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allosamidin

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Also Known As:

A 82516; A-82516; A82516; beta-D-Allopyranoside, 2-(dimethylamino)-3a,5,6,6a-tetrahydro-4-hydroxy-6-(hydroxymethyl)-4H-cyclopentoxazol-5-yl 2-(acetylamino)-4-O-(2-(acetylamino)-2-deoxy-beta-D-allopyranosyl)-2-deoxy-, (3aalpha,4beta,5beta,6alpha,6aalpha)-

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 4088
- Polysaccharides: 2929
  - Oligosaccharides: 1372
    - Trisaccharides: 24
      - allosamidin: 7
- Amino Sugars: 30
  - Hexosamines: 62
    - Glucosamine: 1287
      - Acetylglucosamine: 531
        allosamidin: 7

Experts

1.	Sakuda, Shohei: 2 articles (01/2014 - 05/2011)
2.	Vinetz, J M: 2 articles (06/2001 - 04/2000)
3.	Pham, Alexa: 1 article (01/2014)
4.	Cho, Jae Youn: 1 article (01/2014)
5.	Broide, David H: 1 article (01/2014)
6.	Aceves, Seema: 1 article (01/2014)
7.	Miller, Marina: 1 article (01/2014)
8.	Rosenthal, Peter: 1 article (01/2014)
9.	Noda, Naotaka: 1 article (05/2011)
10.	Nagasawa, Hiromichi: 1 article (05/2011)

Related Diseases

1.	Uveitis 03/01/2008 - "AMCase inhibitors showed in this rabbit model of uveitis a notable control of inflammatory response with a significant reduction of AMCase activity in tears with caffeine and allosamidin. " 03/01/2008 - "The aim of the study was to investigate the effects of chitinase inhibitors, allosamidin and caffeine versus dexamethasone, in rabbit endotoxin-induced uveitis (EIU). "
2.	Malaria 06/01/2001 - "Moreover, PbCHT1 activity appeared insensitive to allosamidin inhibition, an observation that raises questions about the use of allosamidin and components like it as potential malaria transmission-blocking drugs. " 04/07/2000 - "Since the peritrophic matrix is a physical barrier that the parasite must cross to invade the mosquito, and the presence of allosamidin, a chitinase inhibitor, in a blood meal prevents the parasite from invading the midgut epithelium, chitinases (3.2.1.14) are potential targets of malaria parasite transmission-blocking interventions. " 05/01/1993 - "We found that allosamidin, a specific inhibitor of chitinase, completely blocked oocyst development in vivo and thus blocked malaria parasite transmission. "
3.	Avian Malaria 06/01/2001 - "Plasmodium chitinase activities are demonstrated targets for human and avian malaria transmission blockade with the chitinase inhibitor allosamidin. "
4.	Inflammation 01/01/2014 - "Oral allosamidin inhibited eosinophilic inflammation in the epithelium but did not inhibit esophageal remodeling. " 01/01/2014 - "We have used a mouse model of egg (OVA) induced EoE to determine whether pharmacologic inhibition of AMCase with allosamidin reduced eosinophilic inflammation and remodeling in the esophagus in EoE. " 01/01/2014 - "This inhibition of eosinophilic inflammation in the esophagus by ip allosamidin was associated with reduced eotaxin-1 expression in the esophagus. " 01/01/2014 - "Pharmacologic inhibition of AMCase with ip allosamidin inhibited both OVA induced increases in esophageal eosinophilic inflammation and OVA induced esophageal remodeling (fibrosis, epithelial basal zone hyperplasia, extracellular matrix deposition of fibronectin). "
5.	Hyperplasia 01/01/2014 - "Pharmacologic inhibition of AMCase with ip allosamidin inhibited both OVA induced increases in esophageal eosinophilic inflammation and OVA induced esophageal remodeling (fibrosis, epithelial basal zone hyperplasia, extracellular matrix deposition of fibronectin). "

Related Drugs and Biologics

1.	Caffeine (No Doz)
2.	Chitinase
3.	Dexamethasone (Maxidex)
4.	Chemokine CCL11
5.	Fibronectins (Fibronectin)
6.	Carrier Proteins (Binding Protein)