Chitin

A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.

Networked: 898 relevant articles (28 outcomes, 89 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ifuku, Shinsuke: 14 articles (05/2022 - 06/2012)
2.	Jayakumar, R: 14 articles (09/2019 - 02/2010)
3.	Azuma, Kazuo: 10 articles (12/2020 - 09/2012)
4.	Samuelson, John: 9 articles (01/2019 - 05/2006)
5.	Okamoto, Yoshiharu: 9 articles (01/2017 - 09/2012)
6.	Elias, Jack A: 8 articles (01/2018 - 06/2004)
7.	Osaki, Tomohiro: 8 articles (01/2017 - 09/2012)
8.	Shibuya, Naoto: 8 articles (11/2016 - 01/2010)
9.	Ye, Qifa: 7 articles (09/2022 - 06/2014)
10.	Zhang, Lina: 7 articles (08/2022 - 06/2014)

Related Diseases

1.	Infections 12/01/2023 - "In this study, the role of different planktonic substrates (phytoplankton cells, marine aggregates and chitin fragments) in mediating V. aestuarianus 02/041 infection of oysters was evaluated by controlled infection experiments. " 10/01/2019 - "Overall, this study is the first characterization of a LysM effector from Basidiomycota, suggesting that this necrotrophic fungal species relies on perturbation of chitin-triggered immunity to establish a successful infection." 01/01/2019 - "In this study, we focused on chitin metabolism related DEGs, and screened 10 genes involved in chitin synthesis and degradation with down-regulated trends, indicating that the chitin metabolism pathway was inhibited by ApNPV infection, which may promote liquefaction of A. " 11/21/2023 - "Comparison of the long-term and short-term protection in mouse model of Leishmania major infection following vaccination with Live Iranian Lizard Leishmania mixed with chitin microparticles." 08/29/2023 - "The expression pattern analysis revealed that tae-miR397 expression was higher in young leaves than in other tissues and was significantly decreased in wheat Bainong207 leaves after Blumeria graminis (Bgt) infection and chitin treatment. "
2.	Mycoses (Diseases, Fungus) 12/11/2019 - "Juxtamembrane phosphomimetic mutations of CERK1 confer accelerated chitin responses and fortified fungal resistance without triggering constitutive immunity, whereas juxtamembrane phosphodeficient mutations diminish bacteria-induced protection against fungal infection. " 06/01/2023 - "Our study suggests that chitin-mediated immunity plays a role in fruit, providing a possible way to reduce fungal infection-related fruit losses by enhancing the chitin-induced immune responses." 10/19/2021 - "Our previous studies showed that Arabidopsis Toxicos en Levadura 12 (ATL12) is highly induced in response to fungal infection and chitin treatment. " 08/01/1995 - "This method of chitin determination may be a useful alternative method for future investigations involving the study of fungal infections in mammalian tissues." 01/01/2023 - "Inhibition of chitin deacetylases to attenuate plant fungal diseases."
3.	Wounds and Injuries (Trauma) 01/01/2021 - "Notably, the regenerated chitin nonwoven fabrics with 71% DA significantly improved the wound healing compared to the commercial wound dressing Algoplaque film. " 12/12/2019 - "The article presents the results of clinical trials of wound dressings whose main ingredient is butyric-acetic chitin copolyester (BAC 90:10). " 12/12/2019 - "Characteristic Features of Wound Dressings Based on Butyric-Acetic Chitin Copolyesters-Results of Clinical Trials." 03/09/2012 - "The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. " 12/01/2008 - "The study shows the chitin dressings as useful adjunct in wound care."
4.	Neoplasms (Cancer) 05/20/2016 - "Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery." 10/01/2015 - "The present study is focused on the effect of chitin derivatives against human cancer cell lines RD and Hep2. " 01/01/2013 - "In this study, we explored if in vivo administration of chitin microparticles has an effect on the expression of CHI3L1 and pro-angiogenic molecules in the lungs of mammary tumor-bearing mice. " 07/17/2022 - "Furthermore, chitin can be used in cancer treatment as a vehicle for delivering cancer drugs to a specific site and has an antiproliferative effect by reducing the viability of cells. " 07/11/2022 - "A research gap in using chitin derivatives as anti/pro-inflammatory agents in cancer treatment has been highlighted."
5.	Hypersensitivity (Allergy) 10/01/2007 - "A recent intriguing study has highlighted the role of chitin in allergic reactions." 08/01/2015 - "Furthermore, cell wall integrity (CWI) was largely affected by deletion of SAC1, due to the hypersensitivity to cell wall stress, changed content and distribution of chitin in the mutant. " 04/02/2013 - "Thus, chitin induces the generation of C3a in the lung, and chitin-dependent allergic sensitization to Aspergillus requires C3aR signaling, which suppresses regulatory dendritic cells and T cells and induces allergy-promoting T cells." 07/15/2010 - "Overexpression of STE24 resulted in hypersensitivity to CFW and a slight increase in chitin levels. " 02/21/2010 - "Due to the fact that some individuals are allergic to crustaceans, the presumed relationship between allergy and the presence of chitin in crustaceans has been investigated. "

Related Drugs and Biologics

1.	Chitosan
2.	Glucans
3.	Polysaccharides (Glycans)
4.	Glucosamine (Dona)
5.	Solutions
6.	Carrier Proteins (Binding Protein)
7.	Cytokines
8.	Immunoglobulin E (IgE)
9.	beta-Glucans
10.	Phosphates (Orthophosphate)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Intranasal Administration
5.	Activities of Daily Living (ADL)