Versicans (Versican)

HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.

Also Known As:

Networked: 529 relevant articles (12 outcomes, 87 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wight, Thomas N: 45 articles (03/2024 - 03/2002)
2.	Frevert, Charles W: 12 articles (03/2024 - 02/2014)
3.	Catherino, William H: 12 articles (01/2019 - 09/2008)
4.	Merrilees, Mervyn J: 12 articles (01/2017 - 03/2002)
5.	Yang, Burton B: 12 articles (05/2013 - 04/2002)
6.	Bassols, Anna: 11 articles (02/2011 - 02/2002)
7.	Malik, Minnie: 10 articles (01/2019 - 09/2008)
8.	Ricciardelli, Carmela: 10 articles (01/2015 - 04/2002)
9.	Chan, Christina K: 9 articles (03/2024 - 02/2009)
10.	Chang, Mary Y: 9 articles (03/2024 - 02/2014)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "Patients with versican expression in tumor epithelial cells had significantly better 5-year disease-free (p=0.021) and overall (p=0.034) survival rates, whereas versican expression in stromal cells was not associated with disease-free (p=0.532) and overall (p=0.876) survival. " 01/01/2024 - "In this study, we aimed to assess the diagnostic role of versican (VCAN), a molecule participating in the epithelial-mesenchymal transition, on the detection of metastatic cancer. " 05/01/2008 - "Intracellular versican expression in mesenchymal spindle cell tumors contrasts with extracellular expression in epithelial and other tumors--a tissue microarray-based study." 05/15/2007 - "This study further supports the importance of versican in cancer cell biology and the complexity of apoptosis regulation." 03/20/2023 - "Versican and IKKβ are mutually addicted and/or overexpressed in human cancers and possess diagnostic and prognostic power. "
2.	Infections 09/05/2022 - "In contrast, vaccination with Versican Plus L4 only prevented infection by Australis and shedding by Grippotyphosa and Australis but it did not lead to any statistically significant reduction of either infection or shedding following an Icterohaemorrhagiae challenge." 12/01/2017 - "Growing evidence suggests that versican is important in the innate immune response to lung infection. " 12/01/2015 - "These data suggest that versican plays an important role in fundamental, overlapping cellular processes in lung development and infection." 11/01/2021 - "These data also provide a guide for future studies to determine the role of versican in the pulmonary immune response to influenza infection." 11/01/2016 - "Influenza virus infection of Adamts5-/- mice resulted in delayed virus clearance, compromised T cell migration and immunity and accumulation of versican, an ADAMTS5 proteoglycan substrate. "
3.	Myocardial Infarction 08/01/2016 - "The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study." 12/01/2005 - "To test the hypothesis that versican expression is transiently upregulated and plays a role in the infarcted heart, we examined its expression in a rat model of myocardial infarction. " 12/01/2005 - "Versican is induced in infiltrating monocytes in myocardial infarction." 01/01/2024 - "In adult mice, intramyocardial injection of versican after myocardial infarction enhanced cardiomyocyte proliferation, reduced fibrosis, and improved cardiac function. " 01/01/2021 - "Expression of versican mRNA transcript to predict cardiac remodelling after myocardial infarction."
4.	Inflammation (Inflammations) 01/01/2012 - "Therefore, versican could be the first step in the amplification of the inflammatory response, and ongoing research of this molecule may help to explain the pathogenesis of inflammation." 04/01/2014 - "Collectively, these studies indicate that versican as an ECM molecule plays a central role in inflammation and as a result it is emerging as a potential target promising wide therapeutic benefits. " 04/29/2024 - "Versican (VCAN) is a key factor in inflammation through interactions with adhesion molecules. " 01/01/2022 - "Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination." 11/01/2020 - "In contrast, versican is transiently expressed at high levels during development and under pathological conditions when the extracellular matrix dramatically changes, including in the inflammation and repair process. "
5.	Colonic Neoplasms (Colon Cancer) 12/01/2013 - "Lumican and versican are associated with good outcome in stage II and III colon cancer." 11/20/2002 - "In this study, the amounts and the fine structural characteristics of versican and decorin present in human colon adenocarcinomas (HCC) were investigated and compared with those in human normal colon (HNC). " 11/20/2002 - "These findings indicate that the colon adenocarcinoma is characterized by a remarkable increase in the concentration of versican and decorin. " 11/20/2002 - "Human colon adenocarcinoma is associated with specific post-translational modifications of versican and decorin." 09/28/1990 - "Hypomethylation can be observed in both benign and malignant colonic neoplasms; however, there is no correlation with increased expression since versican mRNA levels do not significantly vary between normal and neoplastic tissues. "

Related Drugs and Biologics

1.	Decorin
2.	Biomarkers (Surrogate Marker)
3.	Biglycan
4.	Aggrecans (Aggrecan)
5.	Lumican
6.	Elastin
7.	Hyaluronic Acid (Hyaluronan)
8.	Messenger RNA (mRNA)
9.	Cytokines
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Low-Level Light Therapy (LLLT)
4.	Cytoreduction Surgical Procedures
5.	Catheters