Progesterone

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Also Known As:

Networked: 8924 relevant articles (331 outcomes, 1038 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Stein, Donald G: 63 articles (10/2015 - 11/2002)
2.	Frye, Cheryl A: 34 articles (07/2014 - 01/2003)
3.	Sayeed, Iqbal: 25 articles (09/2015 - 04/2006)
4.	De Nicola, Alejandro F: 22 articles (11/2015 - 12/2002)
5.	Schumacher, Michael: 21 articles (11/2015 - 11/2002)
6.	Bulun, Serdar E: 21 articles (09/2015 - 05/2003)
7.	Guennoun, Rachida: 19 articles (11/2015 - 12/2002)
8.	Camacho-Arroyo, Ignacio: 17 articles (11/2015 - 12/2004)
9.	Labombarda, Florencia: 17 articles (11/2015 - 12/2002)
10.	Kim, J Julie: 17 articles (09/2015 - 02/2007)

Related Diseases

1.	Premature Birth (Birth, Premature) 03/01/2010 - "Progesterone treatment has proven to be effective in preventing recurrent preterm birth. " 01/01/2009 - "While there have been recent reports of progesterone supplementation for women at risk of preterm birth which show promise in this intervention, there is currently insufficient data on clinically important outcomes for both women and infants to enable informed clinical decision-making. " 01/01/2013 - "Progesterone versus placebo for women with 'other' risk factors for preterm birth Progesterone, was associated with a statistically significant reduction in the risk of infant birthweight less than 2500 g (three studies; 482 infants; RR 0.48, 95% CI 0.25 to 0.91). " 01/01/2011 - "Previous studies showed good results of progesterone in women with either a history of preterm birth or a short cervix. " 01/01/2009 - "Two new randomized controlled trials of women with previous preterm birth were added to the four analyzed in the Cochrane review, and the meta-analysis of all six studies now showed that progesterone supplementation was associated with a significant reduction of delivery before 32 weeks and of perinatal mortality. "
2.	Neoplasms (Cancer) 03/01/1980 - "Incorporation of a fluorescent progesterone conjugate into the histochemical reagent may help to confirm the existence of an operative receptor system in the cancer cells. " 01/01/1980 - "After a month's subsequent treatment with progesterone the tumor regressed and the patients' condition improved." 09/01/2015 - "Accurate and precise measures of progesterone metabolites are needed for etiologic studies of hormonally related cancers. " 01/01/2015 - "Future studies may concentrate on evaluating intracytoplasmic PIBF to possibly help determine which tumors may respond to progesterone antagonist receptors." 07/23/2014 - "In this study we report the cytotoxic effect on human cancer cells of two series of novel progesterone derivatives; the first containing an aromatic ester (8a-e) or a carbamate functions both linked to C-3 (9a-e) on the pregn-4,16-diene-6,20-dione skeleton. "
3.	Brain Injuries (Brain Injury) 08/15/2011 - "Progesterone has been found to be beneficial in several animal species, different models of brain injury, and in two preliminary human clinical trials. " 05/01/2011 - "Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. " 07/01/2009 - "Clinical trials have shown that short-and long-term progesterone treatment induces a significant improvement in the level of disability among patients with brain injury. " 11/01/2012 - "Progesterone (PG), a promising therapeutic for treating traumatic brain injury, has been difficult to formulate into a high-dose/low-volume form for emergency intravenous administration due to its hydrophobicity and crystallinity. " 12/01/2011 - "Is progesterone therapy beneficial for acute traumatic brain injury?"
4.	Breast Neoplasms (Breast Cancer) 05/18/2005 - "Elevated serum progesterone concentrations were associated with a statistically significant reduction in breast cancer risk (OR for highest versus lowest quartile = 0.61, 95% CI = 0.38 to 0.98; P(trend) = .06). " 01/01/2002 - "Because early parity provides significant protection against breast cancer whereas prolonged exposure to premenopausal ovarian progesterone (or to postmenopausal supplementations thereof) has been linked to breast cancer risk, this steroid can be considered to exhibit contrasting roles in breast cancer etiology. " 06/27/1997 - "Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation." 06/01/1996 - "Thus this study has confirmed that a raised level of progesterone at the time of tumour excision is associated with an improvement in prognosis for women with operable breast cancer." 07/01/2015 - "This study provides a new mechanistic basis for progesterone and radiation-induced breast cancer risk in basal cells. "
5.	Hemorrhage 05/01/2000 - "Women reported improved perceptions of their patterns of vaginal bleeding and control of menopausal symptoms while on the micronized progesterone-containing regimen. " 01/01/2014 - "In the present study, we evaluate the effect and possible mechanism of progesterone on SAH-induced vasospasm in a two-hemorrhage rodent model of SAH. " 07/01/2013 - "In addition to the known relationships, the present study identified a close relationship between maternal vaginal bleeding and progesterone therapy during early pregnancy and IH. " 12/01/2012 - "This study investigated the duration of the interval between the onset of vulval bleeding at pro-oestrus and ovulation estimated from the plasma progesterone concentration in a large number of beagle bitches. " 04/01/2007 - "In a prospective observational study, we compared the performance of three models for the prediction of pregnancy failure in women with a PUL: (i) logistic-regression model incorporating vaginal bleeding, endometrial thickness (ET), initial serum progesterone and hCG levels; (ii) serum progesterone at 0 h; and (3) the hCG ratio. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estradiol (Estrace)
3.	Hormones
4.	Progesterone Receptors (Progesterone Receptor)
5.	Progestins (Progestagens)
6.	Testosterone (Sustanon)
7.	estradiol 3-benzoate (estradiol benzoate)
8.	Mifepristone (RU 486)
9.	Suppositories (Vaginal Suppositories)
10.	Tamoxifen

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Injections
3.	Estrogen Replacement Therapy
4.	Cervical Cerclage
5.	Ovariectomy (Oophorectomy)