Apolipoproteins

Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.

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Networked: 10101 relevant articles (178 outcomes, 1363 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holtzman, David M: 32 articles (11/2015 - 04/2002)
2.	Alzheimer's Disease Neuroimaging Initiative: 29 articles (01/2016 - 04/2009)
3.	Maeda, Nobuyo: 27 articles (01/2015 - 03/2002)
4.	Huang, Yadong: 27 articles (12/2014 - 12/2002)
5.	Vitek, Michael P: 26 articles (01/2014 - 03/2005)
6.	Reiman, Eric M: 25 articles (10/2015 - 06/2002)
7.	Caselli, Richard J: 24 articles (10/2015 - 06/2002)
8.	Kastelein, John J P: 24 articles (06/2015 - 06/2003)
9.	Barrett, P Hugh R: 23 articles (12/2015 - 01/2002)
10.	Weber, Christian: 22 articles (12/2015 - 01/2003)

Related Diseases

1.	Atherosclerosis 12/01/2014 - "Tocopherol supplementation favorably influenced vascular function and cytokine profile, while it was also effective in reducing atherosclerosis in the apolipoprotein E(-/-) mouse with CKD." 05/01/2010 - "Studies on protective effects of human paraoxonases 1 and 3 on atherosclerosis in apolipoprotein E knockout mice." 06/01/2011 - "Furthermore, total or macrophage-specific FABP4 deficiency is protective against atherosclerosis in apolipoprotein E-deficient mice. " 12/01/2015 - "Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice." 06/10/2014 - "Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E(-/-) mice and rabbits. "
2.	Alzheimer Disease (Alzheimer's Disease) 08/01/1999 - "Therefore, we suggested that this fragment is implicated in the neurotoxicity of Abeta and in the protective effects of apolipoprotein E in Alzheimer's disease. " 08/01/2012 - "Both groups showed improvement from baseline in Alzheimer disease risk knowledge (e.g., understanding the magnitude of apolipoprotein E genotype effect on risk). " 01/01/2015 - "Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study." 06/01/2013 - "Exploratory study of apolipoprotein E ε4 genotype and risk of Alzheimer's disease in Mexican Hispanics." 06/01/2011 - "Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study."
3.	Coronary Disease (Coronary Heart Disease) 11/01/1987 - "Serum apolipoprotein measurements: an improved discriminator for assessing coronary heart disease risk." 10/01/2015 - "Apolipoprotein B improves risk assessment of future coronary heart disease in the Framingham Heart Study beyond LDL-C and non-HDL-C." 01/01/2015 - "Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study." 01/01/2014 - "Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls." 10/01/2013 - "Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis."
4.	Hypercholesterolemia 02/28/1995 - "Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes." 12/01/1994 - "The longitudinal design of this study allowed demonstration of the later changes in the apolipoproteins and the presence of a distinct subset of patients with both GH deficiency and hypercholesterolemia. " 06/10/2013 - "Apolipoprotein E gene polymorphisms in Lebanese with hypercholesterolemia." 01/01/2013 - "Effects of Aging and Hypercholesterolemia on Oxidative Stress and DNA Damage in Bone Marrow Mononuclear Cells in Apolipoprotein E-deficient Mice." 01/01/2011 - "Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice."
5.	Hyperlipidemias (Hyperlipidemia) 02/01/2003 - "Our study does not provide evidence for short-term major changes in fasting or postprandial lipemia or apolipoproteins in FCHL when systematically compared to healthy controls." 10/01/1996 - "Our aim is to study the apolipoprotein profile in hyperuricemic patients without hyperlipidemia compared to a control population. " 03/01/1995 - "Identification, molecular characterization, and cellular studies of an apolipoprotein E mutant (E1) in three unrelated families with hyperlipidemia." 01/01/1987 - "New possibilities to study restriction fragment length polymorphisms (RFLPs) at apolipoprotein loci have added a new dimension to research on genetics of CHD and hyperlipidemias. " 01/01/1983 - "Preliminary studies in our laboratory using a simple technique of identifying the 6 phenotypes of the apolipoprotein-E suggest that the isomer E2 may favour the appearance of hyperlipidemia when another genetic or environmental factor is present."

Related Drugs and Biologics

1.	Apolipoproteins E (ApoE)
2.	Lipoproteins (Lipoprotein)
3.	Cholesterol
4.	Apolipoprotein A-I (Apolipoprotein A1)
5.	LDL Cholesterol
6.	Apolipoproteins B (ApoB)
7.	LDL Receptors (LDL Receptor)
8.	Amyloid (Amyloid Fibrils)
9.	Glucose (Dextrose)
10.	Lipids

Related Therapies and Procedures

1.	Ligation
2.	Aftercare (After-Treatment)
3.	Lasers (Laser)
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Cardiopulmonary Resuscitation (CPR)