HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

myosin VI

a 6th class of myosin motors; composed of porcine myosin-VI and Drosophila 95F myosin; amino acid sequence in first source; GenBank Z35331 (Sus scrofa); RefSeq NM_004999 (human), NM_008662 (rat)

Also Known As:

95F unconventional myosin protein, Drosophila; DFNA22 protein, human; DFNB37 protein, human; MYO6 protein; MYO6 protein, human; Mhc95F protein, Drosophila; Myo6 protein, mouse; MyoVI protein; MyoVI protein, Drosophila; jaguar protein, Drosophila; jar protein, Drosophila; myosin 95F protein, Drosophila; myosin VI protein, human; myosin VI protein, mouse; myosin-VI

Networked: 61 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sweeney, H Lee: 4 articles (03/2015 - 01/2008)
2.	Buss, Folma: 4 articles (04/2008 - 01/2004)
3.	Kendrick-Jones, John: 4 articles (04/2008 - 01/2004)
4.	Lanahan, Anthony A: 2 articles (08/2015 - 09/2008)
5.	Simons, Michael: 2 articles (08/2015 - 09/2008)
6.	Song, Lin: 2 articles (03/2015 - 01/2008)
7.	Takarada, Takeshi: 2 articles (01/2013 - 09/2009)
8.	Nakamichi, Noritaka: 2 articles (01/2013 - 09/2009)
9.	Ogura, Masato: 2 articles (01/2013 - 09/2009)
10.	Ito, Yuma: 2 articles (01/2013 - 09/2009)

Related Diseases

1.	Stroke (Strokes) 10/27/2009 - "Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm." 01/09/2008 - "The post-rigor structure of myosin VI and implications for the recovery stroke." 01/16/2007 - "To experimentally map out the motion of the converter domain and lever arm, we have generated a series of truncated myosin VI constructs and characterized the size and direction of the power stroke for each construct using dual-labeled gliding filament assays and optical trapping. " 01/16/2007 - "However, this redirection alone is insufficient to account for the large (-)-end-directed stroke of a monomeric myosin VI construct. " 01/16/2007 - "The power stroke of myosin VI and the basis of reverse directionality."
2.	Neoplasms (Cancer) 05/25/2004 - "Optical imaging and histopathologic studies revealed that inhibiting myosin VI expression reduces tumor dissemination in nude mice. " 12/01/2010 - "Therefore, in contrast to differentiated leukocytes and cells from solid tumors, myosin VI plays a crucial role in the migration of leukemic cells." 08/27/2010 - "We also found that the levels of myosin VI protein were markedly inhibited in MCF7 cells by wild-type p53 but not tumor-derived mutant p53. " 11/01/2006 - "Using expression microarrays, we identified myosin VI as one of the top genes that demonstrated cancer-specific overexpression in clinical prostate specimens. " 04/25/2008 - "Understanding the functions of myosin VI within the cell and how it is regulated is now of utmost importance given the recent observations that it is associated with a number of human disorders such as deafness and cancers."
3.	Ovarian Neoplasms (Ovarian Cancer) 05/25/2004 - "Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer." 05/25/2004 - "In this study, we found that myosin VI, a motor protein that regulates border cell migration, is abundantly expressed in high-grade ovarian carcinomas but not in normal ovary and ovarian cancers that behave indolently. " 10/01/2006 - "With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. "
4.	Hypertension (High Blood Pressure) 10/01/2005 - "This study aimed to determine whether the actin-based motor myosin VI coordinately retracts with NHE3 in response to acute hypertension. " 10/01/2005 - "These results provide the first observation that acute hypertension causes myosin VI redistribution and support the idea that myosin VI may serve as the molecular motor for NHE3 retraction from top to base of MV during acute hypertension." 10/01/2005 - "In acute hypertension, myosin VI decreased in z1 (from 20.6 +/- 1.9 to 10.5 +/- 2.3%) and z2 (from 21.0 +/- 2.0 to 13.2 +/- 1.4%) and increased in z5 (from 21.1 +/- 3.3 to 38.6 +/- 3.0%). " 10/01/2005 - "By confocal microscopy, myosin VI was detected over the whole length of the MV in controls, then became completely focused at the base of MV during acute hypertension. " 10/01/2005 - "During acute hypertension, myosin VI redistributed from low density apical MV-enriched membranes (from 23 +/- 2.4 to 11.4 +/- 2.2%) into higher density membranes (from 23.2 +/- 0.7 to 36.9 +/- 2.6%). "
5.	Hepatocellular Carcinoma (Hepatoma) 10/01/2015 - "This study highlights the potential of myosin VI to be developed as a target for hepatocellular carcinoma therapy. " 10/01/2015 - "The results demonstrated that myosin VI expression was much stronger in hepatocellular carcinoma tissues than in adjacent normal tissues. " 10/01/2015 - "Firstly, the expression of myosin VI was analyzed in 57 hepatocellular carcinoma samples and 10 non-neoplastic samples by immunohistochemistry. " 10/01/2015 - "Knockdown of Myosin VI Inhibits Proliferation of Hepatocellular Carcinoma Cells In Vitro." 10/01/2015 - "This study identified the short hairpin RNA-mediated silencing of myosin VI as a potential approach for the treatment of hepatocellular carcinoma. "

Related Drugs and Biologics

1.	Myosins (Myosin)
2.	Proteins (Proteins, Gene)
3.	Small Interfering RNA (siRNA)
4.	Nonsense Codon (Nonsense Mutation)
5.	myosin VIIa
6.	Myosin Type V
7.	Topoisomerase Inhibitors
8.	beta Catenin
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Cardiac Myosins