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Intravenous Immunoglobulins (IVIG)

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Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Also Known As:

IVIG; Immunoglobulins, Intravenous; Alphaglobin; Endobulin; Gamimmune; Gamimmune N; Gamimune; Gamimune N; Gammagard; Gammonativ; Globulin-N; IV Immunoglobulins; Immune Globulin, Intravenous; Intraglobin; Intraglobin F; Intravenous IG; Iveegam; Modified Immune Globulin (Anti-Echovirus Antibody); Sandoglobulin; Venimmune; Venoglobulin; Venoglobulin-I; Globulin N; GlobulinN; Immunoglobulins, IV; Intravenous Immune Globulin; Venoglobulin I; VenoglobulinI; Antibodies, Intravenous; Intravenous Antibodies

Networked: 3697 relevant articles (685 outcomes, 704 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Blood Proteins: 4303
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Intravenous Immunoglobulins: 3697
        respiratory syncytial virus immune globulin intravenous: 20
        HIV hyperimmune globulin: 19
        Gamunex: 16
        Veronate: 7
        Octagam: 6
        Privigen: 3
        OMRI-Hep-B: 1
    - Immunoproteins: 33
      - Immunoglobulins: 23980
        Antibodies: 92632
        Intravenous Immunoglobulins: 3697
        respiratory syncytial virus immune globulin intravenous: 20
        HIV hyperimmune globulin: 19
        Gamunex: 16
        Veronate: 7
        Octagam: 6
        Privigen: 3
        OMRI-Hep-B: 1
        Immunoglobulin Isotypes: 356
        Immunoglobulin G: 38635
        Intravenous Immunoglobulins: 3697
        respiratory syncytial virus immune globulin intravenous: 20
        HIV hyperimmune globulin: 19
        Gamunex: 16
        Veronate: 7
        Octagam: 6
        Privigen: 3
        OMRI-Hep-B: 1
  - Globulins: 334
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Intravenous Immunoglobulins: 3697
        respiratory syncytial virus immune globulin intravenous: 20
        HIV hyperimmune globulin: 19
        Gamunex: 16
        Veronate: 7
        Octagam: 6
        Privigen: 3
        OMRI-Hep-B: 1

Experts

1.	Shoenfeld, Yehuda: 44 articles (03/2015 - 04/2002)
2.	Shoenfeld, Y: 26 articles (12/2015 - 01/2000)
3.	Dalakas, Marinos C: 24 articles (02/2015 - 12/2002)
4.	Kaveri, Srini V: 20 articles (07/2015 - 01/2003)
5.	Bayry, Jagadeesh: 18 articles (07/2015 - 01/2003)
6.	Lazarus, Alan H: 18 articles (06/2015 - 05/2003)
7.	Burns, Jane C: 17 articles (05/2015 - 02/2003)
8.	Bazin, Renée: 15 articles (02/2014 - 10/2004)
9.	Nimmerjahn, Falk: 14 articles (10/2015 - 01/2007)
10.	Crow, Andrew R: 13 articles (06/2015 - 05/2003)

Related Diseases

1.	Infection 10/01/1998 - "Most studies demonstrate beneficial results of IVIG treatment, especially on frequency and severity of infections in patients with advanced HIV disease. " 01/01/2004 - "Treatment with IVIG (seven trials, n = 262) in cases of subsequently proven infection did result in a statistically significant reduction in mortality [typical RR 0.55 (95% CI; 0.31, 0.98)In spite of different geographical locations of the studies, differences in the mortality in the control groups (range 0% - 43.8%), the use of different IVIG preparations, and different dosing regimens, there was no statistically significant between-study heterogeneity for the outcome of mortality in the two analyses. " 01/01/2014 - "In patients with active disease and concomitant infections, the response to IVIG treatment was a complete remission (n=9), partial remission (n=8), and no response (n=8). " 01/01/2002 - "The intravenous immunoglobulins has been proven beneficial in prophylaxis and treatment of infections in patients with primary and secondary immunodeficiency. " 06/01/1987 - "IVIG (0.025 g/kg) administered topically by the intranasal route to anesthetized cotton rats at the height of RSV infection effected a 10(2.2)-fold reduction in viral titers of pulmonary tissues and a complete clearance of detectable virus in 92% of the animals within 24 h. "
2.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 08/01/1996 - "Of the 30 patients, 19 (63%) improved with IvIg treatments; nine out of 16 patients (56%) with chronic progressive CIDP, and 10 out of 14 patients (71%) with relapsing CIDP (differences were not statistically significant). " 06/01/1991 - "High-dose IVIG was a safe and effective adjunctive therapy for childhood CIDP in these four patients." 07/01/2015 - "This difference may help to balance the more frequent response to IVIg than to IVMP in patients with CIDP." 05/01/2013 - "SCIG treatment in CIDP is feasible, safe and effective, and seems an attractive alternative to IVIG." 07/01/2008 - "On the basis of available data, IVIg can be recommended as a first-line treatment option for GBS and CIDP. "
3.	Autoimmune Diseases (Autoimmune Disease) 12/01/2014 - "Data from meta-analyses of heterogeneous placebo-controlled trials indicate that IVIg may be effective in secondary RM, but most trials to date have used immunomodulatory doses lower than those considered to be efficient in autoimmune disease. " 06/01/2005 - "The efficacy of IVIG has been established only in several autoimmune diseases; clinical reports of trials, series, and case reports indicate significant improvement in many more autoimmune diseases. " 12/01/1993 - "Results from the present study suggest a novel mechanism by which IVIg may be beneficial in human autoimmune diseases." 11/01/1994 - "The effect was evaluated of intravenous gammaglobulin (IVIg), a successful therapy in various autoimmune diseases, in relapsing-remitting MS patients treated for three years. " 03/01/1990 - "These results support the concept that IVIg may be beneficial in selected autoimmune diseases by modulating the function of the idiotypic network."
4.	Thrombocytopenia (Thrombopenia) 03/01/1998 - "The thrombocytopenia improved dramatically after IVIG therapy. " 10/01/2007 - "The therapeutic efficacy of IVIg in antibody-mediated thrombocytopenia was significantly reduced in presence of LPS. " 06/01/2015 - "Anti-CD44 is ineffective at inhibiting thrombocytopenia in B6;129S FcγRIIb-deficient mice but, like IVIG, is effective in splenectomized mice and FcγRIIb-deficient mice on the BALB/C and C57BL/6 background. " 05/01/2005 - "IVIg was first demonstrated to be effective in autoimmune disorders, two decades ago, in the treatment of acute immune thrombocytopenia. " 11/01/2002 - "The authors conclude that IVIG in the dose of 1 g/kg for 1-2 days is an effective treatment for NLE with severe thrombocytopenia especially when corticosteroid is contraindicated."
5.	Dermatomyositis (Dermatopolymyositis) 11/01/1995 - "We describe a group of patients with dermatomyositis, resistant to available therapies, whose muscle strength, skin changes, and muscle biopsies improved significantly during treatment with intravenous immune globulin. " 12/30/1993 - "High-dose intravenous immune globulin is a safe and effective treatment for refractory dermatomyositis." 01/01/2000 - "IVIG is effective in selected dermatomyositis patients. " 05/01/1996 - "In a double-blind, placebo-controlled study, using objective criteria for improvement, IVIG demonstrated moderate to dramatic improvement in 75% of the patients with dermatomyositis. " 09/01/2014 - "Clinical efficacy of intravenous immunoglobulins for the treatment of dermatomyositis skin lesions without muscle disease."

Related Drugs and Biologics

1.	Immunoglobulins (Immunoglobulin)
2.	Intravenous Immunoglobulins (IVIG)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Immunoglobulin G (IgG)
5.	Inosine Triphosphate (ITP)
6.	Steroids
7.	Antibodies
8.	Autoantibodies
9.	Methylprednisolone
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Plasma Exchange
2.	Plasmapheresis
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Immunotherapy