Abstract | BACKGROUND: METHODS: RESULTS: Fasting glucose levels were increased in animals with colitis compared to controls. GLP-1 was decreased in both serum and colon of mice with colitis in comparison to the control group. DPP IV levels were significantly increased in serum, but not in the colon of mice with colitis as compared to healthy animals. Furthermore, PC 1/3 and GLP-1R expression levels were increased in mice with colitis as compared to controls. In humans, no differences were observed in fasting glucose level between healthy subjects and CD patients. GLP-1 levels were significantly decreased in the serum. Interestingly, GLP-1 level was significantly increased in colon samples of CD patients compared to healthy subjects. No significant differences in DPP IV levels in serum and colon samples were observed between groups. CONCLUSIONS: Changes in the incretin system during colitis seem to contribute to the impaired glucose levels. Differences in incretin levels seem to be modulated by degrading enzyme DPP-IV and PC 1/3. Obtained results suggest that the incretin system may become a novel therapeutic approach in the treatment of CD.
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Authors | Hubert Zatorski, Maciej Salaga, Marta Zielińska, Anna Mokrowiecka, Damian Jacenik, Wanda Małgorzata Krajewska, Ewa Małecka-Panas, Jakub Fichna |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
Vol. 73
Issue 6
Pg. 1670-1679
(Dec 2021)
ISSN: 2299-5684 [Electronic] Switzerland |
PMID | 34535873
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Blood Glucose
- Incretins
- Glucagon-Like Peptide 1
- Trinitrobenzenesulfonic Acid
- Dipeptidyl Peptidase 4
- Proprotein Convertase 1
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Topics |
- Adult
- Animals
- Blood Glucose
(metabolism)
- Case-Control Studies
- Colitis
(pathology)
- Crohn Disease
(pathology)
- Dipeptidyl Peptidase 4
(metabolism)
- Disease Models, Animal
- Female
- Glucagon-Like Peptide 1
(blood)
- Humans
- Incretins
(metabolism)
- Inflammation
(pathology)
- Male
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Proprotein Convertase 1
(genetics)
- Trinitrobenzenesulfonic Acid
- Young Adult
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