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Pediatric acute-onset neuropsychiatric syndrome

Also Known As:

PANS pediatric acute-onset neuropsychiatric syndrome

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Pediatric acute-onset neuropsychiatric syndrome: 14
Mental Disorders: 24177
- Anxiety Disorders: 7356
  - Obsessive-Compulsive Disorder: 4279
    - Pediatric acute-onset neuropsychiatric syndrome: 14

Related Diseases

1.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
2.	Streptococcal Infections (Streptococcal Infection)
3.	Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
4.	Postural Orthostatic Tachycardia Syndrome
5.	Autoimmune Diseases of the Nervous System

Experts

1.	Frankovich, Jennifer: 3 articles (01/2022 - 09/2017)
2.	Thienemann, Margo: 3 articles (01/2022 - 09/2017)
3.	Chan, Avis: 2 articles (01/2022 - 01/2021)
4.	Farhadian, Bahare: 2 articles (01/2022 - 09/2017)
5.	Melamed, Isaac: 2 articles (01/2021 - 01/2020)
6.	Lewin, Adam B: 2 articles (09/2017 - 05/2015)
7.	Murphy, Tanya K: 2 articles (09/2017 - 05/2015)
8.	Storch, Eric A: 2 articles (09/2017 - 05/2015)
9.	Gao, Jaynelle: 1 article (01/2022)
10.	Houston, Madison: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pediatric acute-onset neuropsychiatric syndrome:

1.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/2015 - "A pilot trial of cognitive-behavioral therapy augmentation of antibiotic treatment in youth with pediatric acute-onset neuropsychiatric syndrome-related obsessive-compulsive disorder." 05/03/2018 - "Antibiotics have been used extensively by clinicians to treat patients with PANDAS or PANS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and pediatric acute-onset neuropsychiatric syndrome, respectively). " 01/01/2021 - "Objective: The clinical characteristics of patients with PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) and PANS (pediatric acute-onset neuropsychiatric syndrome) and the efficacy of antibiotic therapy with psychotherapy and antipsychotics were investigated to improve neurological symptoms as well as obsessive compulsive disorder (OCD). "
2.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2021 - "Objective: The clinical characteristics of patients with PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) and PANS (pediatric acute-onset neuropsychiatric syndrome) and the efficacy of antibiotic therapy with psychotherapy and antipsychotics were investigated to improve neurological symptoms as well as obsessive compulsive disorder (OCD). "
3.	Intravenous Immunoglobulins (IVIG)FDA Link 01/01/2023 - "Intravenous immunoglobulin treatment improves multiple neuropsychiatric outcomes in patients with pediatric acute-onset neuropsychiatric syndrome." 01/01/2021 - "Evaluation of Intravenous Immunoglobulin in Pediatric Acute-Onset Neuropsychiatric Syndrome."
4.	Azithromycin (Zithromax)FDA LinkGeneric 09/01/2017 - "We assessed the preliminary efficacy, tolerability, and safety of azithromycin compared with placebo in the treatment of OCD and associated symptoms in children with pediatric acute-onset neuropsychiatric syndrome (PANS). "
5.	VaccinesIBA 01/01/2023 - "Objective: To examine symptom flares after COVID-19 infection and vaccines in the case of a form of autoimmune encephalitis that primarily affects children and young adults (pediatric acute-onset neuropsychiatric syndrome [PANS] / pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections [PANDAS]). "
6.	TabletsIBA 05/01/2023 - "A novel tablet-based motor coordination test performs on par with the Beery VMI subtest and offers superior temporal metrics: findings from children with pediatric acute-onset neuropsychiatric syndrome."
7.	Cysteine (L-Cysteine)FDA Link 01/01/2018 - "N-Acetyl Cysteine and Curcumin in Pediatric Acute-Onset Neuropsychiatric Syndrome."
8.	CurcuminIBA 01/01/2018 - "N-Acetyl Cysteine and Curcumin in Pediatric Acute-Onset Neuropsychiatric Syndrome."
9.	AutoantibodiesIBA 01/01/2020 - "This retrospective study examined whether changes in patient pre- and post-treatment symptoms correlated with changes in anti-neuronal autoantibody titers and the neuronal cell stimulation assay in the Cunningham Panel in patients with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS), and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). "
10.	AntibodiesIBA 01/01/2018 - "Work-up for underlying infectious, immunodeficiency, and autoimmune causes was unrevealing except for very high levels of anti-neuronal antibodies which have been linked to Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). "

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "Objective: The clinical characteristics of patients with PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) and PANS (pediatric acute-onset neuropsychiatric syndrome) and the efficacy of antibiotic therapy with psychotherapy and antipsychotics were investigated to improve neurological symptoms as well as obsessive compulsive disorder (OCD). "
2.	Immunomodulation 09/01/2017 - "Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II-Use of Immunomodulatory Therapies." 01/01/2022 - "We observed postural orthostatic tachycardia syndrome (POTS) which resolved with immunomodulation in a patient with Pediatric acute-onset neuropsychiatric syndrome (PANS). "