Abstract | OBJECTIVES:
Latent Tuberculosis infection (LTBI) is postulated to modulate immune responses and alter disease severity in SARS-CoV-2 co-infection. However, no data exist on the effect of LTBI on the immune responses in SARS-CoV-2 co-infected individuals. METHODS: RESULTS: Our results demonstrated that individuals with LTBI (LTBI+) and seropositive for SARS-CoV-2 infection were associated with elevated SARS-CoV-2 specific IgM, IgG and IgA antibodies, as well as enhanced neutralization activity compared to those negative for LTBI (LTBI-) individuals. Our results also demonstrate that LTBI+ individuals exhibited significantly higher plasma levels of IFNγ, IL-2, TNFα, IL-1α, IL-1β, IL-6, IL-12, IL-15, IL-17, IL-3, GM-CSF, IL-10, IL-25, IL-33, CCL3 and CXCL10 compared to LTBI- individuals. Finally, our results show that LTBI+ individuals exhibit significantly higher levels of C-reactive protein, alpha-2 macroglobulin, VEGF and TGFα compared to LTBI- individuals. CONCLUSIONS:
|
Authors | Anuradha Rajamanickam, Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Arul Nancy, Nandhini Selvaraj, Kushiyasri Karunanithi, Saravanan Munisankar, Shrinivasa Bm, Rachel Mariam Renji, T C Ambu, Vijayalakshmi Venkataramani, Subash Babu |
Journal | The Journal of infection
(J Infect)
Vol. 83
Issue 3
Pg. 339-346
(09 2021)
ISSN: 1532-2742 [Electronic] England |
PMID | 34329676
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
|
Topics |
- Acute-Phase Reaction
- COVID-19
- Coinfection
- Cytokines
- Humans
- Latent Tuberculosis
(complications)
- SARS-CoV-2
|