Crohn Disease (Crohn's Disease)

A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Also Known As:
Crohn's Disease; Crohns Disease; Colitis, Granulomatous; Enteritis, Granulomatous; Enteritis, Regional; Ileitis, Regional; Ileitis, Terminal; Ileocolitis
Networked: 12139 relevant articles (1624 outcomes, 1678 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Ulcerative Colitis
2. Rheumatoid Arthritis
3. Fistula
4. Necrosis
5. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)


1. Rutgeerts, Paul: 135 articles (01/2016 - 01/2002)
2. Sandborn, William J: 119 articles (01/2016 - 01/2002)
3. Van Assche, Gert: 64 articles (12/2015 - 08/2002)
4. Hanauer, Stephen B: 63 articles (11/2014 - 05/2002)
5. Feagan, Brian G: 59 articles (12/2015 - 01/2002)
6. Colombel, Jean-Frédéric: 57 articles (01/2016 - 01/2002)
7. Rutgeerts, P: 54 articles (04/2015 - 01/2000)
8. Rogler, Gerhard: 53 articles (12/2015 - 05/2002)
9. Vermeire, Séverine: 52 articles (12/2015 - 05/2004)
10. Schreiber, Stefan: 52 articles (01/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crohn Disease:
1. infliximab (Remicade)FDA Link
2. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
3. adalimumab (Humira)FDA Link
4. Azathioprine (Imuran)FDA LinkGeneric
5. Adrenal Cortex Hormones (Corticosteroids)IBA
6. Mesalamine (Mesalazine)FDA LinkGeneric
7. Methotrexate (Mexate)FDA LinkGeneric
8. 6-Mercaptopurine (Mercaptopurine)FDA LinkGeneric
9. Budesonide (Pulmicort)FDA LinkGeneric
10. SteroidsIBA

Therapies and Procedures

1. Enteral Nutrition (Feeding, Tube)
2. Remission Induction
3. Biological Therapy
4. Drug Therapy (Chemotherapy)
06/01/2015 - "Intestinal resection of all macroscopic Crohn's disease in patients treated with postoperative prophylactic drug therapy is associated with significant and sustained improvement in HRQoL irrespective of type of drug treatment or endoscopic recurrence. "
04/01/1992 - "We have conducted a meta-analysis of 12 placebo controlled trials to determine the efficacy of single drug therapy in Crohn's disease for both induction (seven trials) and maintenance (five trials) of remission. "
01/01/2013 - " Target disease: Crohn's disease Users: Clinical practitioners in internal medicine, surgery, gastroenterology, and general practice Purpose: To provide appropriate clinical indicators to practitioners Scope of clinical indicators: Concept of Crohn's disease, epidemiology, classifications, diagnosis, treatment, follow up, and special situations Intervention: Diagnosis (interview, physical examination, clinical laboratory tests, imaging, and pathology) and treatment (lifestyle guidance, drug therapy, nutritional therapy, surgery, etc.) Outcome assessment: Attenuation of symptoms, induction and maintenance of remission, imaging findings, quality of life (QOL), prevention of complications and harm of therapy Methods for developing these guidelines: Described in the text Basis of recommendations: Integration of evidence level and consensus of experts Cost-benefit analysis: Not implemented Evaluation of effectiveness: Yet to be confirmed Status of guidelines: Updated version of the first Guidelines published in 2010 Publication sources: Printed publication available and electronic information in preparation Patient information: Not available Date of publication: October 2011 These guidelines were intended primarily to be used by practitioners in Japan, and the goal of these guidelines is to improve the outcomes of patients with Crohn's disease."
12/01/2001 - "Various drugs (and/or surgery in Crohn's disease) are used to induce remission, and maintenance drug therapy is commonly given to prevent relapse once remission is achieved. "
12/12/1987 - "Remission of Crohn's disease with antimycobacterial chemotherapy."
5. Total Parenteral Nutrition