Pathologic Processes

08/14/2009 - "Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system and play important roles in a variety of physiological and pathological processes. "
04/01/2004 - "Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system, and play important roles in a variety of normal biochemical functions and abnormal pathological processes. "
12/02/2014 - "A method for identifying each cell secreting reactive oxygen species (ROS) is highly desirable to advance the understanding of the physiological and pathological processes attributed to extracellular ROS. "
07/01/2014 - "Oxidative base damage occurs spontaneously due to reactive oxygen species generated as byproducts of respiration and other pathological processes in mammalian cells. "
01/10/2014 - "Mitochondrial and cellular reactive oxygen species (ROS) play important roles in both physiological and pathological processes. "

02/01/2015 - "To date, these studies have aided our understanding of the pathological processes associated with illness much more than they have provided robust biomarkers. "
03/09/2010 - "High-throughput R-fMRI can provide quantitative phenotypes for molecular genetic studies and biomarkers of developmental and pathological processes in the brain. "
12/01/2000 - "The BPF is an informative surrogate marker for destructive pathological processes in relaping MS patients, and is useful in demonstrating treatment effects in controlled clinical trials. "
12/01/2015 - "Biomarkers serve as objective molecular indicators of pathological processes. "
09/01/2015 - "They are considered as universal biomarkers in a wide range of physiological and pathological processes. "

01/01/1989 - "Finally, oxygen dissociation curves in single red blood cells can be obtained by means of particular flow cell, with promising results for the study of physiological and pathological processes (namely red cell sickling in drepanocytosis)."
11/01/2015 - "A qualitative and quantitative morphological study of the pulmonary exchange capacity of healthy and diseased Burmese pythons (Python molurus) was carried out in order to test the hypothesis that the high morphological excess capacity for oxygen exchange in the lungs of these snakes is one of the reasons why pathological processes extend throughout the lung parenchyma and impair major parts of the lungs before clinical signs of respiratory disease become apparent. "
03/01/2012 - "Based on the ease and customizability of the synthesis of the nanoparticles and the flexibility of their application, these oxygen-sensing polymeric nanoparticles will find a natural home in a range of biological applications, benefiting studies of physiological as well as pathological processes in which oxygen availability and concentration play a critical role."
11/01/2008 - "Mechanisms of oxygen sensing and regulation underlie many physiological and pathological processes, and only a handful of oxygen regulators have been identified in previous studies. "
01/01/2008 - "Study of Hb-DNIC interaction with reactive oxygen metabolites is important for understanding NO and Hb roles in pathological processes that could result from oxidative stress."

01/01/2012 - "This review focused on the new developments of amyloid cascade hypothesis with details on the production, metabolism and clearance of A-beta, and the key roles of some important A-beta-related genes in the pathological processes of AD. "
01/01/2013 - "Changes in the brain vasculature have been shown to contribute to the onset and progression of the pathological processes associated with AD, such as microvascular reductions, blood brain barrier (BBB) breakdown, and faulty clearance of amyloid β-peptide (Aβ) from the brain. "
09/01/2011 - "Furthermore, animal studies indicate that volatile anaesthestics may augment the pathological processes of AD by affecting amyloid-beta processing. "
01/01/2016 - "Together, DAT and amyloid PET imaging discriminate DLB from PD and from other disease groups and identify pathological processes that contribute to their course. "
12/01/2015 - "Here, we discuss recent experimental discoveries which suggest that amyloid fibres should be considered as disease-relevant species that can mediate a range of pathological processes. "

11/01/1999 - "The study of plasma cytokine levels is also of limited value, and complementary methods are now available to investigate and understand more precisely the involvement of cytokines in pathological processes."
07/01/1999 - "This study demonstrates that, even in apparently healthy subjects, age-associated immune activation indicated by raised levels of pro-inflammatory cytokines may reflect age-associated pathological processes that develop over decades."
01/01/2016 - "The neuroanatomical correlation patterns of 2 proinflammatory cytokines and 2 vascular IMs might be reflective of the effects of neurodegenerative and vascular pathological processes in the ageing brain. "
12/01/2015 - "The TGF-β superfamily consists of a large group of pleiotropic cytokines that are involved in the regulation of many developmental, physiological and pathological processes. "
02/01/2015 - "Macrophage-derived cytokines fuel the pathological processes in RA and are targets of clinically successful therapies. "

09/01/1982 - "It is suggested that this antibody will be of value in research on the structure of human basement membrane collagen, on the distribution of this collagen in various basement membranes, and particularly for the study of basement membranes in normal human development and pathologic processes."
04/01/2015 - "Changes in the morphology of dermal collagen may indicate aging or pathological processes. "
01/01/2014 - "The submucosa amount of collagen fibers was significant and their orientation suffering proportional changes with the development of the pathological processes. "
01/01/2012 - "Collagen IV in Normal Skin and in Pathological Processes."
09/25/2009 - "Collagen, known for its structural role in tissues and also for its participation in the regulation of homeostatic and pathological processes in mammals, is assembled from triple helices that can be either homotrimers or heterotrimers. "

01/01/2008 - "Protein arginine methylation is a rapidly growing field of biomedical research that holds great promise for extending our understanding of developmental and pathological processes. "
04/01/2009 - "Thus, protein arginine methylation is critical for regulation of transcription and potentially for various physiological/pathological processes."
08/01/1997 - "To prevent or treat these pathological processes, in which a deficiency in vascular NO formation plays a causative role, NO may be provided through methods such as direct NO administration or indirect NO supply through either NO donors or L-arginine, which facilitates NO formation."
02/01/2016 - "Arginine is receiving great attention in recent years because it is the substrate for the synthesis of nitric oxide, an important signaling molecule involved in numerous physiological and pathological processes in mammals. "
11/01/2012 - "The lack of methods for proteome-scale detection of arginine methylation restricts our knowledge of its relevance in physiological and pathological processes. "

08/20/2014 - "Improved understanding of the roles of redox-based reactions in regulation of voltage-gated calcium channels may lead to improved understanding of novel redox mechanisms in physiological and pathological processes. "
09/01/2011 - "Voltage-gated calcium channels play an important role in many physiological and pathological processes. "
05/01/2000 - "These results suggest that this unique cardiovascular profile of AH-1058 may become beneficial for the treatment of certain pathologic processes, in which selective inhibition of ventricular calcium channels would be essential for drug therapy."

06/09/2000 - "These results suggest that AH-1058 can become a long-acting Ca(2+) channel blocker with unique antiarrhythmic properties, and that AH-1058 may be used in certain pathological processes, for which selective inhibition of the cardiac Ca(2+) channels is essential."
01/01/2001 - "This unique cardiovascular profile of AH-1058 is expected to be useful in the treatment of certain pathological processes such as the obstructive hypertrophic cardiomyopathy, vasovagal syncope, dissecting aortic aneurysm, and ventricular arrhythmias, in which selective inhibition of the ventricular Ca2+ channels is essential for drug therapy."
05/01/2000 - "These results suggest that this unique cardiovascular profile of AH-1058 may become beneficial for the treatment of certain pathologic processes, in which selective inhibition of ventricular calcium channels would be essential for drug therapy."

10/30/2012 - "Further examination in larger populations of these proteins may help to gain a better understanding of DS pathological processes and improve DS treatments."
03/15/2015 - "This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. "
01/01/2013 - "In recent years proteomics has been successfully applied to study proteins involved in these pathological processes. "
01/01/2012 - "Some of the observed changes include genes and proteins that have been identified in a number of other pathological processes, such as TGF-β, some which may be more specific to DD, such as ADAM12, and undoubtedly also some that have yet to be discovered in future studies. "
11/05/2010 - "The identification of sCJD-regulated proteins in CSF of living symptomatic patients in our study can broaden our knowledge about pathological processes occurring in sCJD, as they are still not fully understood."

02/09/2001 - "This unique cardiovascular profile may be beneficial for the treatment of certain pathological processes in which selective inhibition of the ventricular Ca(2+)channels would be the target of drug therapy."
01/01/2013 - "In conjunction with other sciences such as genomics and bioinformatics it will be possible to diagnose diseases on the earliest stages before its clinical onset or to gain the dynamics of pathological processes in the body and response to drug therapy. "
03/01/2010 - "For decades, oncologists have concentrated on delineating the pathological processes, which occur within the gastrointestinal tract during chemotherapy treatment. "
01/01/1968 - "[Topical drug therapy of pathologic processes in the mouth complicated by changes in the oral pH]."
05/01/2012 - "Because currently available therapies cannot reverse the pathologic processes of AD, the primary objective of pharmacotherapy is to preserve cognitive and functional ability, minimize behavioral disturbances, and slow disease progression. "

08/01/2015 - "EVs have significant promise for therapeutics and diagnostics and for understanding physiological and pathological processes all of which have boosted research to find modulators of their composition, secretion and targeting. "
06/15/2014 - "The emerging role of the transient receptor potential cation channel isotype 6 (TRPC6) as a central contributor to various pathological processes affecting podocytes has generated interest in the development of therapeutics to modulate its function. "
05/01/2014 - "EVs participate in physiological and pathological processes and have potential applications in diagnostics or therapeutics. "
01/01/2014 - "Intracrine biology plays a role in many normal and pathological processes and represents a fertile field for the development of novel therapeutics. "
01/01/2013 - "This review will focus on exosomes as intercellular signaling organelles involved in a number of physiological as well as pathological processes and their potential use in clinical diagnostics and therapeutics."

06/01/2008 - "Accurate diagnosis and grading of rejection and other pathological processes are of paramount importance to guide therapeutic interventions in patients with pancreas allograft dysfunction. "
05/01/2006 - "A renal biopsy is necessary to exclude other pathologic processes (e.g., acute rejection) that could coexist with BKPVAN or be the main cause of allograft dysfunction. "
07/01/2001 - "Transient expression of therapeutic genes within lung allografts may modulate the pathological processes following allotransplantation. "
01/01/1999 - "It is concluded that the protocol biopsy is apparently useful for the detection of various pathological processes occurring in allograft and may contribute to a strategy for improvement of graft survival."
03/01/1998 - "Distribution of alpha and beta cells in pancreas allograft biopsies: correlation with rejection and other pathologic processes."

06/01/2009 - "The additional information provided by 3D study was very useful for evaluation of mitral valve disease and mitral valve prostheses, enabling quick and reliable recognition of the cardiac anatomy and the pathological processes involved in each case. "
04/01/1992 - "No pathologic processes were observed as a result of use of the prosthesis. "
08/01/1991 - "Part I of this review discusses the pathologic processes responsible for degeneration of porcine prostheses: intrinsic calcification (mineralization), cuspal tears and perforations, and cuspal thrombosis (non-infective). "
07/01/2009 - "Prosthesis dysfunction includes a group of pathological processes like thrombosis, thromboemboli, valvular or paravalvular regurgitation, patient-prosthesis mismatch, infective endocarditis and bioprosthesis degeneration. "

01/01/2005 - "Primary biological incompatibilities of the xenograft in the regulation of clotting appear to amplify pathological processes associated with rejection. "
11/01/2010 - "However, intentionally induced, it ameliorates pathological processes like ischemia reperfusion injury, allograft, xenograft or islet rejection, facilitates donor specific tolerance and alleviates chronic allograft changes. "
03/01/2002 - "Complement plays a critical role in many pathologic processes and in xenograft rejection. "
06/15/2000 - "Inasmuch as complement plays a critical role in many pathological processes and in xenograft rejection, efficient complement inhibitors are of great interest. "