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Arachidonate 12-Lipoxygenase (12 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Also Known As:
12 Lipoxygenase; Arachidonate 12 Lipoxygenase; Arachidonic Acid 12-Lipoxygenase; 12-Lipoxygenase, Arachidonate; 12-Lipoxygenase, Arachidonic Acid; Arachidonic Acid 12 Lipoxygenase; 12-Lipoxygenase; Arachidonate:oxygen 12-oxidoreductase
Networked: 269 relevant articles (4 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Honn, Kenneth V: 12 articles (01/2017 - 01/2002)
2. Nadler, Jerry L: 8 articles (01/2021 - 03/2002)
3. Honn, K V: 8 articles (07/2013 - 03/2000)
4. Jankun, Jerzy: 6 articles (01/2014 - 05/2006)
5. Nie, D: 6 articles (07/2013 - 03/2000)
6. Tang, Keqin: 5 articles (01/2017 - 01/2003)
7. Nie, Daotai: 5 articles (09/2014 - 01/2003)
8. Skrzypczak-Jankun, Ewa: 5 articles (01/2014 - 05/2006)
9. Mirmira, Raghavendra G: 4 articles (01/2021 - 10/2014)
10. Xu, Zhong-Gao: 4 articles (01/2019 - 04/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Leukemia
4. Myocardial Ischemia (Ischemic Heart Diseases)
5. Reperfusion Injury

Related Drugs and Biologics

1. Enzymes
2. Cyclooxygenase 2 (Cyclooxygenase-2)
3. Acids
4. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
5. Hydroxyeicosatetraenoic Acids (HETE)
6. NF-kappa B (NF-kB)
7. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
8. Arachidonate 12-Lipoxygenase (12 Lipoxygenase)
9. Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)
10. Lipoxygenases

Related Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Ligation
4. Lasers (Laser)