Immunomodulation

Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances.

Also Known As:

Networked: 2883 relevant articles (164 outcomes, 305 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Foster, C Stephen: 22 articles (12/2015 - 02/2002)
2.	Lu, Mengji: 9 articles (11/2015 - 05/2005)
3.	Shoenfeld, Yehuda: 9 articles (01/2015 - 02/2002)
4.	Shoenfeld, Y: 8 articles (12/2015 - 01/2000)
5.	Askenasy, Nadir: 7 articles (01/2014 - 09/2009)
6.	Roggendorf, Michael: 6 articles (11/2015 - 02/2006)
7.	Hartung, Hans-Peter: 6 articles (04/2014 - 03/2003)
8.	Aukrust, Pål: 5 articles (12/2015 - 07/2005)
9.	Vernino, Steven: 5 articles (07/2015 - 04/2007)
10.	Wisniewski, Thomas: 5 articles (01/2013 - 02/2009)

Related Diseases

1.	Infection 09/01/2010 - "Bloodstream infections should be reassessed periodically because of increased antibiotic resistance, more patients receiving immunomodulatory therapy, improved antiretroviral therapy, and acquisition of infection in health care settings other than hospitals. " 01/01/2005 - "The main objective of this study was to determine whether a chemical immunomodulation protocol could reduce the resistance of NOD/LtSz-SCID mice to Plasmodium falciparum infection and provide an improved mouse model for screening the antimalarial activity of new compounds. " 05/01/2015 - "Because the immune and inflammatory response to Leishmania (Viannia) species defines the outcome of infection and efficacy of treatment, immunomodulation is considered a promising therapeutic strategy. " 06/01/2006 - "Immunomodulation in the intestine and systemic sites has been suggested to mediate the protective effects of oral bLF against infection. " 08/01/2014 - "Thus, lymphocyte-derived cytokine production assays are helpful in the diagnostic workup of patients with recurrent infections and suspected immunodeficiencies and have the potential to reveal immune defects that might guide adjunctive immunomodulatory therapy. "
2.	Neoplasms (Cancer) 01/01/1997 - "The clinical results compared to conventional chemotherapy are summarized in Table 1. Several approaches are targeted at improved elimination of malignant cells: 1) incorporation of new drugs into preparative conditioning regimens, 2) tandem or multiple cycles of high-dose chemotherapy followed by stem cell rescue, 3) post-transplant immunomodulation aimed at inducing an antitumor effect, and 4) purging techniques to eliminate contaminating tumor cells from the transplant. " 10/15/2005 - "The authors found that the study of major histocompatability complex alleles holds promise for understanding the events that initiate and maintain tumor immunomodulation." 09/01/2014 - "Novel optimized aAPCs, combining carefully tuned properties, may lead to efficient immunomodulation and improved clinical responses in cancer immunotherapy. " 11/01/1998 - "Continued exploration of the pharmacologic methods to circumvent drug resistance, as well as strategies that involve targeted therapy and immunomodulation, should increase the specificity and efficacy of treatments for patients with cancer." 01/01/2014 - "In conclusion, this study demonstrated that APS could improve proliferation and function of intestinal intraepithelial γδT cells, which might an important pathway for immunomodulation of APS in cancer therapy. "
3.	Inflammation 07/15/2006 - "Overall, the common signature genes provide a molecular basis for a number of documented or suggested properties of M2, including immunomodulation, down-regulation of inflammation, protection against oxidative damage, high capacity for phagocytosis, and tissue repair. " 11/01/2015 - "Immunomodulation of Airway Epithelium Cell Activation by Mesenchymal Stromal Cells Ameliorates House Dust Mite-Induced Airway Inflammation in Mice." 04/01/2014 - "The Ozurdex implant in combination with systemic immunomodulatory therapy resulted in improved visual acuity, control of intraocular inflammation, and a decrease in corticosteroid use. " 12/28/2015 - "This study suggests that NP surface chemistry may regulate the immune response, which provides a new paradigm for potential applications of NPs in anti-inflammation and immunomodulation. " 08/15/2015 - "In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs."
4.	Multiple Sclerosis 11/01/2009 - "Owing to a number of promising results obtained in mouse models of multiple sclerosis, cell therapies implementing hematopoietic, mesenchymal and neural stem cells may provide practical vehicles for in situ immunomodulation, neuroprotection and regeneration. " 04/01/2009 - "The efficacy of many new immunomodulatory therapies for multiple sclerosis (MS) patients has often been disappointing, reflecting our incomplete understanding of this enigmatic disease. " 05/29/2007 - "Based on the efficacy of immunomodulatory therapies in patients with multiple sclerosis (MS), much of the research and thinking about pathogenesis and treatment has traditionally focused on suppressing the immune system. " 04/17/2007 - "MRI has revolutionized the diagnostic accuracy of multiple sclerosis (MS) in adults, and is now used extensively to evaluate efficacy of immunomodulatory therapies. " 04/14/2007 - "[Still no evidence on the efficacy of immunomodulatory therapy in reducing functional impairment in multiple sclerosis]."
5.	Uveitis 11/01/2014 - "Immunomodulatory therapy that also acts as a corticosteroid sparing therapy can be effective in controlling chronic uveitis in patients with spondyloarthropathy." 12/01/2007 - "Therefore, further studies are warranted in order to reveal whether administration of early immunomodulatory therapy can delay or even prevent the clinical manifestation of MS in a distinct subgroup of patients presenting with uveitis." 01/01/2016 - "Immunomodulatory Therapy in Uveitis." 09/01/2013 - "Immunomodulatory therapy has been associated with better outcomes in noninfectious pediatric uveitis. " 03/01/2012 - "A survey was distributed to the American Uveitis Society and Proctor email listservs in order to restrict the respondents to specialists who likely have extensive experience in the use of immunomodulatory therapy. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Intravenous Immunoglobulins (IVIG)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Cytokines
5.	Antigens
6.	Immunoglobulins (Immunoglobulin)
7.	copolymer 1 (glatiramer acetate)
8.	infliximab (Remicade)
9.	Steroids
10.	Interferon-beta

Related Therapies and Procedures

1.	Photopheresis
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Stem Cell Transplantation