Hexosamines

01/01/2006 - "Hexosamines, insulin resistance, and the complications of diabetes: current status."
10/01/2004 - "Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue."
03/01/2001 - "Using rat-1 cells, we examine further the mechanisms whereby hexosamines lead to insulin resistance. "
08/01/1996 - "Hexosamines and insulin resistance."
01/01/2006 - "The formation of uridine 5 cent-diphosphate-hexosamines has been shown to be involved in abnormal E-C coupling and myocardial insulin resistance. "

03/01/1999 - "Hexosamines have been hypothesized to mediate aspects of glucose sensing and toxic effects of hyperglycemia. "
10/01/2004 - "It has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represents a biochemical mechanism by which hyperglycemia and hyperlipidemia induce insulin resistance. "
11/01/2002 - "In conclusion, after amelioration of hyperglycemia- induced insulin resistance, UDP-hexosamines increased in skeletal muscle of patients with type 2 DM. "
11/01/2002 - "Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 diabetes."
09/01/2000 - "Hexosamines have been shown to mediate effects of hyperglycemia and so-called "glucose toxicity" in insulin-sensitive tissues. "

12/01/1993 - "In the present study, we examined the presence of deacetylases capable of producing free hexosamines, which we have shown earlier to be immunosuppressive against human natural killer (NK) cell-mediated cytotoxicity, from N-acetylhexosamines in human tumor cells. "
12/01/1993 - "The ability to produce free hexosamines from N-acetylated aminosugars may provide a new mechanism for the escape of tumor cells from the attack of immune effector cells such as NK cells."
10/01/1992 - "We also discuss the tissue distribution of new F-18 labeled hexosamines, N-(F-18)-fluoroacetyl-D-mannosamine and N-(F-18)-fluoroacetyl-D-galactosamine in tumor bearing rats."
12/31/1983 - "They are not tumor specific, but seem to be related to the tumor burden; hexosamines seem to have some prognostic value."
12/31/1983 - "PASG and hexosamines significantly increased with cancer progression and decreased when objective response to treatment was achieved. "

01/01/1991 - "Gastric function was studied in 69 peptic ulcer patients in the long-term period after gastric resection according to Billroth-I and Billroth-II. Enzyme-producing function of the stomach was appraised according to the blood pepsinogen content, acid-forming function was assessed with the aid of intragastric pH-metry, and mucus-forming one in accordance with the content of hexosamines and sialic acids in gastric juice. "
07/01/2001 - "The results of the study made in 43 patients with gastroduodenal ulcer have shown an increase in the production of proinflammatory cytokines (interleukin-1 beta, the tumor necrosis factor-alpha) and a decrease in the blood serum content of the transforming growth factor-beta, which events come to favour degradation processes in collagen and fucoglycoproteins with a concomitant increase in free oxyproline, serum protein-unbound fucose against the background of a suppressed synthesis of the extracellular matrix carbohydrate-protein components as evidenced by the serum diminished concentrations of protein-bound oxyproline and fucose, hexuronic acids, and hexosamines."

03/01/1984 - "In this study the concentrations of the three major carbohydrates (sialic acid, galactose and hexosamines) of the erythrocyte membrane were therefore determined in patients with myotonic dystrophy, limb-girdle dystrophy and congenital myotonia. "