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LDL Cholesterol

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Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.

Also Known As:

Cholesterol, LDL; Cholesteryl Linoleate, LDL; LDL Cholesteryl Linoleate; Low Density Lipoprotein Cholesterol; beta-Lipoprotein Cholesterol; Cholesterol, beta-Lipoprotein; beta Lipoprotein Cholesterol

Networked: 9159 relevant articles (397 outcomes, 1163 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Kastelein, John J P: 67 articles (08/2015 - 04/2002)
2.	Ballantyne, Christie M: 60 articles (11/2015 - 03/2002)
3.	Ridker, Paul M: 38 articles (12/2015 - 01/2002)
4.	Rader, Daniel J: 31 articles (11/2015 - 11/2002)
5.	Watts, Gerald F: 28 articles (12/2015 - 02/2002)
6.	Stein, Evan A: 27 articles (11/2015 - 02/2002)
7.	Davidson, Michael H: 27 articles (06/2014 - 03/2003)
8.	Nicholls, Stephen J: 26 articles (10/2015 - 02/2007)
9.	Boerwinkle, Eric: 26 articles (02/2015 - 03/2002)
10.	Nordestgaard, Børge G: 25 articles (09/2015 - 01/2002)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/2011 - "Except for low-density lipoprotein cholesterol, all risk factors significantly improved with ≥ 20% loss of body weight. " 08/01/2000 - "In this small group of patients, there was a statistically significant reduction in low-density lipoprotein cholesterol (P = 0.04) and body weight (P = 0.001), as assessed by repeated measures analysis of variance. " 04/01/2003 - "Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL cholesterol beyond what could be expected given the weight lost." 12/01/2013 - "Studies have suggested that food rich in dietary fiber may facilitate body weight loss, lower total and LDL-cholesterol levels, and reduce body fat. " 06/01/2012 - "Rats fed an HCD exhibited a significant increase in LDL cholesterol levels (p<0.001) and body weight (p=0.017), when compared to the groups fed a ND during the ten-week study period. "
2.	Coronary Disease (Coronary Heart Disease) 01/01/2004 - "Statins are recommended as first-line treatment for lowering low-density lipoprotein cholesterol levels in women and are extremely valuable in reducing coronary heart disease risk in this group. " 01/01/2012 - "Deletion of PCSK9, and loss-of-function mutants in humans result in lower levels of circulating LDL-cholesterol and a strong protection against coronary heart disease. " 12/01/2008 - "Furthermore, PCSK9 deficiency leads to significantly lowered LDL cholesterol levels in humans and provides dramatic protection against coronary heart disease. " 12/01/2008 - "Strong epidemiologic and experimental data suggest that increasing dietary fiber may help to lower low-density lipoprotein cholesterol (LDL-C) and decrease the risk of coronary heart disease. " 10/01/2008 - "This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD). "
3.	Hypercholesterolemia 06/01/2012 - "Though this case series is limited by small sample size, study duration, and lack of control group, the product's significant reduction in LDL cholesterol without severe side effects indicates that this product may be a clinically effective and well tolerated alternative treatment to using statin medications to treat hypercholesterolemia." 11/15/2015 - "Vyto10, Vyto20, and Simva20 showed significant reduction of LDL cholesterol levels and improvement of flow-mediated dilation in patients with hypercholesterolemia. " 02/01/2015 - "The relative changes in total and LDL cholesterol were significantly greater for subjects with severe hypercholesterolemia (>6.6 mmol/L) than those with moderate hypercholesterolemia (5.2-6.6 mmol/L). " 06/01/2011 - "Baseline and follow-up evaluations showed improvement in hypercholesterolemia and high LDL cholesterol levels in cases versus controls. " 06/01/1992 - "The findings suggest that the significant reduction in serum LDL cholesterol levels in patients with CHD concurrent with hypercholesterolemia who take hypolipidemic therapy is followed by a decrease in the atherogenic potential."
4.	Cardiovascular Diseases (Cardiovascular Disease) 06/01/2013 - "Statins are the most widely used group of lipid-lowering drugs and they have been shown to be effective in the prevention of cardiovascular disease, primarily by reducing plasma low-density lipoprotein cholesterol concentrations and possibly through other pleiotropic effects. " 09/01/2011 - "Reduction of low-density lipoprotein cholesterol (LDL-C) with statins is highly effective in reducing cardiovascular disease in patients with and without diabetes, but leaves unaddressed a sizeable residual vascular risk (RvR), which is rarely quantified in routine clinical practice. " 01/24/2015 - "Homozygous familial hypercholesterolaemia is a rare, serious disorder caused by very low or absent plasma clearance of LDL, substantially raised LDL cholesterol, and accelerated development of cardiovascular disease. " 09/01/2015 - "Statins are reportedly effective in the primary and secondary prevention of cardiovascular disease, mainly due to their ability to aggressively reduce low-density lipoprotein cholesterol (LDL-C) levels. " 12/01/2014 - "It is well recognized that low-density lipoprotein cholesterol (LDL-C)-lowering therapy is effective for primary and secondary prevention of cerebrovascular/cardiovascular disease. "
5.	Atherosclerosis 01/01/2009 - "Statins, originally discovered in molds are the most effective medication to decrease the low-density cholesterol (LDL-C) which is the key participant in atherogenesis. " 05/01/2015 - "The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerosis is well recognized, and the use of LDL-C lowering medications has led to a significant reduction of cardiovascular risk in both primary and secondary prevention. " 04/01/2004 - "The significantly lower LDL cholesterol suggests that this polymorphism may confer protection against atherosclerosis in type 2 diabetes." 02/01/2007 - "Subjects bearing the -3608 C allele present a plasma lipid profile protective against atherogenesis: decrease of plasma LDL-cholesterol level (p=0.001) and of the LDL/HDL ratio (p=0.0003). " 01/01/2015 - "Epidemiological and clinical studies have clearly established the link between low-density lipoprotein cholesterol (LDL-C) and atherosclerosis-related cardiovascular consequences. "

Related Drugs and Biologics

1.	Cholesterol
2.	HDL Cholesterol
3.	Triglycerides (Triacylglycerol)
4.	Lipoproteins (Lipoprotein)
5.	Insulin (Novolin)
6.	Glucose (Dextrose)
7.	atorvastatin (Lipitor)
8.	Simvastatin (Zocor)
9.	rosuvastatin (Crestor)
10.	ezetimibe (Zetia)

Related Therapies and Procedures

1.	Blood Component Removal (Apheresis)
2.	Drug Therapy (Chemotherapy)
3.	Transplants (Transplant)
4.	Fat-Restricted Diet (Diet, Fat Restricted)
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)