Abstract | AIM OF THE STUDY: CLINICAL RATIONALE FOR THE STUDY: Blood-brain-barrier (BBB) disruption is one of the key pathological processes involved in various demyelinating diseases of the central nervous system (CNS) and is associated with shedding of cell adhesion molecules and S100B into the serum compartment. Therefore, making an assessment of serum levels of the above-mentioned molecules could provide information about disease pathogenesis, severity of BBB disruption, and disease activity. MATERIAL AND METHODS: RESULTS: We found the lowest levels of sPECAM-1, sICAM-1 and S100B in sera from NMOsd patients. The highest levels of sPECAM-1 and sICAM-1 were observed in NPSLE, and in NPSLE and MS, respectively. There were no statistically significant differences in sVCAM-1 levels between the examined groups. In MS and NMOsd, there was a negative correlation between the EDSS score and the following molecules: sPECAM-1, sICAM-1 and S100B. CONCLUSIONS AND CLINICAL IMPLICATIONS: We conclude that there is a different profile of blood-brain-barrier disruption reflected by cell adhesion molecules shedding in the spectrum of autoimmune CNS disorders with disseminated white matter lesions. These molecules could become new biomarkers to be used in CNS demyelinating diseases differential diagnoses and monitoring disease activity, but further studies on larger groups of patients are necessary.
|
Authors | Michalina Jasiak-Zatońska, Anna Pietrzak, Aleksandra Wyciszkiewicz, Ewa Więsik-Szewczyk, Katarzyna Pawlak-Buś, Piotr Leszczyński, Wojciech Kozubski, Sławomir Michalak, Alicja Kalinowska-Łyszczarz |
Journal | Neurologia i neurochirurgia polska
(Neurol Neurochir Pol)
Vol. 56
Issue 3
Pg. 246-255
( 2022)
ISSN: 0028-3843 [Print] Poland |
PMID | 35118639
(Publication Type: Journal Article)
|
Topics |
- Blood-Brain Barrier
- Humans
- Lupus Vasculitis, Central Nervous System
- Multiple Sclerosis
(drug therapy)
- Multiple Sclerosis, Relapsing-Remitting
(drug therapy)
- Neuromyelitis Optica
(drug therapy)
|