Abstract | OBJECTIVES: MATERIALS AND METHODS: Adult male Wistar rats were divided into control and test groups (n=8). The test group was assigned into five subgroups; 4 groups, along with paclitaxel administration (7.5 mg/kg BW, weekly), received various doses of royal jelly (50, 100, and 150 mg/kg BW) for 28 consecutive days. The last group received only royal jelly at 100 mg/kg. In addition to oxidative and nitrosative stress biomarkers, the creatine kinase (CK-BM) level was also determined. To show the cardioprotective effect of royal jelly on paclitaxel-induced damages, histopathological examinations were conducted. RESULTS: CONCLUSION: Our data suggest that the paclitaxel-induced histopathological and biochemical alterations could be protected by the royal jelly administration. The cardioprotective effect of royal jelly may be related to the suppression of oxidative and nitrosative stress.
|
Authors | Hassan Malekinejad, Sima Ahsan, Fatemeh Delkhosh-Kasmaie, Hadi Cheraghi, Ali Rezaei-Golmisheh, Hamed Janbaz-Acyabar |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 19
Issue 2
Pg. 221-7
(Feb 2016)
ISSN: 2008-3866 [Print] Iran |
PMID | 27081469
(Publication Type: Journal Article)
|