4-phenylbutylamine

06/01/2019 - "A part of hypoxia-treated L02 cells was applied with 4-PBA 1 h before exposure to hypoxia. "
03/14/2019 - "In vitro, pharmacological inhibition of ER stress by 4-PBA limited hypoxia-induced EMT. "
01/05/2015 - "In the primary cultured neonatal rat cardiomyocytes or fibroblasts, hypoxia (3% O2) increased the number of apoptotic cardiomyocytes and promoted the proliferation and migration of fibroblasts, all of which were attenuated by 4-PBA (0.5 mM). "
11/01/2023 - "Conversely, the protective effect of 4-PBA against hypoxia/reoxygenation injury in cardiomyocytes was offset by STING overexpression, wherein the activated STING-IRF3 pathway promoted the expression of Rubicon (a negatively-regulated autophagic molecule) by binding to the Rubicon promoter. "
03/01/2023 - "Treatment with 4-PBA, inhibitor of ER stress, effectively attenuated hypoxia-induced lipolysis via cAMP-PKA-HSL/perilipin pathway. "

02/01/2023 - "In conclusion, we found that Cd was involved in mitochondrial dysfunction, ERS, and apoptosis in MC3T3-E1 cells, While NAC and 4-PBA relieved ERS and attenuated cell apoptosis."
10/26/2021 - "Furthermore, the inhibition of ER stress by the inhibitor 4-PBA improved mitochondrial dysfunction, reduced oxidative stress, and reversed cardiac remodeling and dysfunction in cultured cardiomyocytes or in CGI-58cko mice. "
12/01/2021 - "gondii and ESP challenge-induced mitochondrial dysfunction and cell death were dramatically suppressed in 4-PBA pretreated cells. "
07/01/2017 - "4-PBA attenuated ER stress and mitochondrial dysfunction induced by Dex in MC3T3-E1 cells. "
01/01/2021 - "Finally, low CSE levels in AngII-induced HL-1 cells were concentration- and time-dependent and associated with mitochondrial dysfunction, apoptosis, the Warburg effect and ERS, and these effects were reversed by NaHS, DCA or 4-PBA supplementation. "

09/25/2023 - "Encouragingly, 4-PBA administration also improved bone formation and attenuated osteolysis in a mouse calvarial model. "
12/25/2020 - "After adding 4-PBA, an inhibitor of endoplasmic reticulum stress (4-PBA), on the basis of wear particles TiNPs, the symptoms of osteolysis were significantly relieved, bone erosion and inflammatory infiltration were significantly reduced, the differentiation and maturation of osteoblasts were improved, the number of apoptotic osteoblasts decreased sharply, and the expression of endoplasmic reticulum stress marker protein gradually decreased. "
08/01/2018 - "SIRT1 activator RES and ER stress inhibitor 4-PBA significantly suppressed PE particle-induced osteoclast differentiation and osteolysis. "
08/01/2018 - "To address this, an osteolysis mouse model was used in which animals were treated with the SIRT1 activator, resveratrol (RES), or an ER stress inhibitor, 4-PBA, for two weeks. "

11/01/2017 - "The protective effects of 4-PBA were nullified by suppression of Akt and mTOR in adipocytes, suggesting that 4-PBA inhibits autophagy and restores insulin sensitivity via Akt/mTOR signaling partially. "
01/25/2014 - "Moreover, both 4-PBA and knock-down of SeP improved CGN-induced insulin resistance. "
11/01/2017 - "4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling partly, which could be regarded as novel opportunities for treatment of insulin resistance."
11/01/2017 - "However the mechanism of 4-PBA involved in insulin resistance remains elusive. "
11/01/2017 - "4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling."

04/05/2017 - "Taken together, our study indicated that ER stress is a key promoter in the induction of inflammation by LPS, the protective effect of 4-PBA is related to the inhibition of ER stress and autophagy in LPS-induced ALI models. "
10/23/2023 - "4-PBA trained monocytes can effectively propagate anti-inflammation activity to neighboring monocytes through CD24. "
02/01/2021 - "Both interferences with miR-211-5p agomir and 4-PBA effectively attenuated neuron apoptosis and reversed the expressions of apoptosis, inflammation and endoplasmic reticulum stress-related molecules post SCI in rats. "
02/01/2021 - "We also demonstrated that PA could induced inflammation-related genes in CIK cells, and the PA-induced inflammation were alleviated by 4-PBA. "
01/01/2021 - "In EDN ECs, 4-PBA downregulated the expression of sEH and VCAM1, suppressed inflammation, and its application in vivo reduced atherosclerotic lesions of EDN mice. "