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Minocycline (Cyclops)

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A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

Also Known As:

Cyclops; Arestin; Minocin; AHP Brand of Minocycline Hydrochloride; APS Brand of Minocycline Hydrochloride; Akamin; Akne-Puren; Aknemin; Aknin-Mino; Aknosan; Alphapharm Brand of Minocycline Hydrochloride; Alpharma Brand of Minocycline Hydrochloride; Apo-Minocycline; Apotex Brand of Minocycline Hydrochloride; Ashbourne Brand of Minocycline Hydrochloride; Bioglan Brand of Minocycline Hydrochloride; Blackwell Brand of Minocycline Hydrochloride; Blemix; Crookes Brand of Minocycline Hydrochloride; Cyclomin; Dentomycin; Dynacin; Expanscience Brand of Minocycline Hydrochloride; Faulding Brand of Minocycline Hydrochloride; Hermal Brand of Minocycline Hydrochloride; ICN Brand of Minocycline Hydrochloride; Icht-Oral; Ichthyol Brand of Minocycline Hydrochloride; Jenapharm Brand of Minocycline Hydrochloride; Klinomycin; Lederderm; Lederle Brand 1 of Minocycline Hydrochloride; Lederle Brand 2 of Minocycline Hydrochloride; Medicis Brand of Minocycline Hydrochloride; Merck Brand of Minocycline Hydrochloride; Mestacine; Minakne; Mino-Wolff; Minocin MR; Minoclir; Minocycline Hydrochloride; Minocycline Monohydrochloride; Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer; Minolis; Minomycin; Minoplus; Minotab; Minox 50; Mynocine; OraPharma Brand of Minocycline Hydrochloride; Rosen Brand of Minocycline Hydrochloride; Rowa Brand of Minocycline; Sanofi Synthelabo Brand of Minocycline Hydrochloride; Triax Pharmaceuticals Brand of Minocycline Hydrochloride; Wolff Brand of Minocycline Hydrochloride; Akne Puren; Aknin Mino; Apo Minocycline; Hydrochloride, Minocycline; Icht Oral; Mino Wolff; Monohydrochloride, Minocycline; 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-

Networked: 2358 relevant articles (338 outcomes, 410 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hess, David C: 18 articles (01/2014 - 04/2004)
2.	Fagan, Susan C: 17 articles (08/2015 - 04/2004)
3.	Mika, Joanna: 13 articles (02/2015 - 04/2007)
4.	Przewlocka, Barbara: 12 articles (02/2015 - 04/2007)
5.	Yong, V Wee: 11 articles (03/2015 - 06/2002)
6.	Jiang, Ying: 10 articles (05/2015 - 09/2010)
7.	Rojewska, Ewelina: 10 articles (02/2015 - 11/2009)
8.	Raad, Issam: 9 articles (01/2014 - 02/2002)
9.	Lessem, Jan: 9 articles (05/2008 - 07/2002)
10.	Makuch, Wioletta: 8 articles (02/2015 - 04/2007)

Related Diseases

1.	Infection 06/01/1992 - "We must take a look for Chlamydia trachomatis infection because this infection infrequently involves general organs, including the central nervous system and minocycline is very effective for this infection." 04/01/1977 - "Determination of efficacy of therapy in 23 of the patients who were evaluable showed that clinical and bacteriological results were satisfactory in 20 patients, unsatisfactory in 2, and questionable in 1. One patient developed a fatal secondary infection which may have been related to prior therapy with minocycline. " 09/01/2010 - "For effective treatment of infections with common equine pathogens, it will be necessary to administer minocycline at a dosage of 2.2 mg/kg, IV, every 12 hours. " 12/01/1994 - "The sequential combination therapy netilmycin and minocycline was seemed to be effective for MRSA infection." 06/01/1995 - "Minocycline possesses several attributes, making it potentially useful in the treatment of borrelial infections. "
2.	Acne Vulgaris 10/01/2006 - "For a long time, minocycline has been recognized as highly efficacious for the treatment of acne vulgaris but with use-limiting acute vestibular adverse events (AVAEs). " 01/01/1985 - "Once again Minocin treatment resulted in a highly significant improvement trend (p less than 0.0001) in the severity of acne. " 01/01/2012 - "Minocycline is an effective treatment for moderate to moderately-severe inflammatory acne vulgaris, but there is still no evidence that it is superior to other commonly-used therapies. " 01/01/2012 - "Although minocycline was shown to be an effective treatment for moderate to moderately-severe acne vulgaris, there was no evidence that it is better than any of the other commonly-used acne treatments. " 01/01/2010 - "Formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistant Propionibacterium acnes. "
3.	Rheumatoid Arthritis 05/01/2000 - "The third double-blind study enrolled only seropositive rheumatoid arthritis patients with early disease (less than 1 year duration), and showed very encouraging results of significant improvement in the disease activity parameters in the minocycline treated group of patients. " 05/01/2000 - "Summarising the data of these 3 double-blind studies, we may conclude that minocycline may be beneficial in patients with rheumatoid arthritis, especially when given early in the disease course or in patients with a mild disease." 08/01/1999 - "Although a number of clinical trials have shown minocycline to be effective in the treatment of rheumatoid arthritis, its use is limited and may become more limited with the recent introduction of new agents. " 10/01/1998 - "However, the antiinflammatory properties of minocycline have also made it useful in the management of various inflammatory conditions such as rheumatoid arthritis.1 We report the case of a 69-year-old woman who developed progressive cutaneous pigmentation, affecting mainly the legs, approximately 3 months after beginning minocycline therapy for rheumatoid arthritis." 07/01/1997 - "Two controlled studies found that minocycline benefited rheumatoid arthritis patients when it was given either as an adjunct to another second-line treatment or as the only slow-acting drug. "
4.	Inflammation 05/01/2011 - "Considering that inflammation may be a potential factor of POCD and minocycline is effective in improving cognitive dysfunction induced by inflammation, we hypothesize that minocycline may be useful to treat/prevent the POCD development after surgery in elderly patients." 04/01/2012 - "Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition." 02/01/2009 - "Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline." 01/01/2013 - "Modulating inflammation has been identified as a promising therapeutic avenue consistent with preliminary success of ongoing clinical trials for anti-inflammatory compounds such as minocycline. " 10/27/2010 - "Numerous studies have demonstrated that minocycline treatment attenuates allodynic and hyperalgesic behaviors induced by tissue inflammation or nerve injury. "
5.	Schizophrenia (Dementia Praecox) 01/01/2015 - "In addition, minocycline, an antibiotic and the best known inhibitor of microglial activation, has therapeutic efficacy in schizophrenia. " 01/01/2013 - " this study we aim to assess the efficacy of adjunctive minocycline to alleviate symptoms of schizophrenia in patients who have failed to respond to a therapeutic trial of antipsychotic medications. " 04/03/2014 - "On the other hand, there have been numerous reports that minocycline is effective in treating schizophrenia. " 04/01/2013 - "Furthermore, we reported that minocycline was effective in the animal models of schizophrenia. " 11/01/2009 - "Finally, minocycline add-on treatment appears to be effective on a broad range of psychopathology in patients with schizophrenia. "

Related Drugs and Biologics

1.	Tetracycline (Achromycin)
2.	Rifampin (Rifampicin)
3.	Doxycycline (Vibramycin)
4.	Tetracyclines
5.	Ofloxacin (Levofloxacin)
6.	Anti-Bacterial Agents (Antibiotics)
7.	Clarithromycin (Biaxin)
8.	Polymers
9.	Lymecycline
10.	tigecycline (Tygacil)

Related Therapies and Procedures

1.	Catheters
2.	Microspheres (Microsphere)
3.	Root Planing
4.	Aftercare (After-Treatment)
5.	Pleurodesis