Triiodothyronine (Liothyronine)

A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

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Networked: 2454 relevant articles (52 outcomes, 176 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Marte, Filippo: 16 articles (04/2012 - 02/2009)
2.	Patanè, Salvatore: 16 articles (04/2012 - 02/2009)
3.	Iervasi, Giorgio: 14 articles (11/2014 - 11/2004)
4.	Pingitore, Alessandro: 8 articles (08/2013 - 02/2005)
5.	Botella-Carretero, José I: 7 articles (01/2015 - 06/2004)
6.	Escobar-Morreale, Héctor F: 7 articles (01/2015 - 06/2004)
7.	Danzi, Sara: 6 articles (07/2012 - 06/2002)
8.	Klein, Irwin: 6 articles (07/2012 - 06/2002)
9.	Nygaard, Birte: 5 articles (01/2015 - 01/2008)
10.	Nogueira, Célia Regina: 5 articles (08/2014 - 10/2009)

Related Diseases

1.	Hyperthyroidism 01/01/1956 - "Response to triiodothyronine as index of persistence of disease in the thyroid remnant of patients in remission from hyperthyroidism." 01/01/2013 - "A comparative genotoxicity study of a supraphysiological dose of triiodothyronine (T₃) in obese rats subjected to either calorie-restricted diet or hyperthyroidism." 06/01/1984 - "In this study, hypo- and hyperthyroidism were induced by 6-n-propyl-2-thiouracil (PTU) and triiodothyronine (T3) respectively. " 10/15/2013 - "Subclinical hyperthyroidism is defined as a low TSH with both FT4 and free triiodothyronine (FT3) concentrations within range (2.6-5.7 pmol/l). " 02/15/2013 - "Hyperthyroidism was induced by administration of triiodothyronine (T3; 300μg/kg, i.p., for 12 weeks in T3 group). "
2.	Graves Disease (Basedow Disease) 06/01/1965 - "[Test of inhibition of thyroid uptake of radioiodine by means of triiodothyronine in patients with Basedow's disease in clinical remission]." 06/01/1996 - "Prospective, randomized trial of patients with Graves' disease followed for 3 months after the initiation of therapy with an antithyroid drug and combined with the later addition of triiodothyronine to keep the patient euthyroid. " 01/01/1978 - "[Critical study of the value of serum triiodothyronine (T3) determination in Basedow's disease]." 06/01/2015 - "To assess in a pediatric population, the clinical characteristics and management of triiodothyronine-predominant Graves' disease (T3-P-GD), a rare condition well known in adults, but not previously described in children. " 06/01/2015 - "Triiodothyronine-predominant Graves' disease in childhood: detection and therapeutic implications."
3.	Hypothyroidism 05/12/2013 - "Recently, several studies suggested to complete it with l-triiodothyronine in acquired hypothyroidism. " 04/01/2000 - "The objective of this study was to test the hypothesis that hypothyroidism [absence of triiodothyronine (-T(3))] and mechanical overload (OV) would convert the plantaris (Plan) muscle from a fast- to a slow-twitch muscle. " 02/13/1980 - "Clinical and biochemical indices of thyroid function were compared in 18 euthyroid control subjects and 54 patients at risk of developing hypothyroidism, and the assessment repeated after a four-week trial of oral triiodothyronine (T3) 40 microgram daily. " 04/01/1960 - "Triiodothyronine in the dog nosis and treatment of hypothyroidism: failure to demonstrate the metabolic insufficiency syndrome (controlled study)." 03/01/1958 - "However, the occasional improvement, sometimes dramatic, suggested that a therapeutic trial with triiodothyronine in difficult or unresponsive cases of hypometabolism or hypothyroidism is justified."
4.	Thyrotoxicosis 01/01/2015 - "Iatrogenic thyrotoxicosis secondary to compounded liothyronine." 01/01/2014 - "Thyroid ultrasound revealed well-defined hypoechogenic clusters in both lobes and laboratorial thyrotoxicosis but low triiodothyronine concentration. " 04/01/2007 - "Case history: thyrotoxicosis factitia secondary to triiodothyronine acquired electronically from abroad." 02/01/1999 - "The results indicate that some of bone and mineral markers change rapidly in response to triiodothyronine-induced acute thyrotoxicosis, but the manner of change is not the same as that of chronic thyrotoxicosis." 11/01/1993 - "Thyrotoxicosis in a depressed patient on L-triiodothyronine."
5.	Body Weight (Weight, Body) 12/01/2015 - "TH induction was evaluated in two ways: 1) in vivo through interperitoneal injection of 10pmol/g body weight of 3,3', 5-triiodothyronine (T3) into premetamorphic tadpoles and analysis after 48h, and 2) in serum-free organ culture in the presence of 10nM T3 after 48h. " 06/01/2015 - "injection of triiodothyronine (at 2 mg/kg of body weight) during 5 days. " 01/01/2015 - "Male Wistar rats were treated for 10 days with triiodothyronine (T3) at a dose of 50µg/100g of body weight. " 01/01/2014 - "From the LI group, we randomly selected 15 mice and injected triiodothyronine (T3, 100 µg/kg body weight per day) intraperitoneally for 24, 48 or 72 hours (5 mice for each time-point). " 01/01/2012 - "Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters."

Related Drugs and Biologics

1.	Thyroxine (Levothyroxine)
2.	Thyrotropin (Thyroid-Stimulating Hormone)
3.	Iodine
4.	Hormones
5.	Antibodies
6.	Oxygen
7.	Hydrocortisone (Cortisol)
8.	Thyroxine-Binding Globulin
9.	Thyroglobulin
10.	Thyrotropin-Releasing Hormone (Protirelin)

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)
2.	Drug Therapy (Chemotherapy)
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Reflexotherapy
5.	Renal Dialysis (Hemodialysis)