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Thiamine Pyrophosphate

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The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.

Also Known As:

Berolase; Pyrophosphate, Thiamine; Cocarboxylase; Thiamine Diphosphate; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, P,P'-dioxide

Networked: 269 relevant articles (7 outcomes, 16 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Suleyman, Halis: 4 articles (01/2014 - 12/2012)
2.	Cetin, Nihal: 4 articles (10/2013 - 12/2012)
3.	Akcay, Fatih: 3 articles (01/2014 - 12/2012)
4.	Altuner, Durdu: 3 articles (09/2013 - 12/2012)
5.	Demiryilmaz, Ismail: 3 articles (09/2013 - 12/2012)
6.	Turan, Mehmet Ibrahim: 2 articles (07/2014 - 01/2014)
7.	Borekci, Bunyamin: 2 articles (01/2014 - 10/2013)
8.	Sener, Ebru: 2 articles (09/2013 - 12/2012)
9.	Pala, Maria Immacolata: 2 articles (08/2013 - 01/2013)
10.	Costantini, Antonio: 2 articles (08/2013 - 01/2013)

Related Diseases

1.	Hepatitis 07/01/1989 - "[Thiamine diphosphate pool and its biosynthesis in the liver in galactosamine hepatitis]." 02/01/1966 - "[Acute atrophy of the liver due to viral hepatitis treated by coenzyme A, alpha-lipoic acid, D.P.N and cocarboxylase]." 04/01/1969 - "[Influence of coenzyme A, nicotinamide adenine dinucleotide (NAD), alpha-lipoic acid and cocarboxylase on acute hepatitis (double blind experiment)]." 08/15/1985 - "In the present study the efficacy of two different cofactor regimens (coenzyme A, NAD, alpha lipoic-acid, cocarboxylase) in rats with fulminant galactosamine hepatitis were tested. " 08/15/1985 - "Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis."
2.	Diabetes Mellitus 02/01/1979 - "[Effect of cocarboxylase on the coagulogram indices in diabetes mellitus]." 06/01/1972 - "[Use of cocarboxylase in steroid diabetes mellitus]." 07/01/1963 - "[EFFECT OF THIAMINE DIPHOSPHATE ON LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS]." 02/01/1960 - "[Combined therapeutic action of cocarboxylase with B-Z 55, and D-860 in diabetes mellitus]." 12/05/1953 - "[Cocarboxylase in the treatment of diabetes mellitus]."
3.	Cardiac Arrhythmias (Arrythmia) 10/01/1954 - "[Very grave myocardosis with complex arrhythmia and bronchopulmonitis in a diabetic woman and a case of degenerative encephalopathy in a diabetic alcoholic treated successfully with cocarboxylase]." 08/01/1968 - "[The coenzyme cocarboxylase in the treatment of cardiac arrhythmia in children]." 10/01/1967 - "[The use of cocarboxylase coenzyme in heart arrhythmia in children]." 11/01/1969 - "[Elimination of digitalis-induced arrhythmia with concurrent antagonists of aldosterone and cocarboxylase]."
4.	Polyneuropathies (Polyneuropathy) 01/01/1995 - "In patients with polyneuropathy high doses of thiamine pyrophosphate (Cocarboxylase), given i.v., can be helpful in this respect. " 01/01/1995 - "The blood thiamine content was low and the thiamine pyrophosphate (TPP) effect increased to more than 25 percent during the development of the beriberi polyneuropathy, which resumed after one week on thiamine tetrahydrofurfuryl disulfide (TTFD) treatment. "
5.	Diabetic Foot 05/01/2014 - "[Efficacy of thiamine pyrophosphate or carboxylase in the salvage of diabetic foot]." 05/01/2014 - "Given the clinical data and evolution of the patients, we conclude that the administration of thiamine pyrophosphate was able to control metabolic and non-metabolic dysfunctions that lead to complications in diabetic patients, therefore we must consider it a tool in the treatment of diabetic patients in general and for diabetic foot salvage in particular." 05/01/2014 - "Thiamine pyrophosphate or carboxylase perform multiple metabolic and non-metabolic activities that are considered important in the resolution of diabetic impairments, therefore, this work shows the results when using it in patients with diabetic foot. " 05/01/2014 - "29 patients with diabetic foot were treated between January 1998 and July 2012: 19 Wagner type III and 12 Wagner type IV. Management was the administration of antibiotics, partial surgical procedures and thiamine pyrophosphate. "

Related Drugs and Biologics

1.	Thiamine (Aneurin)
2.	Thiamine Pyrophosphate
3.	Thioctic Acid (Lipoic Acid)
4.	Coenzyme A (CoA)
5.	NAD (NADH)
6.	Galactosamine
7.	Insulin (Novolin)
8.	Cytochromes c (Cytochrome c)
9.	Flavin Mononucleotide (FMN)
10.	thiamine pyrophosphate drug combination flavin mononucleotide cytochrome C

Related Therapies and Procedures

1.	Intravenous Injections
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Radiotherapy
5.	Ovariectomy (Oophorectomy)