Abstract | OBJECTIVE: DESIGN: Two-dimensional and three-dimensional cell culture study of immortalized human leiomyoma and patient-matched myometrium cells treated with simvastatin. SETTING: University laboratory. PATIENT(S): None. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Cell proliferation, alteration in apoptotic signaling pathways, and extracellular matrix (ECM) protein production. RESULT(S): CONCLUSION(S):
Simvastatin induces apoptosis in uterine leiomyoma cells at low concentrations, as evidenced by increased active caspase levels. Furthermore, inhibited production of the ECM proteins may lead to reduction in tumor size. Simvastatin may represent a novel therapeutic treatment strategy for uterine leiomyomas.
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Authors | Minnie Malik, Joy Britten, Mostafa Borahay, James Segars, William H Catherino |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 110
Issue 7
Pg. 1398-1407.e1
(12 2018)
ISSN: 1556-5653 [Electronic] United States |
PMID | 30503138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Published by Elsevier Inc. |
Chemical References |
- Glycoproteins
- Versicans
- Collagen
- Simvastatin
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Topics |
- Apoptosis
(drug effects)
- Cell Proliferation
(drug effects)
- Collagen
(metabolism)
- Dose-Response Relationship, Drug
- Extracellular Matrix
(drug effects, metabolism)
- Female
- Glycoproteins
(metabolism)
- Humans
- Leiomyoma
(pathology)
- Myometrium
(drug effects, metabolism, pathology, ultrastructure)
- Signal Transduction
(drug effects)
- Simvastatin
(pharmacology)
- Tumor Cells, Cultured
- Uterine Neoplasms
(pathology)
- Versicans
(metabolism)
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