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Spinal Injections

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Also Known As:

Injections, Spinal; Injection, Intraspinal; Injection, Intrathecal; Injection, Spinal; Intraspinal Injection; Intrathecal Injection; Spinal Injection; Injections, Intraspinal; Injections, Intrathecal; Intraspinal Injections; Intrathecal Injections

Networked: 1054 relevant articles (38 outcomes, 85 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Drug Therapy: 178671
  - Drug Administration Routes: 9
    - Injections: 26272
      - Spinal Injections: 1054
        Epidural Injections: 632

Experts

1.	Ji, Ru-Rong: 16 articles (05/2015 - 01/2002)
2.	Eisenach, James C: 16 articles (01/2013 - 01/2002)
3.	Gao, Yong-Jing: 13 articles (10/2015 - 04/2009)
4.	Ma, Zhengliang: 9 articles (10/2015 - 01/2012)
5.	Gu, Xiaoping: 9 articles (10/2015 - 01/2012)
6.	Yaksh, Tony L: 9 articles (02/2014 - 10/2002)
7.	Maier, Steven F: 9 articles (10/2013 - 03/2005)
8.	Watkins, Linda R: 9 articles (10/2013 - 03/2005)
9.	Zhang, Wei: 8 articles (07/2015 - 03/2009)
10.	Pan, Hui-Lin: 8 articles (06/2015 - 11/2003)

Related Diseases

1.	Pain (Aches) 01/01/2009 - "To determine the effect of intravenous sedation on postprocedural pain relief for patients undergoing a spinal injection procedure in which there is no expectation of immediate relief. " 10/01/2013 - "This study showed that regular breathing can significantly reduce the pain of intrathecal injection in leukemic children, especially in those aged above 10 years. " 10/01/2013 - "In the present study, the effectiveness of regular breathing method (Hey-Hu) in reduction of pain of intrathecal injection in leukemic children was evaluated. " 01/01/2013 - "This study aimed at investigating the role of Stat3 on neuroinflammation during development of pain in rats after intrathecal injection of lipopolysaccharide (LPS). " 01/01/2010 - "This observational, prospective, national study was carried out among a French national representative database of primary rheumatologists to evaluate the prevalence and intensity of pain caused by intra-and peri-articular injections, synovial fluid aspirations, soft tissue injections, and spinal injections. "
2.	Hyperalgesia 10/01/2010 - "Previous studies have shown that intrathecal injection of AM induced hyperalgesia in the rat. " 11/01/2015 - "Overexpression of miR‑141 by intrathecal injection of miR‑141 precursor mediated by a lentivirus‑derived gene transfer significantly inhibited mechanical allodynia, thermal hyperalgesia and proinflammatory cytokine release in CCI rats. " 07/01/2015 - "After treatment with intrathecal injection (i.t.), mechanical and thermal hyperalgesia in the CCI+IMD1-53 group was maintained, but MWT and TWL in the CCI+IMD14-47 groups increased. " 04/01/2015 - "The cold allodynia was also significantly reduced by intrathecal injections of 0.5 (P < 0.05) and 1 µg (P < 0.001) of SHG. " 02/01/2015 - "Furthermore, the intrathecal injection of siRNA1-GPNMB inhibited the expression of GPNMB and pro-inflammatory factors (TNF-α, IL-1β, and IL-6) and alleviated mechanical allodynia and thermal hyperalgesia in the chronic constriction injury (CCI) model of rats. "
3.	Neuralgia (Stump Neuralgia) 02/13/2013 - "The current study shows that an intrathecal injection of the TRESK gene recombinant adenovirus attenuated the activity of astrocytes in spinal cord, which contributed to relieving neuropathic pain in spared nerve injury rats. " 03/20/2014 - "The current findings suggest that the inhibition of neuropathic pain manifestations by intrathecal injection of CBX in SNL rats may involve an inhibition of glial gap junctions and an attenuation of WDR neuronal activity in the dorsal horn." 01/01/2013 - "Moreover, the intrathecal injection of 18:1 LPA, but not 16:0 or 18:0 LPA, caused a spinal LPA production and neuropathic pain-like behavior. " 02/01/2009 - "The balance between sympathetic and parasympathetic nervous activities could be well preserved in most cases, except for 35 mg/kg. Considering the ratio between useful effects and side effects, doses of 15 mg/kg are suitable for intrathecal injection for relief of neuropathic pain." 09/01/2005 - "Intrathecal injection of RSEP1 antisense oligonucleotide into the spinal cord lumbar enlargement attenuated neuropathic pain behaviours in CCI rats, suggesting a functional involvement of RSEP1 in neuropathic pain."
4.	Hypersensitivity (Allergy) 01/23/2009 - "Further, intrathecal injection of soluble CD14 induced significantly greater mechanical hypersensitivity in wild type (C3H/HeN) mice compared with TLR4-deficient (C3H/HeJ) mice. " 01/01/2016 - "In contrast, intrathecal injection of CSF1 induced mechanical hypersensitivity and microglial proliferation. " 08/01/2015 - "C57Bl6 mice were given intrathecal injections of small interfering RNAs to reduce levels of TRPV4, or control small interfering RNAs, along with colonic injections of biopsy supernatants; visceral hypersensitivity was measured based on response to colorectal distension. " 07/01/2014 - "Intrathecal injection of desCER induced a dose-dependent mechanical hypersensitivity but not heat or cold hypersensitivity. " 03/20/2014 - "Intrathecal injection of CBX dose-dependently (0.1-50 μg, 10 μl) inhibited mechanical hypersensitivity in rats at 2-3 weeks post-SNL. "
5.	Leukemia 06/01/2005 - "The objective of this prospective 18-month study was to evaluate the clinical and laboratory effects of repeated intrathecal injections of chemotherapy in children with acute leukemia. " 05/18/1979 - "11 patients experienced 40 intrathecal injections of cytotoxic drugs during the treatment of acute leukemia. " 01/01/2015 - "In this study, we tried to find a safe as well as fast effective treatment for sedation and analgesia for intrathecal injection in childhood leukemia patients, relieving treatment difficulties and pain, increasing the success rate of single intrathecal injection.The" 07/29/1993 - "Patients were considered to have central nervous system leukemia at diagnosis if they had at least 5 leukocytes per microliter of cerebrospinal fluid, with leukemic blast cells apparent in cytocentrifuged preparations, or cranial-nerve palsy; they received additional intrathecal injections of chemotherapeutic agents and cranial irradiation. " 01/20/1990 - "These findings suggest that intermediate dose Ara-C therapy was effective to overcome a resistance to antileukemic drugs, including Ara-C, and also, in some cases, more effective than intrathecal injection of antileukemic drugs for the treatment of CNS leukemia."

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Bupivacaine (Bupivacaine Hydrochloride)
3.	Tissue Plasminogen Activator (Alteplase)
4.	crystalloid solutions
5.	N-Methylaspartate (NMDA)
6.	Fentanyl (Sublimaze)
7.	Midazolam (Versed)
8.	Ondansetron (Zofran)
9.	Baclofen
10.	U 0126 (UO 126)

Related Therapies and Procedures

1.	Analgesia
2.	Ligation
3.	Drug Therapy (Chemotherapy)
4.	Intravenous Injections
5.	Acupuncture Points (Acupuncture Point)