Sulfones

07/01/2010 - "The therapeutic role of sulfones related to both pathogen-caused diseases and chronic inflammatory dermatoses has led to extensive use in dermatology. "
08/01/1963 - "DERMATITIS HERPETIFORMIS: A CHRONIC DERMATOSIS YIELDS TO SULFONES."
12/01/1980 - "Although the sulfones or sulfapyridine have been the mainstay of treatment, it is now clear that the skin disease responds to strict adherence to a gluten-free diet. "
11/01/2003 - "Dapsone belongs to sulfones group and is mainly recommended in skin diseases where gathering of neutrophiles or eosinophiles are found."
08/15/1986 - "These data suggest that a mechanism of action of sulfones in neutrophilic dermatoses may be a selective inhibition of neutrophil migration to as yet undefined chemoattractants in the skin."

07/01/2013 - "The improvement in living standards and the use of sulfones finally resulted in the control of leprosy. "
01/01/1955 - "[Importance of the study of sulfones in blood in sulfone therapy of leprosy]."
07/01/1950 - "Studies of the absorption, excretion, and distribution in the body of the sulfones used in the treatment of leprosy."
01/01/2015 - "In the case of leprosy, the discovery of sulfones in 1941 made a significant contribution towards transforming our understanding of this disease, leading to questions being raised as to the measures adopted for its prevention and control, particularly the compulsory isolation of sufferers. "
01/01/2011 - "Until the discovery of sulfones in the 1940s leprosy was largely incurable and it was expected that those who went to the island would never return. "

05/17/2004 - "Among the three propargylic sulfones 1a-c, carboxylic acid derivative 1c showed the most potent radiosensitizing activity toward hypoxic EMT6/KU tumor cells. "
07/01/1969 - "Cancer treatment with sulfones."
02/26/2009 - "Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells."
01/01/2012 - "An evaluation on different cancer cell lines reveals promising selective in vitro antiproliferative activity toward HepG2 human cell lines by dihydrogenated sulfones, suggesting further research should be to explore their anticancer potential in the treatment of liver cancer."
01/01/1984 - "Although dapsone has been implicated as a carcinogen in laboratory animals, the use of sulfones, including dapsone, did not appear to affect significantly the risk of any cancers in this population."

02/26/2009 - "Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells."
01/01/1973 - "Considerations on the use of sulfones and sulfamides with a pyrimidine derivative by the malaria control service of Mocambique."
01/01/1966 - "The need to investigate further the phenomenon of sulfone-induced haemolysis is becoming greater as the use of sulfones may increase, particularly for malaria therapy in areas where Plasmodium falciparum is found to be resistant to chloroquine. "
11/01/1971 - "Prophylaxis of malaria in man using the sulfones DFD and DDS alone and with chloroquine."
01/01/1970 - "The combined action of pyrimidines and sulfonamides or sulfones in the chemotherapy of malaria and other protozoal infections."

05/01/1998 - "Administration of sulfones was effective for reducing both skin and ocular inflammation. "