Hydrazines

08/01/1998 - "Human occupational data and studies in laboratory animals suggest that people exposed to hydrazines may develop adverse systemic health effects or cancer. "
01/01/1987 - "Many hydrazines tested in animal studies appear to be carcinogenic and induce tumors in various target tissues in mice, hamsters, and rats. "
01/01/1980 - "New findings from animal studies indicate that there is a serious cancer risk associated with exposures to hydrazines. "
08/24/1978 - "The work is part of a series of studies aimed at revealing the relative carcinogenic potency of mono- and dialkyl-hydrazines and also their possible environmental significance as cancer causative agents."
01/01/2022 - "Galloyl-substitution does not have a very strong synergistic effect in the inhibition of cancer cell proliferation compared with galloyl hydrazide (2). "

01/01/2011 - "Hydrazide drugs that inhibit growth and proliferation of tuberculosis bacteria."
01/01/1967 - "[Influence of thyroid gland hypofunction on the course of experimental tuberculosis with hydrazide-resistant bacilli]."
03/01/1965 - "[Clinico-statistical considerations on tubercular epidemiology in the province of Pesaro-Urbino in the pre-hydrazide period (1935-1962), limited to primary tuberculosis. "
09/01/1964 - "[CLINICO-STATISTICAL CONSIDERATIONS ON TUBERCULAR EPIDEMIOLOGY IN THE PESARO-URBINO PROVINCE, IN THE PRE-HYDRAZIDE PERIOD (1935-1952), LIMITED TO FIRST ASCERTAINED TUBERCULOSIS. "
07/01/1955 - "[Mechanism of chemotherapeutic action of PAS hydrazide in tuberculosis; in vitro effects on PAS-resistant tubercle bacillus]."

02/29/1960 - "[Note on the utilization of streptomyclidine isonicotinyl hydrazide (SH) in pulmonary tuberculosis]."
05/16/1957 - "Observations with cyanocetyl hydrazide PAS compound in pulmonary tuberculosis."
01/01/1955 - "[Treatment of pulmonary tuberculosis with the hydrazide of cyanoacetic (CEH)]."
07/01/1954 - "[Clinical report on several cases of pulmonary tuberculosis treated with PAS hydrazide]."
10/01/1953 - "[Erythrocyte resistance in pulmonary tuberculosis treated with isonicotinic hydrazide]."

01/01/2019 - "Further, in vivo studies were undertaken where rats were treated with 25, 50 and 100 mg/kg TG or standard MPO inhibiting drug4‑Aminobenzoic hydrazide (4‑ABH) at 60 min prior, post immediate and an hour post 90 min of middle cerebral artery occlusion (MCAo) followed by 24 h reperfusion. "
05/01/2007 - "We now report that the histidine analogue histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke when administered intravenously at a dose of 20 mg/kg, either 30 min before or 60 min and 3 h after the onset of middle cerebral artery occlusion. "

01/01/2023 - "The present study examined the newly synthesized compounds of aziridine-hydrazide hydrazone derivatives to determine their antineoplastic potential against glioblastoma cells in vitro. "
01/01/2023 - "Autophagy Inhibition with Chloroquine Increased Pro-Apoptotic Potential of New Aziridine-Hydrazide Hydrazone Derivatives against Glioblastoma Cells."
01/01/2023 - "The new aziridine-hydrazide hydrazone derivatives, which present cytotoxic potential against glioblastoma cells comparable to or even higher than that of temozolomide, show promising results and, thus, should be further investigated as antineoplastic agents. "