Abstract | BACKGROUND:
Tumor necrosis factor alpha (TNFα) is increased in patients with headache, neuropathic pain, periodontal and temporomandibular disease. This study and others have utilized TNF receptor 1/2 ( TNFR1/2) knockout (KO) animals to investigate the effect of TNFα dysregulation in generation and maintenance of chronic neuropathic pain. The present study determined the impact of TNFα dysregulation in a trigeminal inflammatory compression ( TIC) nerve injury model comparing wild-type (WT) and TNFR1/2 KO mice. METHODS: Chromic gut suture was inserted adjacent to the infraorbital nerve to induce the TIC model mechanical hypersensitivity. Cytokine proteome profiles demonstrated serology, and morphology explored microglial activation in trigeminal nucleus 10weeks post. RESULTS: CONCLUSIONS: The results suggest the dysregulated serum cytokine proteome profile and bilateral spinal trigeminal nucleus microglial activation are contributory to the bilateral mechanical hypersensitization in this chronic trigeminal neuropathic pain model in the mice with TNFα dysregulation. Data support involvement of both neurogenic and humoral influences in chronic neuropathic pain.
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Authors | F Ma, L Zhang, H S Oz, M Mashni, K N Westlund |
Journal | Neuroscience
(Neuroscience)
Vol. 300
Pg. 493-507
(Aug 06 2015)
ISSN: 1873-7544 [Electronic] United States |
PMID | 26033565
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Proteome
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tnfrsf1a protein, mouse
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Cytokines
(metabolism)
- Disease Models, Animal
- Facial Pain
(drug therapy, pathology, physiopathology)
- Hot Temperature
- Hyperalgesia
(drug therapy, pathology, physiopathology)
- Male
- Mice, 129 Strain
- Mice, Transgenic
- Microglia
(drug effects, pathology, physiology)
- Proteome
(metabolism)
- Receptors, Tumor Necrosis Factor, Type I
(genetics, metabolism)
- Receptors, Tumor Necrosis Factor, Type II
(genetics, metabolism)
- Touch
- Trigeminal Nerve Injuries
(drug therapy, pathology, physiopathology)
- Tumor Necrosis Factor-alpha
(metabolism)
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