Abstract |
Methods: Results:
Actinin alpha 4 gene promoter was hypermethylated in the high glucose-treated groups. EGCG reversed the hypermethylated status of ACTN4, along with the upregulation of ACTN4 levels and downregulation of DNA methyltransferase 1 (DNMT1), NF-κB p65, p-NF-κB p65, IκB-α, VEGF, IL-8, α-SMA, and FN levels (P<.05). Conclusion:
Epigallocatechin-3-gallate reduced hypermethylation of ACTN4 in HPC cells by downregulating DNMT1 expression and restoring ACTN4 expression, contributing to the upregulation of the NF-KB p65, p- NF-KB p65, IKB-α, VEGF, IL-8, α-SMA, and FN levels (P<.05).
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Authors | Chunling He, Dong Wang, Ruoling Wang, Yongli Huang, Xin Huang, ShuMin Shen, Jun Lv, Mingcai Wu |
Journal | Dose-response : a publication of International Hormesis Society
(Dose Response)
2022 Apr-Jun
Vol. 20
Issue 2
Pg. 15593258221105704
ISSN: 1559-3258 [Print] United States |
PMID | 35706474
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2022. |