Oligosaccharides

Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.

Networked: 1372 relevant articles (36 outcomes, 133 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miyoshi, Eiji: 19 articles (05/2015 - 11/2003)
2.	Garssen, Johan: 13 articles (05/2015 - 08/2006)
3.	Lebrilla, Carlito B: 12 articles (12/2014 - 09/2004)
4.	Lityńska, Anna: 10 articles (08/2014 - 01/2002)
5.	Taniguchi, Naoyuki: 9 articles (01/2015 - 02/2002)
6.	An, Hyun Joo: 9 articles (03/2013 - 03/2005)
7.	Hopwood, John J: 8 articles (07/2010 - 01/2002)
8.	Fuller, Maria: 7 articles (01/2014 - 05/2004)
9.	Hoja-Łukowicz, Dorota: 7 articles (12/2013 - 01/2002)
10.	Meikle, Peter J: 7 articles (09/2006 - 01/2002)

Related Diseases

1.	Infection 12/01/2014 - "In this study, we develop a concept of rapid-throughput glycomics on human milk oligosaccharides, which have proven to be an important bioactive component of breast milk, providing the infant with protection against pathogenic infection and supporting the establishment of a healthy microbiota. " 10/01/2006 - "One year-long trial feeding both galacto-oligosaccharides and HN019 in children 1 to 3 years of age provided evidence for improved growth and reduction in infection incidence. " 06/01/2013 - "Study of the effect exerted by fructo-oligosaccharides from yacon (Smallanthus sonchifolius) root flour in an intestinal infection model with Salmonella Typhimurium." 04/01/2009 - "A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study." 01/01/2008 - "However, several strictly controlled rat infection studies showed that non-digestible fructo-oligosaccharides (FOS) increase, rather than decrease, translocation of Salmonella towards extra-intestinal sites. "
2.	Inflammation 04/01/2014 - "This study is aimed at exploring the therapeutic effects of long-term treatment with a combination of Bifidobacterium breve with non-digestible oligosaccharides on airway inflammation and remodeling. " 01/01/2015 - "Bifidobacteria grown on human milk oligosaccharides downregulate the expression of inflammation-related genes in Caco-2 cells." 10/10/2014 - "forskali fCS oligosaccharides were also tested in a mouse peritoneal inflammation model, where they caused a reduction in neutrophil infiltration. " 12/01/2012 - "Finally, it can be said that inflammation-induced small-sized oligosaccharides can have beneficial effects on epidermal regeneration and topically applied oligosaccharide of HA can have healing effects in skin problems." 05/01/2012 - "Milk oligosaccharides influence the composition of intestinal microbiota and thereby mucosal inflammation. "
3.	Flatulence 09/01/2015 - "This study was conducted to investigate the effect of open and controlled fermentation on the proximate composition, mineral elements, antinutritional factors and flatulence-causing oligosaccharides in Vigna racemosa. " 10/01/2015 - "lactis led to a significant decrease in flatulence causing oligosaccharides. " 01/01/2014 - "Soybeans and other pulses contain oligosaccharides which may cause intestinal disturbances such as flatulence. " 08/01/2001 - "The consumption of fructo oligosaccharides led to a small (6%; P < 0.02) increase in stool frequency in the pre-holiday period and gave a significantly better sense of 'well-being' during the holiday, although subjects reported more flatulence. " 12/01/1991 - "fermentum B-585 reduced the content of flatulence oligosaccharides. "
4.	Neoplasms (Cancer) 01/15/1997 - "However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. " 01/01/2008 - "NMR structural studies of oligosaccharides related to cancer processes." 01/01/2007 - "Oligosaccharides have been credited with many health-promoting functions, which had been identified in many clinical studies, such as promoting the growth of Bifidobacterium in human intestine and balance of intestinal bacteria, modulating the immune response, inhibition of cancer and tumor, stimulation of mineral absorption. " 05/21/2001 - "On the basis of studies using the Min mouse model of colon carcinogenesis, we have recently proposed that a fibre-like food (short-chain fructo-oligosaccharides, sc-FOS) fermented in the colon may stimulate a mechanism of cancer immunosurveillance. " 01/01/1988 - "The experiments described in this study examined cell membrane oligosaccharides, malignancy-related cell phenotypes and tumor cell susceptibility to the killing effect of human cytotoxic cells. "
5.	Colitis 07/01/2012 - "Supplementation with galacto-oligosaccharides increases the percentage of NK cells and reduces colitis severity in Smad3-deficient mice." 03/01/2006 - "Group OS received 500 mg/(kg.d) of goat milk oligosaccharides orally, starting 2 d before the colitis induction until d 6, and groups T and C received the vehicle. " 03/01/2006 - "Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. " 03/01/2006 - "Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis." 09/01/2002 - "The purpose of this study was to investigate the effects of galacto-oligosaccharides on the development of inflammation and on the growth of bifidobacteria in trinitrobenzene sulphonic acid (TNBS)-induced colitis, a model that has been shown to benefit from short-chain fatty acid administration and to be associated with alterations in the colonic microflora. "

Related Drugs and Biologics

1.	Prebiotics
2.	Antibodies
3.	Raffinose
4.	stachyose
5.	Mucins
6.	Hyaluronic Acid (Hyaluronan)
7.	Chitosan
8.	Polysaccharides
9.	pectin
10.	5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Intravenous Infusions
3.	Gastrectomy
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)