articles (07/2017 - 11/2013)
3.	Johnson, Mahlon: 2 articles (10/2012 - 04/2012)
4.	Srinivasan, Vasisht: 2 articles (10/2012 - 04/2012)
5.	Beier, Frank: 2 articles (06/2009 - 01/2008)
6.	Tsui, Florence W L: 2 articles (06/2009 - 01/2008)
7.	Tsui, Hing Wo: 2 articles (06/2009 - 01/2008)
8.	Wang, John: 2 articles (06/2009 - 01/2008)
9.	Bassetto, Franco: 1 article (03/2022)
10.	Costa, Alfio Luca: 1 article (03/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chondrocalcinosis 2:

1.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 11/01/2013 - "Extent and distribution of CPP deposits in patients affected by calcium pyrophosphate dihydrate deposition disease: an ultrasonographic study." 07/01/2017 - "To compare the diagnostic accuracy of musculoskeletal ultrasound (MSUS) and x-ray in evaluating wrist triangular fibrocartilage complex (TFCC) in patients with calcium pyrophosphate dihydrate deposition disease (CPPD) and to investigate the agreement between the extent of the calcium pyrophosphate dihydrate (CPP) crystal deposits assessed by MSUS and the radiographic findings. " 03/12/2022 - "BACKGROUND Calcium pyrophosphate dihydrate deposition disease includes a variety of clinical syndromes, including acute calcium pyrophosphate (CPP) crystal arthritis. "
2.	DNA (Deoxyribonucleic Acid)IBA 12/01/1999 - "Genomic DNA studies in these kindred with secondary or primary form of CPPDD provide a shortcut for trying to investigate the biomolecular basis of the disease. "
3.	Calcium PyrophosphateIBA 05/01/2013 - "Calcium pyrophosphate dihydrate crystal deposition disease (CPPDD) is a rare benign inflammatory joint disorder characterized by the presence of calcium pyrophosphate dihydrate crystal in the interarticular and periarticular tissue. " 12/01/1999 - "The mechanisms involved in calcium pyrophosphate dehydrated deposition disease (CPPDD) are unknown and those families with the disease, described in different countries, provide a fertile file for genomic research. " 06/01/2009 - "Numerous dominant human homolog of progressive ankylosis (ANKH) mutations have been identified in familial calcium pyrophosphate dihydrate crystal deposition disease (CPPDD). " 07/01/2003 - "Calcium pyrophosphate dihydrate (CPPD) deposition disease (CPPDD), also known as pseudogout, is rarely known to affect the spine. " 08/01/2010 - "Calcium pyrophosphate dihydrate deposition disease (CPPD), also known as pseudogout or chondrocalcinosis, is a variety of metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate crystals in and around joints. "
4.	diphosphoric acid (pyrophosphoric acid)IBA 08/01/1989 - "The disordered production of inorganic pyrophosphate (PPi) by articular cartilage is thought to have an important role in the pathogenesis of calcium pyrophosphate dihydrate deposition disease and perhaps osteoarthritis. " 11/01/2014 - "Calcium pyrophosphate dihydrate deposition disease (pseudogout) is a crystal arthritis characterized by pyrophosphate dihydrate crystal deposition in the articular cartilage or synovium. " 04/01/2012 - "Calcium pyrophosphate dihydrate deposition disease (CPDD, tophaceous pseudogout) is a rare crystal arthropathy characterized by pyrophosphate crystal deposition in joints, synovitis and chondrocalcinosis on imaging. " 09/01/2004 - "Numerous ANKH gene mutations cause familial CCAL2; they enhance ANKH protein activity, thereby elevating extracellular pyrophosphate levels and promoting the formation of pyrophosphate crystals, which produce the manifestations of the disease. "
5.	Proteins (Proteins, Gene)FDA Link 06/01/2009 - "Due to the dominant nature of these mutations, we investigated whether ANKH interacts with other proteins; and if so, whether any CPPDD-associated ANKH mutation might disrupt such protein interactions. " 10/01/2002 - "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH." 09/01/2004 - "Numerous ANKH gene mutations cause familial CCAL2; they enhance ANKH protein activity, thereby elevating extracellular pyrophosphate levels and promoting the formation of pyrophosphate crystals, which produce the manifestations of the disease. "
6.	CalciumIBA 06/01/2012 - "The acute calcium deposit belongs to the group of calcium pyrophosphate dihydrate deposition disease (CPPD). " 01/01/1999 - "Familial calcium pyrophosphate dihydrate deposition disease (CPPDD) is a disease of articular cartilage that is radiographically characterized by chondrocalcinosis due to the deposition of calcium-containing crystals in affected joints. "
7.	Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)IBA 06/01/2009 - "The CPPDD-associated ANKH M48T mutation interrupts the interaction of ANKH with the sodium/phosphate cotransporter PiT-1."
8.	Durapatite (Hydroxylapatite)IBA 05/01/2006 - "The three most common types of crystal-induced arthropathy are gout, calcium pyrophosphate dihydrate deposition disease, and calcium hydroxyapatite deposition disease. "
9.	Uric Acid (Urate)IBA 07/01/2014 - "Compare urate levels in the serum and SF of gouty arthritis, calcium pyrophosphate dihydrate deposition disease (CPPD), rheumatoid arthritis (RA), septic arthritis, ankylosing spondylitis (AS), and osteoarthritis (OA) patients. "
10.	Proteoglycans (Proteoglycan)IBA 09/01/1987 - "Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. "

Therapies and Procedures

1.	Knee Replacement Arthroplasty (Total Knee Replacement) 02/01/2007 - "The authors report a case of calcium pyrophosphate dihydrate deposition disease (pseudogout) presenting in the early period after primary total knee arthroplasty. " 02/01/2007 - "Calcium pyrophosphate dihydrate deposition disease (pseudogout) after total knee arthroplasty."
2.	Replacement Arthroplasty 08/01/2016 - "Calcium Pyrophosphate Dihydrate Deposition Disease in a Knee With Total Joint Replacement."
3.	Therapeutics 08/11/1967 - "["Calcium gout" with nephrocalcinosis due to long-term dihydrotachysterine therapy]."
4.	Renal Dialysis (Hemodialysis) 01/01/2017 - "We report a case of calcium pyrophosphate dihydrate deposition disease (CPDD) involving a patient on maintenance hemodialysis (MHD). "
5.	Craniotomy 06/01/2007 - "Cervical tumoral calcium pyrophosphate dihydrate deposition disease 28 years after suboccipital craniotomy: case report."