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KIRA8

An IRE1α kinase-inhibiting RNase attenuator.

Also Known As:

(S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Backes, Bradley J: 3 articles (01/2022 - 01/2019)
2.	Papa, Feroz R: 3 articles (01/2022 - 01/2019)
3.	Auyeung, Vincent C: 2 articles (01/2022 - 01/2019)
4.	Sheppard, Dean: 2 articles (01/2022 - 01/2019)
5.	Thamsen, Maike: 2 articles (01/2022 - 01/2019)
6.	Downey, Michael S: 1 article (01/2022)
7.	Wenger, Talia A: 1 article (01/2022)
8.	Hosoi, Hiroki: 1 article (08/2020)
9.	Ishibashi, Tatsuya: 1 article (08/2020)
10.	Kinoshita, Akira: 1 article (08/2020)

Related Diseases

1.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2022 - "IRE1α enhances the profibrotic phenotype of DATPs since KIRA8 decreases expression of integrin αvβ6, a key activator of transforming growth factor β (TGF-β) in pulmonary fibrosis, corresponding to decreased TGF-β-induced gene expression in the epithelium and decreased collagen accumulation around DATPs. "
2.	Neoplasms (Cancer) 08/31/2020 - "We characterized UPR phenotypes in the bone marrow of patients with newly diagnosed MM. Then, in human MM cells we analyzed the possible anti-tumor mechanisms of KIRA8 and a Food and Drug Administration (FDA)-approved drug, nilotinib, which we recently identified as having a strong inhibitory effect against IRE1α activity. " 08/31/2020 - "Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib."
3.	Multiple Myeloma 08/31/2020 - "Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib."
4.	Fibrosis (Cirrhosis) 01/01/2019 - "Finally, we show that KIRA8, a nanomolar-potent, monoselective KIRA compound derived from a completely different scaffold than KIRA7, likewise promoted reversal of established fibrosis. "
5.	Alcoholic Fatty Liver 12/03/2022 - "KIRA8 attenuates non-alcoholic steatohepatitis through inhibition of the IRE1α/XBP1 signalling pathway."

Related Drugs and Biologics

1.	Integrins
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Collagen
4.	STF 083010
5.	nilotinib