Vitamin B 12 (Cyanocobalamin)

A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.

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Networked: 4908 relevant articles (166 outcomes, 599 trials/studies)

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Drug Context: Research Results

Experts

1.	Refsum, Helga: 24 articles (01/2015 - 06/2003)
2.	Andrès, Emmanuel: 18 articles (03/2015 - 03/2003)
3.	Selhub, Jacob: 17 articles (01/2015 - 07/2002)
4.	Ueland, Per Magne: 17 articles (01/2015 - 06/2003)
5.	Nexo, Ebba: 16 articles (01/2014 - 11/2003)
6.	Herrmann, Wolfgang: 16 articles (01/2013 - 01/2002)
7.	Guéant, Jean-Louis: 14 articles (12/2014 - 11/2002)
8.	Ueland, Per M: 14 articles (03/2014 - 01/2004)
9.	Steiner, Jörg M: 13 articles (03/2015 - 08/2007)
10.	Clarke, Robert: 12 articles (09/2015 - 07/2003)

Related Diseases

1.	Anemia 01/01/1951 - "[Successful therapy of nutritional tropical anemia with vitamin B12]." 03/01/2012 - "The anemia rapidly improved with vitamin B12 treatment. " 03/01/2002 - "We investigated the efficacy of oral vitamin B12 (B12) therapy in patients with B12-deficiency anemia. " 02/01/2001 - "Her anemia improved after vitamin B12 therapy. " 07/01/1957 - "[7-Year remission of perniclous anemia proved by radioactive vitamin B12 test]."
2.	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 09/01/2014 - "Oral vitamin B12 treatment is effective for children with nutritional vitamin B12 deficiency." 10/01/2010 - "Is oral vitamin B(12) therapy effective for vitamin B(12) deficiency in patients with prior ileocystoplasty?" 10/01/2000 - "Vitamin B12 deficiency is effectively treated with oral vitamin B12 supplementation. " 11/01/2013 - "Intramuscular vitamin B12 continues to be the gold standard of therapy for vitamin B12 deficiency, especially in symptomatic patients. " 01/01/2012 - "Testing the total concentration of vitamin B12 alone has insufficient diagnostic accuracy and no accepted gold standard is available for diagnosing vitamin B12 deficiency. "
3.	Pernicious Anemia 01/01/2005 - "It has been suggested that high-dose (>2000 μg/d) oral cyanocobalamin may be effective in patients with pernicious anemia. " 09/01/1998 - "High dose oral cobalamin therapy was shown to be effective for pernicious anemia and other cobalamin deficiency states 30 years ago, and physicians and patients state that they would find oral therapy useful, but a survey conducted in 1989 found that physicians were generally unaware of it. " 11/01/1949 - "Vitamin B12 effective in pernicious anemia with combined system disease and liver sensitivity." 01/01/1983 - "[Case of pernicious anemia with immunodeficiency, improved after administration of vitamin B12]." 01/01/2015 - "In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). "
4.	Stroke (Strokes) 01/01/2013 - "In conclusion progression of pWML after 2 years of follow-up relates to low levels of vitamin B12 at baseline in first-ever lacunar stroke patients. " 01/01/2013 - "In 107 first-ever lacunar stroke patients in whom baseline brain MRI and vitamin B12 status were available, we obtained a follow-up brain MRI after 2 years. " 01/01/2013 - "We studied baseline vitamin B12 levels and its association with progression of WML over 2 years of follow-up in first-ever lacunar stroke patients. " 03/01/2010 - "In patients with Glasgow coma scale < or =8 (either hemorrhagic or ischemic stroke), a significant direct correlation was found between Glasgow coma scale and blood vitamin B12 levels. " 05/01/2009 - "More severe periventricular white matter lesions in lacunar stroke patients relate to lower vitamin B12 levels. "
5.	Dementia (Dementias) 05/01/2008 - "We administered vitamin B12, which improved the blood test results and the signs of dementia. " 01/01/2003 - "Evidence of any efficacy of vitamin B12 in improving the cognitive function of people with dementia and low serum B12 levels is insufficient. " 04/01/2012 - "A systematic literature search identified 43 studies investigating the association of vitamin B12 and cognitive impairment or dementia. " 12/01/2011 - "Data from human and animal studies indicate that cobalamin deficiency impairs neuronal function; a process that is thought to contribute to age-related cognitive decline and dementia. " 01/01/2003 - "From the two included studies (Seal 2002; Fourniere 1997) of people with dementia and low serum vitamin B12 levels, there was no statistically significant evidence of treatment effect, vitamin B12 supplementation compared with placebo, on cognitive function. "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Vitamin B 12 (Cyanocobalamin)
3.	Homocysteine
4.	Vitamins
5.	Vitamin B 6
6.	Iron
7.	Pyridoxine (Pyridoxin)
8.	Zinc
9.	Ascorbic Acid (Vitamin C)
10.	Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Activities of Daily Living (ADL)
5.	Intramuscular Injections