Abstract | BACKGROUND:
Obesity and related complications have now became epidemic both in developed and developing countries. Cafeteria type diet mainly composed of high fat high carbohydrate components which plays a significant role in the development of obesity and metabolic syndrome. This study investigated the effect of Syzygium cumini seed powder on fat accumulation and dyslipidemia in high carbohydrate high fat diet (HCHF) induced obese rats. METHOD: Male Wistar rats were fed with HCHF diet ad libitum, and the rats on HCHF diet were supplemented with Syzygium cumini seed powder for 56 days (2.5% w/w of diet). Oral glucose tolerance test, lipid parameters, liver marker enzymes (AST, ALT and ALP) and lipid peroxidation products were analyzed at the end of 56 days. Moreover, antioxidant enzyme activities were also measured in all groups of rats. RESULTS: CONCLUSION: Our investigation suggests that Syzygium cumini seed powder supplementation prevents oxidative stress and showed anti-inflammatory and antifibrotic activity in liver of HCHF diet fed rats. In addition, Syzygium cumini seed powder may be beneficial in ameliorating insulin resistance and dyslipidemia probably by increasing lipid metabolism in liver of HCHF diet fed rats.
|
Authors | Anayt Ulla, Md Ashraful Alam, Biswajit Sikder, Farzana Akter Sumi, Md Mizanur Rahman, Zaki Farhad Habib, Mostafe Khalid Mohammed, Nusrat Subhan, Hemayet Hossain, Hasan Mahmud Reza |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 17
Issue 1
Pg. 289
(Jun 02 2017)
ISSN: 1472-6882 [Electronic] England |
PMID | 28578702
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Diet, High-Fat
(adverse effects)
- Dietary Carbohydrates
(adverse effects)
- Glucose Intolerance
(diet therapy, metabolism, prevention & control)
- Humans
- Hyperlipidemias
(diet therapy, metabolism, prevention & control)
- Male
- Obesity
(diet therapy, metabolism, prevention & control)
- Oxidative Stress
- Rats
- Rats, Wistar
- Seeds
(chemistry, metabolism)
- Syzygium
(chemistry, metabolism)
|