Hemoglobins (Hemoglobin)

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

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Networked: 20443 relevant articles (733 outcomes, 1922 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lang, Florian: 55 articles (08/2015 - 07/2009)
2.	Gladwin, Mark T: 50 articles (11/2015 - 12/2002)
3.	Fucharoen, Suthat: 23 articles (06/2015 - 08/2002)
4.	Jilani, Kashif: 23 articles (05/2014 - 01/2011)
5.	Singh, Ajay K: 23 articles (02/2013 - 03/2005)
6.	Buehler, Paul W: 21 articles (12/2015 - 10/2005)
7.	Selvin, Elizabeth: 21 articles (07/2015 - 09/2004)
8.	Fucharoen, Supan: 20 articles (01/2016 - 10/2003)
9.	Kim-Shapiro, Daniel B: 20 articles (11/2015 - 07/2003)
10.	Schild, Steven E: 20 articles (01/2015 - 04/2005)

Related Diseases

1.	Anemia 09/01/2007 - "Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin concentrations were those who had anemia at baseline and those with highly positive microhematuria scores at baseline. " 07/01/1980 - "Anemia is the abnormality most likely to be encountered, and investigation of a marginal reduction in the hemoglobin level of an elderly patient may be rewarded with a specific diagnosis of a disease that can be effectively treated, at least for a time." 10/01/2013 - "To improve patients' outcomes, further study is required to more fully explore the risk of anemia, optimal hemoglobin level, and the risk and efficacy of RBC transfusion. " 01/01/1996 - "In univariate analysis, factors associated with poor survival were stage IV (Ann Arbor staging system), anemia (hemoglobin level less than 10g/dl), bone marrow involvement, two or more extranodal sites, and failure in induction of complete remission (CR) in the entire course. " 05/01/1991 - "After operation, the anemia markedly improved while rHuEPO was administered, but the hemoglobin levels decreased rapidly when the administration was terminated. "
2.	Neoplasms (Cancer) 03/10/2004 - "With the depth correction, more uniform absorption maps for target layers at different depths are obtained from the phantoms, and the correlation between the reconstructed hemoglobin concentration maps of deeply located, large cancers and the histological microvessel density counts are dramatically improved." 10/01/2013 - "On multivariate analysis, improved LRC was significantly associated with pre-RT hemoglobin levels≥12 g/dl (risk ratio [RR] 2.22; 95% confidence interval [CI] 1.19–4.13; p=0.013), tumor site (RR 1.39; 95% CI 1.14–1.70; p=0.001), lower T category (RR 1.67; 95% CI 1.18–2.44; p=0.003), and lower N category (RR 4.18; 95% CI 1.90–10.55; p<0.001). " 10/01/2011 - "Improved treatment outcomes were significantly associated with positive HPV status, better performance status, lower tumor stage, and pretreatment hemoglobin levels ≥ 12 g/dl. " 05/01/2002 - "An aggressive combination of immunoactive Nutraceuticals was effective in significantly increasing NK function, other immune parameters and hemoglobin from PBMC or plasma in patients with late stage cancers. " 03/01/2009 - "Malignant cancers (N=41) showed statistically significant higher total hemoglobin, oxy-hemoglobin concentration, and scattering compared to normal tissue. "
3.	Body Weight (Weight, Body) 01/01/2014 - "There was a significant reduction in hemoglobin A1c (HbA1c, -0.2 ± 0.56% versus 0.08 ± 0.741%; P < 0.05) and body weight (-1.19 ± 1.39 kg versus -0.61 ± 2.04 kg; P < 0.05) in the intervention group as compared to the control group. " 01/01/2012 - "A significant reduction in body weight, waist circumference and glycated hemoglobin was observed in the intervention group compared with the control group. " 07/01/2007 - "Patients who had negative changes in absolute lymphocyte count, hemoglobin concentration and body weight had 3.1 (1.6 to 6.2), 3.2 (1.6 to 6.2), and 3.5 (1.9 to 6.4) times significantly greater risk of treatment failure. " 05/01/2007 - "There was significant improvement in body weight (children--baseline 18.9 [5.8] Kg, follow up 27.4 [12.4] Kg; adults--baseline 47.6 [18.2] Kg, follow up 54.9 [5.1] Kg) and hemoglobin (children--8.1 [2.0] g/dL to 11.2 [1.4] g/dL; adults--7.3 [2.3] g/dL to 9.7 [1.7] g/dL) in both groups after one year of GFD; duodenal biopsy also improved, with a majority of patients attaining normal to IIIa Marsh grading. " 08/01/2007 - "The rats' general state of health, body weight, internal organs coefficient has not been affected, the hemoglobin, the red blood cell, the kidney function and liver function have been affected, and has some toxic effect on the rats' white blood cell and cardic muscle, the toxic effect on cardic muscle was increase along with the rate of Sargassum and Radix Glycyrrhizae; liver drug enzyme activity has been improved. "
4.	Hemorrhage 12/01/2010 - "One of these 12 cases, who also had a marked decrease in hemoglobin level without bleeding, was suspected to have Evans syndrome. " 08/01/2010 - "Marked decrease in hemoglobin value was more frequent in patients with re-bleeding than those without (P = 0.07). " 08/01/2010 - "Marked decrease in hemoglobin value [OR; 18.8, 95% CI; 3.4-152.0] and earlier CE examination within a week after the last episode of bleeding [OR; 8.0, 95% CI; 2.2-35.9] were factors associated with positive CE findings. " 07/01/2015 - "On univariate analysis, large HH, frequent non-steroidal anti-inflammatory drug (NSAID) use, GI bleeding (both occult and overt), and nadir hemoglobin level were significantly greater with Cameron lesions compared with HH without Cameron lesions (P ≤ 0.03). " 10/01/1999 - "It is superior to high-frequency surgical units and high-frequency coagulating intermittent cutting in terms of whole intraoperative bleeding (hemoglobin tested before and after surgery) and for the impressive impact on minimizing postoperative bleeding. "
5.	Weight Loss (Weight Reduction) 04/01/1991 - "Important factors for improved survival, according to the Cox regression analysis, were the stage of disease, performance status, sex, weight loss before diagnosis, and hemoglobin concentration." 09/01/2015 - "While Look AHEAD (action for HEAalth in diabetes) study showed significant weight loss, reduction in glycated hemoglobin and higher remission rate of T2DM at 1(st) year following intensive lifestyle measures; recurrence and relapse rate bounced back in half of subjects at 4 years, thereby indicating that weight loss and glycemic control is difficult to maintain in the long term with lifestyle interventions. " 01/01/2013 - "During the 12 weeks of intervention the SMBG group significantly improved glycated hemoglobin (HbA1c) levels (from 7.4 ± 1.6% to 6.9 ± 1.1% [P<0.001]) and weight (-0.9 ± 1.9 kg [P<0.05]), whereas HbA1c reduction (from 7.5 ± 1.0% to 7.3 ± 1.0%) and weight loss (-0.6 ± 2.4 kg) were not significant in the control group. " 09/13/2013 - "The aim of the present study was to determine whether weight reduction is associated with improvement of glycemic control in non-obese and obese subjects with or without visceral fat accumulation, whose hemoglobin A1c (A1C) is 5.6-6.4%. " 06/05/2013 - "Three randomized clinical trials (RCTs) (N = 290; including 1 trial of 150 patients with type 2 diabetes and mean BMI of 37, 1 trial of 80 patients without diabetes [38% with metabolic syndrome] and BMI of 30 to 35, and 1 trial of 60 patients with diabetes and BMI of 30 to 40 [13 patients with BMI <35]) found that surgery was associated with greater weight loss (range, 14.4-24 kg) and glycemic control (range, 0.9-1.43 point improvements in hemoglobin A1c levels) during 1 to 2 years of follow-up than nonsurgical treatment. "

Related Drugs and Biologics

1.	Oxygen
2.	Iron
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	Erythropoietin
6.	Epoetin Alfa (Epogen)
7.	Blood Glucose (Blood Sugar)
8.	Ferritins (Ferritin)
9.	Liposomes (Liposome)
10.	Creatinine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Blood Transfusion (Blood Transfusions)
3.	Resuscitation
4.	Oral Administration
5.	Hemodilution