Abstract | Background: Methods: This was a cross-sectional study of 206 AD patients recruited from six hospitals in China. Thiamine diphosphate (TDP), the bioactive form of thiamine, was measured by high-performance liquid chromatography fluoroscopy (HPLC) at a single center. Levels of biochemical indicators (except TDP) were measured by regular and standard laboratory tests in each hospital. Pearson's rank correlation analysis was used to assess relationships between B vitamins and biochemical indicators. T-test was used to compare the difference between ApoE ε4 and non- ApoE ε4 groups. Differences were considered statistically significant as P < 0.05. Results: Conclusion: Our results indicated that TDP reduction could be a modifiable risk factor for malnutrition and FT3 that contributed to cognitive decline in AD patients. Correcting thiamine metabolism could serve as an optional therapy target for AD treatment.
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Authors | Ting Qian, Lei Zhao, Xiaoli Pan, Shaoming Sang, Yangqi Xu, Changpeng Wang, Chunjiu Zhong, Guoqiang Fei, Xiaoqin Cheng |
Journal | Frontiers in nutrition
(Front Nutr)
Vol. 9
Pg. 823573
( 2022)
ISSN: 2296-861X [Print] Switzerland |
PMID | 35265656
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Qian, Zhao, Pan, Sang, Xu, Wang, Zhong, Fei and Cheng. |