Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: Clinically achievable doses of GA blocked growth, colony formation and DNA synthesis of C6 glioma in vitro with high significance. GA enhanced the survival of EAC-bearing mice at a dosage of 0.4 mg/mice/day, in which 33% of the treated animals survived more than 3-weeks, when all untreated mice succumbed to their tumors. Selenium decreased EST volumes initially, yet increased tumor volumes at later stages in surviving mice. GA alone reduced solid tumor growth and did not modify selenite antineoplasticity initially, but blocked the late tumor-stimulating effects of selenite. Lastly, doxorubicin-induced cardiac myofibrillary and endothelial damage and hyalinization necrosis were attenuated with GA treatment. CONCLUSIONS: GA highly merits to be studied in further animal models as an anticancer and chemoprotective drug.
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Authors | Meric A Altinoz, Ilhan Elmaci, Salih Cengiz, Ebru Emekli-Alturfan, Aysel Ozpinar |
Journal | Chemico-biological interactions
(Chem Biol Interact)
Vol. 291
Pg. 29-39
(Aug 01 2018)
ISSN: 1872-7786 [Electronic] Ireland |
PMID | 29885857
(Publication Type: Journal Article)
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Copyright | Copyright © 2018. Published by Elsevier B.V. |
Chemical References |
- Cardiotonic Agents
- Gentisates
- Sodium Selenite
- Aspirin
- 2,5-dihydroxybenzoic acid
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Topics |
- Animals
- Aspirin
(pharmacology, therapeutic use)
- Brain Neoplasms
(drug therapy, epidemiology, prevention & control)
- Breast Neoplasms
(drug therapy, epidemiology, prevention & control)
- Carcinoma, Ehrlich Tumor
(drug therapy, pathology)
- Cardiotonic Agents
(pharmacology, therapeutic use)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Female
- Gentisates
(metabolism)
- Male
- Mice, Inbred BALB C
- Myocardium
(pathology, ultrastructure)
- S Phase
(drug effects)
- Sodium Selenite
(pharmacology, therapeutic use)
- Survival Analysis
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