Demyelinating Diseases (Demyelinating Disease)

Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Also Known As:
Demyelinating Disease; Demyelination; Clinically Isolated CNS Demyelinating Syndrome; Clinically Isolated Syndrome, CNS Demyelinating; Demyelinating Disorders; Demyelinating Disorder; Demyelinations
Networked: 4926 relevant articles (169 outcomes, 538 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Sclerosis
2. Inflammation
3. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
4. Infection
5. Spinal Cord Injuries (Spinal Cord Injury)


1. Rodriguez, Moses: 36 articles (03/2015 - 01/2002)
2. Franklin, Robin J M: 33 articles (12/2015 - 04/2002)
3. Lassmann, Hans: 29 articles (12/2015 - 06/2002)
4. Stangel, Martin: 25 articles (12/2015 - 11/2003)
5. Brück, Wolfgang: 24 articles (10/2015 - 09/2005)
6. Zhao, Chao: 21 articles (12/2015 - 04/2002)
7. Baumgärtner, Wolfgang: 21 articles (11/2015 - 04/2002)
8. Kim, Byung S: 19 articles (07/2015 - 07/2002)
9. Blakemore, W F: 19 articles (02/2008 - 01/2000)
10. Skripuletz, Thomas: 18 articles (12/2015 - 04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Demyelinating Diseases:
1. CuprizoneIBA
2. AntibodiesIBA
3. AntigensIBA
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
5. Adrenal Cortex Hormones (Corticosteroids)IBA
6. Complement System Proteins (Complement)IBA
7. oligodendrocyte-myelin glycoproteinIBA
8. Immunoglobulins (Immunoglobulin)IBA
9. SodiumIBA
12/01/1972 - "Propagation continued past a single demyelinated internode until myelin thickness was uniformly reduced to less than 2.7% of normal myelin thickness.3. Paranodal demyelination was more effective in slowing impulse conduction than was uniform demyelination of an entire internode with an equivalent rise in overall internodal capacitance and conductance.4. The effects on conduction of demyelination of two adjacent internodes or of two internodes separated by a normal internode were more than the sum of the effects of demyelination of each internode individually.5. Propagation across a severely demyelinated internode was blocked with an increase in internal sodium concentration which had a trivial effect on conduction in a normal fibre.6. Propagation across a severely demyelinated internode was blocked with increased temperature at a temperature at which propagation proceeds normally across normal internodes.7. The similarity between the findings of the computer simulations and the experimental findings in demyelinated fibres is discussed."
12/01/2015 - "Current guidelines recommend serum sodium concentration correction targets of no more than 8 mEq/L per day in patients at high risk of osmotic demyelination syndrome. "
10/01/2015 - "We investigated the association between sodium correction and demographic and outcome variables, including occurrence of osmotic demyelination syndrome (ODS). "
04/01/2015 - "However, an overly rapid correction of serum sodium levels can lead to osmotic demyelination syndrome (ODS), a dreadful neurological picture. "
12/01/2014 - "This case report demonstrates that if serum sodium is re lowered early in the course of Osmotic demyelination syndrome (ODS), many of its devastating consequences may be avoided. "
10. Choline (Choline Chloride)IBA

Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Transplants (Transplant)
3. Plasmapheresis
4. Plasma Exchange
5. Immunomodulation