Integrins

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

Networked: 3019 relevant articles (40 outcomes, 325 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tang, Chih-Hsin: 18 articles (06/2014 - 01/2004)
2.	Goodman, Simon L: 13 articles (10/2015 - 06/2009)
3.	Ginsberg, Mark H: 12 articles (07/2015 - 08/2002)
4.	Chen, Xiaoyuan: 12 articles (01/2013 - 01/2004)
5.	Hynes, Richard O: 11 articles (02/2015 - 01/2002)
6.	Okada, Yuji: 11 articles (01/2008 - 01/2003)
7.	Funahashi, Hitoshi: 11 articles (01/2008 - 01/2003)
8.	Sawai, Hirozumi: 11 articles (01/2008 - 01/2003)
9.	Manabe, Tadao: 11 articles (01/2008 - 01/2003)
10.	Languino, Lucia R: 10 articles (02/2015 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2014 - "In vitro, NRP-1 interaction improved binding and internalization of the virus in different cancer cells overexpressing integrins and NRP-1. " 04/01/2008 - "Antiangiogenic peptide drugs have received much attention in the fields of tumor therapy and tumor imaging because they show promise in the targeting of integrins such as alpha(v)beta(3) on angiogenic endothelial cells. " 11/01/2015 - "Cell binding and blocking assays, autoradiographic evaluation of tissue binding and blocking, dynamic PET scans, and a biodistribution study were conducted using cell lines and murine tumor models with determined expression levels of α5β1 and other related integrins. " 06/01/2015 - "This review will attempt to overview the status of studies dealing with the involvement of integrins in the unique aggressive character of PDAC, the current status of experimental cancer therapies targeted at integrins, and the possible application of these preliminary clinical experiments to future PDAC therapy. " 03/01/2015 - "This study provides valuable new insight into the potential therapeutic benefit of NEDD9 depletion to reduce dissemination of tumor cells and discovers a new regulatory role of NEDD9 in promoting migration through modulation of CAV1-dependent trafficking of integrins."
2.	Glioma (Gliomas) 01/01/2011 - "Promising results in these trials would probably result in a broader interest in integrins as targets for glioma therapy and hopefully the development of a broader panel of anti-integrin agents." 07/01/2012 - "Our studies thus elucidate the potential role of hUCBSC in controlling glioma cell cycle progression and invasion by limiting Max binding to c-Myc, thus regulating the expression of glioma cell cycle and invasion associated molecules such as ERK, integrins via increased levels of Mad1 expression." 10/01/2011 - "In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. " 01/01/2014 - "Microarray results indicate that VE-statin/Egfl7 may regulate EGFR and integrins to influence the FAK activity of downstream factors, triggering the PI3K/Akt and Ras/MAPK cascades and subsequent malignant glioma development. " 01/01/2014 - "When integrins were inhibited in nonsphere glioma cells, the TGF-β pathway was strongly impaired, whereas no such effect was observed in glioma cells cultured under sphere conditions. "
3.	Infection 10/01/2014 - "The crawling within these capillaries was mediated by the β(2) and α(4) integrins and blocking these integrins 2 hours post infection eliminated neutrophil crawling, improved capillary perfusion, reduced cell death and reduced lesion size. " 08/01/2013 - "Our study was designed to clarify the involvement of integrins in WNV infection of cells. " 01/01/2009 - "Different integrins had been involved as FMDV receptors (alphavbeta1, alphavbeta3, alpha5beta1, alphavbeta6, alphavbeta8); this review will try to resume the basic information about FMDV receptors from the last years to the present and will resume the most important in vitro and in vivo studies to elucidate the role of this receptor on the infection." 12/01/2008 - "Together, these studies suggest that KSHV interacts with functionally related integrins (alphaVbeta3, alpha3beta1, and alphaVbeta5) and CD98/xCT molecules in a temporal fashion to form a multimolecular complex during the early stages of endothelial cell infection, probably mediating multiple roles in entry, signal transduction, and viral-gene expression." 03/01/2006 - "This study thus demonstrates that the presence of CMV in PMNLs, which characterizes active infection, modifies the expression of integrins and may thus affect cell-to-cell interactions and immune functions."
4.	Multiple Sclerosis 01/01/2013 - "Lymphocyte inhibition by antagonism of α4 integrins is a validated therapeutic approach for relapsing multiple sclerosis (RMS). " 06/01/1998 - "The expression of integrins on activated T-cells in multiple sclerosis. " 08/01/1993 - "Comparison between the different categories revealed that peripheral blood T cells from patients with multiple sclerosis expressed significantly lower amounts of the VLA integrins 4 and 5 as well as their common beta subunit CD29, compared with normal control subjects. " 03/15/2014 - "We examined the regulatory role of αv integrins in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model of multiple sclerosis (MS). " 01/01/2013 - "Expression of pericyte integrins within remodeling cerebral blood vessels was analyzed using dual immunofluorescence (IF) of brain sections derived from the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). "
5.	Prostatic Neoplasms (Prostate Cancer) 08/01/2005 - "The findings that beta1 integrins and IGF-IR are concurrently deregulated and that expression of beta1 integrins is necessary to achieve appropriate IGF-IR intracellular distribution point to the important role that the cross-talk between these receptors may have during prostate cancer progression and will be helpful in formulating new therapeutic strategies." 02/20/2015 - "In this study, we have investigated whether transfer of integrins through exosomes between prostate cancer (PrCa) cells occurs and whether transferred integrins promote cell adhesion and migration. " 01/01/2015 - "In this study, we report an active targeting liposomal formulation directed by a novel peptide (RGD) that specifically binds to the integrins receptors overexpressed on prostatic cancer cells. " 11/01/2011 - "Recent studies have shown that expression of αv integrins is elevated in the prostate cancer stem/progenitor cell subpopulation compared with more differentiated, committed precursors. " 08/01/2010 - "Our aim was to study the expression profile of integrins in surgical specimens of prostate cancer and associate their expression patterns with patient outcomes. "

Related Drugs and Biologics

1.	Ligands
2.	arginyl-glycyl-aspartic acid
3.	Collagen
4.	Peptides
5.	Fibronectins (Fibronectin)
6.	Cilengitide
7.	Antigens
8.	Integrin alphaVbeta3
9.	EMD 121974
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Immunotherapy
4.	Transplantation (Transplant Recipients)
5.	Heterologous Transplantation (Xenotransplantation)