HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Uric Acid (Urate)

An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

Also Known As:

Urate; 2,6,8-Trihydroxypurine; Ammonium Acid Urate; Monosodium Urate; Monosodium Urate Monohydrate; Potassium Urate; Sodium Acid Urate; Sodium Acid Urate Monohydrate; Sodium Urate; Sodium Urate Monohydrate; Trioxopurine; Acid Urate, Ammonium; Acid Urate, Sodium; Acid, Uric; Monohydrate, Monosodium Urate; Monohydrate, Sodium Urate; Urate Monohydrate, Monosodium; Urate Monohydrate, Sodium; Urate, Ammonium Acid; Urate, Monosodium; Urate, Potassium; Urate, Sodium; Urate, Sodium Acid; 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-

Networked: 8589 relevant articles (322 outcomes, 1072 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Alkaloids: 1065
  - Xanthines: 95
    - Uric Acid: 8589
- 2-Ring Heterocyclic Compounds
  - Purines: 436
    - Purinones
      - Xanthines: 95
        Uric Acid: 8589
        1,3-dimethyluric acid: 7
        1-methyluric acid: 6
        1,3,7,9-tetramethyluric acid: 2
        5-hydroxyisourate: 1
        uric acid riboside: 1
        1,3,7-trimethyluric acid
        1,7-dimethyl-8-oxoenprofylline
        1,7-dimethyluric acid
        2,6-dithiouric acid
        2-thiouric acid
        3,7-dimethyluric acid
        3-N-ribosyluric acid 5'-monophosphate
        4,5-dihydro-4,5-dihydroxyuric acid
        5-hydroxy-pseudouric acid
        6-thiouric acid
        8-oxoenprofylline
        9-methyluric acid
        9-N-ribofuranosyluric acid
        9-N-ribofuranosyluric acid 5'-monophosphate
        Reye's syndrome serum factor

Experts

1.	Johnson, Richard J: 109 articles (01/2016 - 06/2002)
2.	Dalbeth, Nicola: 75 articles (01/2016 - 09/2007)
3.	Schumacher, H Ralph: 37 articles (01/2016 - 03/2005)
4.	Ichida, Kimiyoshi: 33 articles (10/2015 - 01/2007)
5.	Choi, Hyon K: 31 articles (10/2015 - 05/2005)
6.	Nakagawa, Takahiko: 29 articles (09/2015 - 09/2002)
7.	Perez-Ruiz, Fernando: 27 articles (01/2016 - 08/2002)
8.	Kang, Duk-Hee: 27 articles (10/2014 - 09/2002)
9.	Becker, Michael A: 26 articles (10/2015 - 07/2003)
10.	Stamp, Lisa K: 25 articles (01/2016 - 12/2010)

Related Diseases

1.	Gout 07/01/2001 - "In addition, after lead chelating therapy, urate clearance markedly improved after a reduction of the BLS of patients with CRI and gout (study group 67.9 +/- 80.0% vs. control group 1.2 +/- 34.0%, P = 0.0056). " 03/01/1992 - "This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout." 07/01/2000 - "In this study it was investigated whether dietary measures, reported to be beneficial in IR, have serum uric acid (SU) and lipid lowering effects in gout. " 06/01/2007 - "Successful management of chronic gout depends on reducing body pools of urate. " 01/01/1998 - "Interestingly, no significant rise in the plasma, urinary and clearance of uric acid was observed in gout patients with uric acid clearance > 6.0 mL/min (lower normal limit). "
2.	Hyperuricemia 10/01/2013 - "Small clinical trials have suggested that uric acid-lowering therapies may be beneficial in such patients; however, a consensus on the treatment of asymptomatic hyperuricemia is lacking. " 04/01/2012 - "Overall serum uric acid (UA) concentration increased, whereas in patients with hyperuricemia there was a significant reduction in this value. " 10/01/2008 - "Early screening for hyperuricemia and lowering serum uric acid levels might be beneficial in slowing progression of IMT in hypertensive patients." 03/01/2014 - "Better understanding of the transporters URAT1 and ABCG2 in particular would appear to provide opportunities for more selective, better tolerated agents to increase the renal clearance of uric acid and thereby control hyperuricemia. " 10/23/2015 - "Measurement of salivary UA is a noninvasive and useful way for monitoring the status of hyperuricemia and the therapeutic efficacy of urate-lowering therapy. "
3.	Hypertension (High Blood Pressure) 01/01/1991 - "There was a marked decrease in urate excretion per nephron in hyperuricemic patients with essential hypertension. " 01/01/2015 - "This paper presents and discusses the epidemiological correlation between high serum uric acid levels and hypertension, and reviews current evidence supporting the protective effects of the normalization of uric acid levels. " 05/01/2001 - "Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. " 10/01/2015 - "The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population. " 03/01/2015 - "The purpose of this study was to examine the associations between serum uric acid (SUA) levels and the incidences of hypertension and metabolic syndrome (MetS) in a large screened cohort of Japanese men and women. "
4.	Inflammation 05/01/2015 - "Although many evidence-based studies have suggested that uric acid itself may harm patients with CKD by increasing inflammation and CKD progression, the issue is still a matter of controversy. " 01/01/2015 - "In this study, the involvement of TG2 in monosodium urate (MSU) crystal-induced inflammation was studied. " 12/01/2014 - "Elevated serum levels of uric acid induce renal injury via an inflammation response, but the detailed mechanism is still under study. " 01/01/2014 - "We found in our study that increased CRP, uric acid and RDW levels, which are indicators of increased inflammation and oxidative stress, are significantly higher in the non-dipper HT patients in comparison to the dipper HT patients and control group." 07/01/2013 - "Twenty-five out of 41 trials, involving 23 different herbal prescriptions, found statistical significance in lowering serum uric acid level, and the overall effect from Chinese herbal medicine in inflammation relief is better than conventional therapies in 19 trials with 17 different prescriptions. "
5.	Body Weight (Weight, Body) 04/01/1990 - "The younger the child, the greater the renal clearance of uric acid and the greater the excretion of uric acid expressed as mg per kg body weight. " 06/01/1992 - "Treatment with uric acid, at doses of 50, 100 or 300 mg/kg body weight, by gavage, provided some measure of protection against all of these effects, and the protection was generally dose dependent. " 06/01/1992 - "Uric acid at doses of 50, 100 or 300 mg/kg body weight provided dose-dependent protection against the ulcerogenic effects of all three agents. " 01/01/2014 - "Study participants included 21 men with a mean age of 52.1 years, mean weight of 91.1 kg, and mean total fat mass of 24.3 kg. Twenty-four-hour urine pH and SI uric acid were more closely correlated with fat mass than with lean mass or total body weight. " 01/01/2015 - "Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. "

Related Drugs and Biologics

1.	Allopurinol (Remid)
2.	Uric Acid (Urate)
3.	Creatinine
4.	Urea (Carbamide)
5.	Xanthine Oxidase
6.	febuxostat
7.	Calcium
8.	Glucose (Dextrose)
9.	Blood Glucose (Blood Sugar)
10.	rasburicase (Elitek)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Transplantation (Transplant Recipients)
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)