Serum Interleukin-10 Levels Correlate with Cerebrospinal Fluid Amyloid Beta Deposition in Alzheimer Disease Patients.

Abstract

BACKGROUND AND OBJECTIVE:

In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. However, the association between inflammation, cognitive impairment, and cerebrospinal biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio) is poorly understood.

METHODS:

A large panel of inflammatory cytokines (interleukin [IL]-1β, IL-1ra, IL-2, IL-4, IL-6, IL-10, IL-17, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor) was analyzed using a multiplex immunoassay in 27 patients with a diagnosis of AD dementia and in 18 control subjects. In a subgroup with available cerebrospinal fluid (CSF) samples, cytokines in serum were correlated with the levels of neurodegenerative CSF biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio).

RESULTS:

Compared to control subjects, AD patients showed a significant upregulation of IL-10, IL-1β, and IL-17 serum levels. Several cytokines appeared intercorrelated, and IL-10 in particular presented a significant inverse correlation with CFS levels of Aβ42 and the Aβ42/p-tau ratio.

CONCLUSION:

Our findings indicate that serum levels of IL-10 may represent a possible peripheral expression of amyloid beta deposition in AD patients.

• Authors: Lucio D'Anna, Samir Abu-Rumeileh, Martina Fabris, Cinzia Pistis, Antonio Baldi, Nova Sanvilli, Francesco Curcio, Gian Luigi Gigli, Sebastiano D'Anna, Mariarosaria Valente
• Journal: Neuro-degenerative diseases (Neurodegener Dis) Vol. 17 Issue 4-5 Pg. 227-234 ( 2017) ISSN: 1660-2862 [Electronic] Switzerland
• PMID: 28719891 (Publication Type: Journal Article)
• Copyright: © 2017 S. Karger AG, Basel.

Chemical References

• Amyloid beta-Peptides
• Cytokines
• Peptide Fragments
• Vascular Endothelial Growth Factor A
• amyloid beta-protein (1-42)
• tau Proteins

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (blood, cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Cytokines (blood)
• Female
• Humans
• Independent Living
• Male
• Middle Aged
• Peptide Fragments (cerebrospinal fluid)
• Retrospective Studies
• Statistics as Topic
• Vascular Endothelial Growth Factor A (blood)
• tau Proteins (cerebrospinal fluid)