Abstract | AIM: MATERIALS AND METHODS: We compared isocaloric diets containing 30% of energy either as AP or PP, using newly developed PP-enriched foods, both combined with 30% energy as fat and 40% as carbohydrates in 44 patients with T2DM over 6 weeks in a randomized parallel-group study. Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamps and cardiovascular variables were measured. RESULTS:
Uric acid decreased in both groups, but significantly more in the AP than the PP group. There were no significant differences in other variables, although glycated haemoglobin levels, diastolic blood pressure and fasting non- esterified fatty acid levels improved significantly in the PP but not in the AP group. Insulin sensitivity (M-value), C-reactive protein and fasting glucose improved significantly in the AP but not in the PP group. Total and LDL cholesterol levels and systolic blood pressure decreased significantly in both groups, and the urinary albumin excretion rate decreased from baseline in participants with microalbuminuria. CONCLUSIONS: Isocaloric diets high in AP or PP allow similar improvements in metabolism and cardiovascular risk factors in people with T2DM, indicating that the differences in amino acid composition do not affect the metabolic responses to the interventions.
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Authors | Stephanie Sucher, Mariya Markova, Silke Hornemann, Olga Pivovarova, Natalia Rudovich, Ralph Thomann, Rosemarie Schneeweiss, Sascha Rohn, Andreas F H Pfeiffer |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 19
Issue 7
Pg. 944-952
(07 2017)
ISSN: 1463-1326 [Electronic] England |
PMID | 28181738
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | © 2017 John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Plant Proteins, Dietary
- Uric Acid
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Cardiovascular Diseases
(complications, epidemiology, prevention & control)
- Cohort Studies
- Dairy Products
(adverse effects)
- Diabetes Mellitus, Type 2
(blood, complications, diet therapy, metabolism)
- Diabetic Angiopathies
(epidemiology, prevention & control)
- Diabetic Cardiomyopathies
(epidemiology, prevention & control)
- Diet, Diabetic
(methods)
- Female
- Germany
(epidemiology)
- Humans
- Hypercholesterolemia
(complications, epidemiology, prevention & control)
- Hyperglycemia
(prevention & control)
- Insulin Resistance
- Male
- Meat
(adverse effects)
- Middle Aged
- Plant Proteins, Dietary
(administration & dosage, adverse effects)
- Risk Factors
- Uric Acid
(blood)
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