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Hyperalgesia

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An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.

Also Known As:

Allodynia; Allodynia, Mechanical; Allodynia, Tactile; Allodynia, Thermal; Hyperalgesia, Mechanical; Hyperalgesia, Primary; Hyperalgesia, Secondary; Hyperalgesic Sensations; Mechanical Allodynia; Mechanical Hyperalgesia; Tactile Allodynia; Thermal Allodynia; Allodynias; Allodynias, Mechanical; Allodynias, Tactile; Allodynias, Thermal; Hyperalgesias; Hyperalgesias, Mechanical; Hyperalgesias, Primary; Hyperalgesias, Secondary; Hyperalgesias, Tactile; Hyperalgesias, Thermal; Sensation, Hyperalgesic; Sensations, Hyperalgesic; Thermal Hyperalgesia; Hyperalgesia, Tactile; Hyperalgesia, Thermal

Networked: 8872 relevant articles (585 outcomes, 1371 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperalgesia
2.	Pain (Aches)
3.	Neuralgia (Stump Neuralgia)
4.	Inflammation
5.	Edema

Experts

1.	Levine, Jon D: 72 articles (09/2015 - 07/2002)
2.	Arendt-Nielsen, Lars: 49 articles (07/2015 - 01/2002)
3.	Porreca, Frank: 46 articles (01/2015 - 05/2002)
4.	Watkins, Linda R: 45 articles (05/2015 - 02/2003)
5.	Yaksh, Tony L: 43 articles (07/2015 - 01/2002)
6.	Ren, Ke: 41 articles (03/2013 - 02/2002)
7.	Maier, Steven F: 40 articles (05/2015 - 02/2003)
8.	Ji, Ru-Rong: 38 articles (11/2015 - 09/2002)
9.	Sluka, Kathleen A: 37 articles (01/2016 - 07/2002)
10.	Granados-Soto, Vinicio: 32 articles (06/2015 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperalgesia:

1.	Morphine (MS Contin)FDA LinkGeneric 12/31/1993 - "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/01/2004 - "A higher dose of morphine was required to produce mechanical allodynia in postnatal day 21 versus 7 rats but this increase was independent of the analgesic efficacy of morphine at these two ages. " 12/01/2006 - "However, compared with the control group, 1 mg/kg morphine was equally effective in reducing mechanical hyperalgesia among groups of animals gonadectomized as adults, but less effective in males gonadectomized neonatally. " 01/17/2003 - "Intrathecal morphine was also effective in alleviating the tactile allodynia induced by LPS. " 10/01/1989 - "On the other hand, when the dorsolateral funiculus was lesioned, the hyperalgesia was no longer observed, yet the antagonist remained effective against morphine. "
2.	CarrageenanIBA 01/22/2010 - "Our results show that a 3-week preoperative exposure to EE leads to a significant reduction in the duration of the carrageenan-induced mechanical allodynia, comparable with a post-operative exposure to EE. " 04/01/1994 - "into the right hindpaw, and exhibited hyperalgesia in the injected paw as evidenced by a significant reduction of withdrawal latencies from baseline 1, 3, 5, and 24 h following carrageenan. " 08/25/1992 - "A single unilateral injection of carrageenan (4.5-6.0 mg in 0.15-0.20 ml saline) into the rat hindpaw induced behavioral hyperalgesia as evidenced by a significant reduction in hindpaw withdrawal latency to a noxious thermal stimulus. " 05/01/1992 - "Anti-CGRP antibody produced an improvement in the hyperalgesia of RCS rats as well as carrageenan-induced hyperalgesia without having an effect on the nociceptive threshold of non-RCS rats. " 06/01/2014 - "Previous studies have shown that unilateral injection of carrageenan into the gastrocnemius muscle produces chronic thermal and mechanical hyperalgesia. "
3.	gabapentin (Neurontin)FDA LinkGeneric 04/01/2002 - "This study demonstrates that intrathecal gabapentin is effective against thermal and mechanical hyperalgesia, in spite of moderate impairment of motor coordination." 11/01/2015 - "Gabapentin was effective in transiently reversing mechanical allodynia in those mice with lowered thresholds. " 07/01/2012 - "Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia. " 01/01/2013 - "Treatment of mechanical allodynia with gabapentin improved altered dynamic gait parameters. " 12/01/2008 - "Gabapentin also improved mechanical allodynia in the same model, but efficacy disappeared the day after administration stopped. "
4.	Ketamine FDA LinkGeneric 06/01/2008 - "First, ketamine is highly effective against surgery and opiate-induced hyperalgesia. " 01/01/2006 - "A significant reduction of mechanical hyperalgesia was produced by topically and pre-emptively applied ketamine in healthy patients. " 05/09/1997 - "On the contralateral leg treated with ketamine, there was a significant reduction of primary hyperalgesia and an inhibition of development of secondary hyperalgesia. " 01/01/2011 - "Intrathecal ketamine relieved SNL-induced mechanical allodynia without interfering with motor performance. " 01/01/2011 - "Previous studies have demonstrated that low-dose ketamine can inhibit central sensitisation and prevent opioid-induced hyperalgesia (OIH). "
5.	Capsaicin (Zostrix)FDA Link 02/01/2001 - "Selective blockade of peripheral NK1 receptors in WT mice resulted in a complete inhibition of capsaicin-evoked plasma extravasation, but the mechanical hyperalgesia induced by 30 microg capsaicin intraplantar was still significantly greater than that seen in KO mice. " 01/01/2014 - "Our data suggest that intrathecal capsaicin could significantly attenuate thermal hyperalgesia, depending on the time when the drug is given after nerve injury, and that the antinociceptive efficacy of intrathecal capsaicin positively correlates with the previously reported dynamic profile of spinal transient receptor potential vanilloid 1 activity after nerve injury." 01/01/2011 - "To develop improved methods to assess single-sweeps, we applied a new approach in one healthy volunteer participating in a placebo controlled study of widespread hyperalgesia induced by perfusion of acid and capsaicin in the esophagus. " 11/01/2015 - "The aim of the present study was to characterize, using EEG, the effects of pinprick stimulation intensity on the magnitude of pinprick-elicited brain potentials [event-related potentials (ERPs)] before and after secondary hyperalgesia induced by intradermal capsaicin in humans. " 04/01/2015 - "In conclusion, this study for the first time demonstrates the time course of capsaicin-evoked heat hyperalgesia in and outside the site of application at the oral mucosa (primary and secondary hyperalgesia)."
6.	Lidocaine (Xylocaine)FDA LinkGeneric 06/01/2004 - "This work indicates that systemic rather than local administration of lidocaine would be more effective in treating tactile allodynia." 04/01/1999 - "Contralateral allodynia, despite its acute reversal during infusion to 2.1 microg/ml and higher, was not persistently relieved after infusion of lidocaine to any concentration. " 03/01/2009 - "Lidocaine may be particularly effective for thermal and mechanical allodynia. " 10/15/2008 - "Similar pretreatment with the effective concentration of lidocaine diminished injury-induced increases of the Ca v alpha2 delta1 in DRG and abolished that in spinal dorsal horn specifically, and resulted in a delayed onset of tactile allodynia post-injury. " 05/01/2003 - "Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions."
7.	Formaldehyde (Formol)FDA Link 01/01/2012 - "SA is effective in reducing formalin-induced mechanical allodynia and spinal neuronal hyperactivity. " 10/01/2011 - "These results establish the analgesic efficacy of intrathecal chromaffin cells on formalin-induced secondary allodynia. " 02/28/2015 - "The current study investigated the role of cannabinoid (CB1 and CB2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat. " 10/01/2013 - "The present study demonstrates that intramuscular formalin evokes biphasic muscle nociception, and that bilateral secondary mechanical hyperalgesia and heat hypoalgesia are differentially controlled by endogenous descending facilitation and inhibition respectively. " 04/01/2011 - "AEA induced a significant decrease in the nociceptive behavior during both phases of the formalin test in the animals treated with vehicle, while it abolished NTG-induced hyperalgesia during the phase II. Pre-treatment with AEA significantly reduced the NTG-induced neuronal activation in nucleus trigeminalis caudalis, confirming the results obtained in our previous study, and in area postrema, while the same treatment induced an increase of Fos expression in paraventricular and supraoptic nuclei of the hypothalamus, parabrachial nucleus, and periaqueductal grey. "
8.	salicylhydroxamic acid (SHAM)IBA 03/15/2013 - "Animals in the BPA group displayed significant mechanical hyperalgesia that continued through day 21 compared with animals in the sham-operated group, and mechanical hyperalgesia in the anti-p75NTR group was significantly improved 6 days after the operation. " 07/05/2011 - "The sham operation group had no decrease in postoperative paw withdrawal threshold, whereas the modified and traditional groups had significant reduction in paw withdrawal threshold after surgery (mechanical hyperalgesia). " 04/01/2015 - "Interictal allodynia, detected in 13 allodynic patients, improved after rTMS as compared with sham stimulation, and this effect appeared to be more evident in the late period. " 08/01/2015 - "Three days post-CCI, mechanical allodynia had developed in the ipsilateral paw compared with SHAM animals. " 04/20/2015 - "An intense acute swimming session of 1 or 2 h induced significant muscle mechanical hyperalgesia in a time-dependent manner in wild-type mice compared with the sham group 24 h after the session, which was further increased in IL-10(-/-) mice (P ˂ 0.05). "
9.	Streptozocin (Streptozotocin)FDA Link 03/06/2007 - "Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident from significant reduction in motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and increased thermal hyperalgesia. " 05/01/2011 - "Hence, the present study was designed as a 24-week longitudinal investigation of the extent to which the level of glycemic control in the streptozotocin (STZ)-diabetic rat model of Type 1 diabetes affects the development of mechanical allodynia and opioid hyposensitivity in these animals. " 03/01/2008 - "In the present study, using streptozotocin (STZ)-induced diabetic rats that displayed tactile allodynia, we found several morphological changes of activated microglia in the dorsal horn. " 11/01/2004 - "The present study was aimed at evaluating the role of PDE-5 inhibitor on nociception in streptozotocin-induced diabetes in animal models of nociception (writhing assay in mice and paw hyperalgesia test in rats). " 08/01/2003 - "Recent studies from our laboratory demonstrated that BKB1-R are implicated in streptozotocin (STZ)-diabetes-mediated hyperalgesia, since acute administration of the selective BKB1-R antagonists significantly and dose-dependently inhibited such hyperalgesic activity. "
10.	Opioid Analgesics (Opioids)IBA 10/01/2015 - "Nevertheless, cellular excitation has also been demonstrated, and proposed to mediate reduction of therapeutic efficacy and opioid-induced hyperalgesia upon prolonged exposure to opioids. " 12/20/1991 - "This suggests that the tonic inhibition exerted by the endogenous opioids was particularly effective in rats which recovered from their initial hyperalgesia. " 01/01/2010 - "However, the analgesic efficacy of opioids is compromised by side-effects such as analgesic tolerance, dependence and opioid-induced hyperalgesia (OIH). " 10/01/2015 - "There is conflicting evidence regarding the benefit of opioids in improving sleep quality, duration and efficiency with several studies and reviews suggesting a beneficial effect of opioids on sleep and other studies demonstrating the opioids can cause sleep disturbance leading to hyperalgesia. " 05/01/2015 - "The use of opioids may seem to be a double-edged sword; they provide straight analgesic and antihyperalgesic effects initially, but subsequently are associated with the expression of acute opioid tolerance (AOT) and opioid-induced hyperalgesia (OIH) that have been reported in experimental studies and clinical observations. "

Therapies and Procedures

1.	Ligation 03/01/1999 - "The most consistent behavioral finding (83%) was a marked decrease in monofilament-induced hindlimb withdrawal thresholds (mechanical allodynia) ipsilateral to the spinal nerve ligation. " 05/01/2002 - "Ligation of spinal nerves induced symptoms mimicking tactile allodynia, as indicated by a marked decrease of the hindlimb withdrawal threshold to mechanical stimulation. " 11/01/2003 - "At this time, both lesion groups displayed hyperalgesia to the cooling stimulus (P < 0.001), but the hyperalgesia in the ligation/cut group was significantly greater (P < 0.01). " 01/01/2011 - "At lower oral doses (0.3-1.0 mg/kg), AS1928370 improved mechanical allodynia in mice undergoing spinal nerve ligation. " 06/01/2011 - "In the present study, the effects of intrathecal and intracerebroventricular applications of 26RFa on the level of mechanical allodynia induced by partial sciatic nerve ligation were examined in rats. "
2.	Analgesia 06/01/2015 - "Together, these studies suggest that burst SCS does not act via spinal GABAergic mechanisms, despite its attenuation of spinal hyperexcitability and allodynia similar to that of tonic SCS; understanding other potential spinal inhibitory mechanisms may lead to enhanced analgesia during burst stimulation." 01/01/2015 - "This study investigated whether nocebo information provided during administration of an analgesic cream could reverse topical analgesia to hyperalgesia. " 02/01/2013 - "The present study examined the contribution of expectations to analgesia induced by heterotopic noxious counter-stimulation (HNCS) in healthy volunteers assigned to a control group or 1 of 3 experimental groups in which expectations were either assessed (a priori expectations) or manipulated using suggestions (hyperalgesia and analgesia). " 07/01/2011 - "Individuals who slept less than 6.5 h/night in the month prior to the study experienced significantly less behavioral analgesia, increased skin flare and augmented secondary hyperalgesia. " 01/01/2008 - "They have yielded contradictory results, showing hyperalgesia in some studies but analgesia in others. "
3.	Oral Administration 07/01/2015 - "The intensity of tactile allodynia in STZ-induced diabetic mice was alleviated by the oral administration of PGN; however, the antiallodynic effect varied according to its dosing time. " 01/01/2015 - "Intrathecal and oral administration of BE at different doses could alleviate the mechanical allodynia in CIBP rats. " 10/01/2014 - "Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. " 06/01/2014 - "Oral administration of Hp inhibits mechanical hyperalgesia of CCI-rats up to 6h. " 06/01/2014 - "Furthermore, Oral administration of CCR5 antagonist could reverse established tactile allodynia (8.20 ± 1.27 g vs. 3.18 ± 0.46 g; P < 0.05, n = 4 each). "
4.	Sympathectomy (Sympathectomies) 03/01/1995 - "Rats in which the sciatic nerve is partially transected develop hyperalgesia which is relieved by sympathectomy. " 01/16/1995 - "Hyperalgesia was also relieved by surgical sympathectomy, which eliminated the effects of NPY and its agonists. " 06/01/2011 - "Stress-induced hyperalgesia was abolished and the sensitization was attenuated by sympathectomy or systemic administration of an α-1-adrenergic antagonist. " 05/15/2008 - "Surgical sympathectomy reduced mechanical allodynia for 14 days after nerve root crush injury, and that DRG apoptosis was decreased in injured animals that underwent sympathectomy. " 05/15/2008 - "Sympathectomy prevented mechanical allodynia throughout the 14-day experimental period. "
5.	Injections 01/01/2001 - "Injections given 2 and 5 days apart produced a significantly greater mechanical hyperalgesia than injections given 10 days apart. " 03/01/2015 - "Intra-articular HA injections reduced the severity of OA, decreased mechanical hyperalgesia of the paw, but not weight-bearing asymmetry, and attenuated OA-associated up-regulation of CGRP, but not TrkA and ASIC3, in joint afferents. " 01/01/2012 - "Our previous studies demonstrated that ASICs are important in the development of hyperalgesia to repeated acid injections. " 01/01/2012 - "The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs reverses existing hyperalgesia. " 05/01/1996 - "The present study investigated the development of thermal and mechanical hyperalgesia following intracerebroventricular (i.c.v.) injections of E. "